These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

363 related articles for article (PubMed ID: 21303903)

  • 1. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
    Volkmann K; Lucas JL; Vuga D; Wang X; Brumm D; Stiles C; Kriebel D; Der-Sarkissian A; Krishnan K; Schweitzer C; Liu Z; Malyankar UM; Chiovitti D; Canny M; Durocher D; Sicheri F; Patterson JB
    J Biol Chem; 2011 Apr; 286(14):12743-55. PubMed ID: 21303903
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.
    Ali MM; Bagratuni T; Davenport EL; Nowak PR; Silva-Santisteban MC; Hardcastle A; McAndrews C; Rowlands MG; Morgan GJ; Aherne W; Collins I; Davies FE; Pearl LH
    EMBO J; 2011 Mar; 30(5):894-905. PubMed ID: 21317875
    [TBL] [Abstract][Full Text] [Related]  

  • 3. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.
    Thorpe JA; Schwarze SR
    Cell Stress Chaperones; 2010 Sep; 15(5):497-508. PubMed ID: 20013084
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.
    Chien W; Ding LW; Sun QY; Torres-Fernandez LA; Tan SZ; Xiao J; Lim SL; Garg M; Lee KL; Kitajima S; Takao S; Leong WZ; Sun H; Tokatly I; Poellinger L; Gery S; Koeffler PH
    Oncotarget; 2014 Jul; 5(13):4881-94. PubMed ID: 24952679
    [TBL] [Abstract][Full Text] [Related]  

  • 5. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
    Calfon M; Zeng H; Urano F; Till JH; Hubbard SR; Harding HP; Clark SG; Ron D
    Nature; 2002 Jan; 415(6867):92-6. PubMed ID: 11780124
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.
    Eletto D; Eletto D; Boyle S; Argon Y
    FASEB J; 2016 Feb; 30(2):653-65. PubMed ID: 26487694
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
    Cross BC; Bond PJ; Sadowski PG; Jha BK; Zak J; Goodman JM; Silverman RH; Neubert TA; Baxendale IR; Ron D; Harding HP
    Proc Natl Acad Sci U S A; 2012 Apr; 109(15):E869-78. PubMed ID: 22315414
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
    Concha NO; Smallwood A; Bonnette W; Totoritis R; Zhang G; Federowicz K; Yang J; Qi H; Chen S; Campobasso N; Choudhry AE; Shuster LE; Evans KA; Ralph J; Sweitzer S; Heerding DA; Buser CA; Su DS; DeYoung MP
    Mol Pharmacol; 2015 Dec; 88(6):1011-23. PubMed ID: 26438213
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
    Sanches M; Duffy NM; Talukdar M; Thevakumaran N; Chiovitti D; Canny MD; Lee K; Kurinov I; Uehling D; Al-awar R; Poda G; Prakesch M; Wilson B; Tam V; Schweitzer C; Toro A; Lucas JL; Vuga D; Lehmann L; Durocher D; Zeng Q; Patterson JB; Sicheri F
    Nat Commun; 2014 Aug; 5():4202. PubMed ID: 25164867
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production.
    Kim S; Joe Y; Kim HJ; Kim YS; Jeong SO; Pae HO; Ryter SW; Surh YJ; Chung HT
    J Immunol; 2015 May; 194(9):4498-506. PubMed ID: 25821218
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
    Mimura N; Fulciniti M; Gorgun G; Tai YT; Cirstea D; Santo L; Hu Y; Fabre C; Minami J; Ohguchi H; Kiziltepe T; Ikeda H; Kawano Y; French M; Blumenthal M; Tam V; Kertesz NL; Malyankar UM; Hokenson M; Pham T; Zeng Q; Patterson JB; Richardson PG; Munshi NC; Anderson KC
    Blood; 2012 Jun; 119(24):5772-81. PubMed ID: 22538852
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphoregulation of Ire1 RNase splicing activity.
    Prischi F; Nowak PR; Carrara M; Ali MM
    Nat Commun; 2014 Apr; 5():3554. PubMed ID: 24704861
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
    Tang CH; Ranatunga S; Kriss CL; Cubitt CL; Tao J; Pinilla-Ibarz JA; Del Valle JR; Hu CC
    J Clin Invest; 2014 Jun; 124(6):2585-98. PubMed ID: 24812669
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.
    Benhamron S; Hadar R; Iwawaky T; So JS; Lee AH; Tirosh B
    Eur J Immunol; 2014 Mar; 44(3):867-76. PubMed ID: 24242955
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.
    Lee AH; Iwakoshi NN; Anderson KC; Glimcher LH
    Proc Natl Acad Sci U S A; 2003 Aug; 100(17):9946-51. PubMed ID: 12902539
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Principles of IRE1 modulation using chemical tools.
    Lee KP; Sicheri F
    Methods Enzymol; 2011; 490():271-94. PubMed ID: 21266256
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.
    Zheng Y; Gao B; Ye L; Kong L; Jing W; Yang X; Wu Z; Ye L
    J Microbiol; 2005 Dec; 43(6):529-36. PubMed ID: 16410770
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The molecular mechanism and functional diversity of UPR signaling sensor IRE1.
    Bashir S; Banday M; Qadri O; Bashir A; Hilal N; Nida-I-Fatima ; Rader S; Fazili KM
    Life Sci; 2021 Jan; 265():118740. PubMed ID: 33188833
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.
    Back SH; Lee K; Vink E; Kaufman RJ
    J Biol Chem; 2006 Jul; 281(27):18691-706. PubMed ID: 16644724
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
    Newbatt Y; Hardcastle A; McAndrew PC; Strover JA; Mirza A; Morgan GJ; Burke R; Davies FE; Collins I; van Montfort RL
    J Biomol Screen; 2013 Mar; 18(3):298-308. PubMed ID: 23139381
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.