94 related articles for article (PubMed ID: 21299225)
1. Dictyostatin flexibility bridges conformations in solution and in the β-tubulin taxane binding site.
Jogalekar AS; Damodaran K; Kriel FH; Jung WH; Alcaraz AA; Zhong S; Curran DP; Snyder JP
J Am Chem Soc; 2011 Mar; 133(8):2427-36. PubMed ID: 21299225
[TBL] [Abstract][Full Text] [Related]
2. The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin.
Canales A; Matesanz R; Gardner NM; Andreu JM; Paterson I; Díaz JF; Jiménez-Barbero J
Chemistry; 2008; 14(25):7557-69. PubMed ID: 18449868
[TBL] [Abstract][Full Text] [Related]
3. Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Field JJ; Pera B; Calvo E; Canales A; Zurwerra D; Trigili C; Rodríguez-Salarichs J; Matesanz R; Kanakkanthara A; Wakefield SJ; Singh AJ; Jiménez-Barbero J; Northcote P; Miller JH; López JA; Hamel E; Barasoain I; Altmann KH; Díaz JF
Chem Biol; 2012 Jun; 19(6):686-98. PubMed ID: 22726683
[TBL] [Abstract][Full Text] [Related]
4. NMR determination of the bioactive conformation of peloruside A bound to microtubules.
Jiménez-Barbero J; Canales A; Northcote PT; Buey RM; Andreu JM; Díaz JF
J Am Chem Soc; 2006 Jul; 128(27):8757-65. PubMed ID: 16819869
[TBL] [Abstract][Full Text] [Related]
5. A "methyl extension" strategy for polyketide natural product linker site validation and its application to dictyostatin.
Ho S; Sackett DL; Leighton JL
J Am Chem Soc; 2015 Nov; 137(44):14047-50. PubMed ID: 26522184
[TBL] [Abstract][Full Text] [Related]
6. Molecular mechanism of action of microtubule-stabilizing anticancer agents.
Prota AE; Bargsten K; Zurwerra D; Field JJ; Díaz JF; Altmann KH; Steinmetz MO
Science; 2013 Feb; 339(6119):587-90. PubMed ID: 23287720
[TBL] [Abstract][Full Text] [Related]
7. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Madiraju C; Edler MC; Hamel E; Raccor BS; Balachandran R; Zhu G; Giuliano KA; Vogt A; Shin Y; Fournier JH; Fukui Y; Brückner AM; Curran DP; Day BW
Biochemistry; 2005 Nov; 44(45):15053-63. PubMed ID: 16274252
[TBL] [Abstract][Full Text] [Related]
8. The discodermolide hairpin structure flows from conformationally stable modular motifs.
Jogalekar AS; Kriel FH; Shi Q; Cornett B; Cicero D; Snyder JP
J Med Chem; 2010 Jan; 53(1):155-65. PubMed ID: 19894728
[TBL] [Abstract][Full Text] [Related]
9. Solution conformations of amphidinolide H.
Shimbo K; Nozawa K; Tsuda M; Kobayashi J
Bioorg Med Chem; 2005 Sep; 13(17):5066-71. PubMed ID: 15869879
[TBL] [Abstract][Full Text] [Related]
10. Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.
Kellogg EH; Hejab NMA; Howes S; Northcote P; Miller JH; Díaz JF; Downing KH; Nogales E
J Mol Biol; 2017 Mar; 429(5):633-646. PubMed ID: 28104363
[TBL] [Abstract][Full Text] [Related]
11. Conformational preferences of natural and C3-modified epothilones in aqueous solution.
Erdélyi M; Pfeiffer B; Hauenstein K; Fohrer J; Gertsch J; Altmann KH; Carlomagno T
J Med Chem; 2008 Mar; 51(5):1469-73. PubMed ID: 18271516
[TBL] [Abstract][Full Text] [Related]
12. Cyclostreptin and microtubules: is a low-affinity binding site required?
Prussia AJ; Yang Y; Geballe MT; Snyder JP
Chembiochem; 2010 Jan; 11(1):101-9. PubMed ID: 19946930
[TBL] [Abstract][Full Text] [Related]
13. Structural basis of microtubule stabilization by laulimalide and peloruside A.
Prota AE; Bargsten K; Northcote PT; Marsh M; Altmann KH; Miller JH; Díaz JF; Steinmetz MO
Angew Chem Int Ed Engl; 2014 Feb; 53(6):1621-5. PubMed ID: 24470331
[TBL] [Abstract][Full Text] [Related]
14. Structure-based identification of the binding site for the hemiasterlin analogue HTI-286 on tubulin.
Ravi M; Zask A; Rush TS
Biochemistry; 2005 Dec; 44(48):15871-9. PubMed ID: 16313189
[TBL] [Abstract][Full Text] [Related]
15. Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
Canales A; Rodríguez-Salarichs J; Trigili C; Nieto L; Coderch C; Andreu JM; Paterson I; Jiménez-Barbero J; Díaz JF
ACS Chem Biol; 2011 Aug; 6(8):789-99. PubMed ID: 21539341
[TBL] [Abstract][Full Text] [Related]
16. Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol.
Thepchatri P; Eliseo T; Cicero DO; Myles D; Snyder JP
J Am Chem Soc; 2007 Mar; 129(11):3127-34. PubMed ID: 17323946
[TBL] [Abstract][Full Text] [Related]
17. A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Coderch C; Tang Y; Klett J; Zhang SE; Ma YT; Shaorong W; Matesanz R; Pera B; Canales A; Jiménez-Barbero J; Morreale A; Díaz JF; Fang WS; Gago F
Org Biomol Chem; 2013 May; 11(18):3046-56. PubMed ID: 23532250
[TBL] [Abstract][Full Text] [Related]
18. Relationship between the structures of taxane derivatives and their microtubule polymerization activity.
Hidaka M; Koga T; Kiyota H; Horiguchi T; Shi QW; Hirose K; Uchida T
Biosci Biotechnol Biochem; 2012; 76(2):349-52. PubMed ID: 22313785
[TBL] [Abstract][Full Text] [Related]
19. The solution structure of (+)-spongistatin 1 in DMSO.
Atasoylu O; Furst G; Risatti C; Smith AB
Org Lett; 2010 Apr; 12(8):1788-91. PubMed ID: 20297809
[TBL] [Abstract][Full Text] [Related]
20. Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.
Jung WH; Harrison C; Shin Y; Fournier JH; Balachandran R; Raccor BS; Sikorski RP; Vogt A; Curran DP; Day BW
J Med Chem; 2007 Jun; 50(13):2951-66. PubMed ID: 17542572
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
