These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 21315150)

  • 1. Heterotetrameric forms of human phenylalanine hydroxylase: co-expression of wild-type and mutant forms in a bicistronic system.
    Leandro J; Leandro P; Flatmark T
    Biochim Biophys Acta; 2011 May; 1812(5):602-12. PubMed ID: 21315150
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperative substrate binding.
    Bjørgo E; de Carvalho RM; Flatmark T
    Eur J Biochem; 2001 Feb; 268(4):997-1005. PubMed ID: 11179966
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Co-expression of phenylalanine hydroxylase variants and effects of interallelic complementation on in vitro enzyme activity and genotype-phenotype correlation.
    Shen N; Heintz C; Thiel C; Okun JG; Hoffmann GF; Blau N
    Mol Genet Metab; 2016 Mar; 117(3):328-35. PubMed ID: 26803807
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.
    Knappskog PM; Flatmark T; Aarden JM; Haavik J; Martínez A
    Eur J Biochem; 1996 Dec; 242(3):813-21. PubMed ID: 9022714
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Co-expression of different subunits of human phenylalanine hydroxylase: evidence of negative interallelic complementation.
    Leandro J; Nascimento C; de Almeida IT; Leandro P
    Biochim Biophys Acta; 2006 May; 1762(5):544-50. PubMed ID: 16545551
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.
    Bjørgo E; Knappskog PM; Martinez A; Stevens RC; Flatmark T
    Eur J Biochem; 1998 Oct; 257(1):1-10. PubMed ID: 9799096
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The V388M mutation results in a kinetic variant form of phenylalanine hydroxylase.
    Leandro P; Rivera I; Lechner MC; de Almeida IT; Konecki D
    Mol Genet Metab; 2000 Mar; 69(3):204-12. PubMed ID: 10767175
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme.
    Martinez A; Knappskog PM; Olafsdottir S; Døskeland AP; Eiken HG; Svebak RM; Bozzini M; Apold J; Flatmark T
    Biochem J; 1995 Mar; 306 ( Pt 2)(Pt 2):589-97. PubMed ID: 7887915
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates.
    Boonyapiwat B; Mitchell SC; Steventon GB
    J Pharm Pharmacol; 2011 Apr; 63(4):558-64. PubMed ID: 21401608
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms.
    Carvalho RN; Solstad T; Bjørgo E; Barroso JF; Flatmark T
    J Biol Chem; 2003 Apr; 278(17):15142-52. PubMed ID: 12554741
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation.
    Stokka AJ; Flatmark T
    Biochem J; 2003 Feb; 369(Pt 3):509-18. PubMed ID: 12379147
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation.
    Leandro J; Simonsen N; Saraste J; Leandro P; Flatmark T
    Biochim Biophys Acta; 2011 Jan; 1812(1):106-20. PubMed ID: 20937381
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of mutations at Cys237 on the activation state and activity of human phenylalanine hydroxylase.
    Knappskog PM; Martínez A
    FEBS Lett; 1997 Jun; 409(1):7-11. PubMed ID: 9199493
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase.
    Hagedoorn PL; Schmidt PP; Andersson KK; Hagen WR; Flatmark T; Martínez A
    J Biol Chem; 2001 Jun; 276(25):22850-6. PubMed ID: 11301319
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability.
    Tomé CS; Lopes RR; Sousa PMF; Amaro MP; Leandro J; Mertens HDT; Leandro P; Vicente JB
    Sci Rep; 2019 Sep; 9(1):13615. PubMed ID: 31541188
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy.
    Chehin R; Thorolfsson M; Knappskog PM; Martinez A; Flatmark T; Arrondo JL; Muga A
    FEBS Lett; 1998 Jan; 422(2):225-30. PubMed ID: 9490012
    [TBL] [Abstract][Full Text] [Related]  

  • 17. L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.
    Thórólfsson M; Ibarra-Molero B; Fojan P; Petersen SB; Sanchez-Ruiz JM; Martínez A
    Biochemistry; 2002 Jun; 41(24):7573-85. PubMed ID: 12056888
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia.
    Waters PJ; Scriver CR; Parniak MA
    Mol Genet Metab; 2001 Jul; 73(3):230-8. PubMed ID: 11461190
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.
    Thórólfsson M; Teigen K; Martínez A
    Biochemistry; 2003 Apr; 42(12):3419-28. PubMed ID: 12653545
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conjugation of phenylalanine hydroxylase with polyubiquitin chains catalysed by rat liver enzymes.
    Døskeland AP; Flatmark T
    Biochim Biophys Acta; 2001 Jun; 1547(2):379-86. PubMed ID: 11410294
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.