BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

335 related articles for article (PubMed ID: 21326864)

  • 1. Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling.
    Wichard JD; Ter Laak A; Krause G; Heinrich N; Kühne R; Kleinau G
    PLoS One; 2011 Feb; 6(2):e16811. PubMed ID: 21326864
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.
    Kristiansen K
    Pharmacol Ther; 2004 Jul; 103(1):21-80. PubMed ID: 15251227
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models.
    Sgourakis NG; Bagos PG; Papasaikas PK; Hamodrakas SJ
    BMC Bioinformatics; 2005 Apr; 6():104. PubMed ID: 15847681
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7.
    Liu K; Jaggupilli A; Premnath D; Chelikani P
    Biochim Biophys Acta Biomembr; 2018 May; 1860(5):991-999. PubMed ID: 29355483
    [TBL] [Abstract][Full Text] [Related]  

  • 5. G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
    Kratochwil NA; Gatti-McArthur S; Hoener MC; Lindemann L; Christ AD; Green LG; Guba W; Martin RE; Malherbe P; Porter RH; Slack JP; Winnig M; Dehmlow H; Grether U; Hertel C; Narquizian R; Panousis CG; Kolczewski S; Steward L
    Curr Top Med Chem; 2011; 11(15):1902-24. PubMed ID: 21470172
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.
    Di Pizio A; Levit A; Slutzki M; Behrens M; Karaman R; Niv MY
    Methods Cell Biol; 2016; 132():401-27. PubMed ID: 26928553
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.
    Kooistra AJ; Kuhne S; de Esch IJ; Leurs R; de Graaf C
    Br J Pharmacol; 2013 Sep; 170(1):101-26. PubMed ID: 23713847
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Common activation mechanism of class A GPCRs.
    Zhou Q; Yang D; Wu M; Guo Y; Guo W; Zhong L; Cai X; Dai A; Jang W; Shakhnovich EI; Liu ZJ; Stevens RC; Lambert NA; Babu MM; Wang MW; Zhao S
    Elife; 2019 Dec; 8():. PubMed ID: 31855179
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family.
    Woolley MJ; Conner AC
    Mol Cell Endocrinol; 2017 Jul; 449():3-11. PubMed ID: 27899324
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression.
    Hawtin SR; Simms J; Conner M; Lawson Z; Parslow RA; Trim J; Sheppard A; Wheatley M
    J Biol Chem; 2006 Dec; 281(50):38478-88. PubMed ID: 16990262
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Emerging opportunities for allosteric modulation of G-protein coupled receptors.
    Wang CI; Lewis RJ
    Biochem Pharmacol; 2013 Jan; 85(2):153-62. PubMed ID: 22975406
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 7TM Domain Structure of Adhesion GPCRs.
    de Graaf C; Nijmeijer S; Wolf S; Ernst OP
    Handb Exp Pharmacol; 2016; 234():43-66. PubMed ID: 27832483
    [TBL] [Abstract][Full Text] [Related]  

  • 13. GPCRdb in 2018: adding GPCR structure models and ligands.
    Pándy-Szekeres G; Munk C; Tsonkov TM; Mordalski S; Harpsøe K; Hauser AS; Bojarski AJ; Gloriam DE
    Nucleic Acids Res; 2018 Jan; 46(D1):D440-D446. PubMed ID: 29155946
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.
    Worth CL; Kleinau G; Krause G
    PLoS One; 2009 Sep; 4(9):e7011. PubMed ID: 19756152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.
    Bhattacharya S; Hall SE; Vaidehi N
    J Mol Biol; 2008 Oct; 382(2):539-55. PubMed ID: 18638482
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors.
    Surgand JS; Rodrigo J; Kellenberger E; Rognan D
    Proteins; 2006 Feb; 62(2):509-38. PubMed ID: 16294340
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors.
    Wheatley M; Simms J; Hawtin SR; Wesley VJ; Wootten D; Conner M; Lawson Z; Conner AC; Baker A; Cashmore Y; Kendrick R; Parslow RA
    Biochem Soc Trans; 2007 Aug; 35(Pt 4):717-20. PubMed ID: 17635132
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.
    Fatakia SN; Costanzi S; Chow CC
    PLoS One; 2009; 4(3):e4681. PubMed ID: 19262747
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis of Smoothened regulation by its extracellular domains.
    Byrne EFX; Sircar R; Miller PS; Hedger G; Luchetti G; Nachtergaele S; Tully MD; Mydock-McGrane L; Covey DF; Rambo RP; Sansom MSP; Newstead S; Rohatgi R; Siebold C
    Nature; 2016 Jul; 535(7613):517-522. PubMed ID: 27437577
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.
    Coudrat T; Simms J; Christopoulos A; Wootten D; Sexton PM
    PLoS Comput Biol; 2017 Nov; 13(11):e1005819. PubMed ID: 29131821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.