110 related articles for article (PubMed ID: 21334796)
1. Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β.
Avila CM; Lopes AB; Gonçalves AS; da Silva LL; Romeiro NC; Miranda AL; Sant'Anna CM; Barreiro EJ; Fraga CA
Eur J Med Chem; 2011 Apr; 46(4):1245-53. PubMed ID: 21334796
[TBL] [Abstract][Full Text] [Related]
2. LASSBio-1829 Hydrochloride: Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties.
Guedes IA; Freitas RH; Cordeiro NM; do Nascimento TS; Valerio TS; Fernandes PD; Dardenne LE; Fraga CA
ChemMedChem; 2016 Jan; 11(2):234-44. PubMed ID: 26306006
[TBL] [Abstract][Full Text] [Related]
3. Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).
Christopher JA; Bamborough P; Alder C; Campbell A; Cutler GJ; Down K; Hamadi AM; Jolly AM; Kerns JK; Lucas FS; Mellor GW; Miller DD; Morse MA; Pancholi KD; Rumsey W; Solanke YE; Williamson R
J Med Chem; 2009 May; 52(9):3098-102. PubMed ID: 19348415
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
da Silva YK; Augusto CV; de Castro Barbosa ML; de Albuquerque Melo GM; de Queiroz AC; de Lima Matos Freire Dias T; Júnior WB; Barreiro EJ; Lima LM; Alexandre-Moreira MS
Bioorg Med Chem; 2010 Jul; 18(14):5007-15. PubMed ID: 20598893
[TBL] [Abstract][Full Text] [Related]
5. The small-molecule inhibitor selectivity between IKKα and IKKβ kinases in NF-κB signaling pathway.
Tian F; Zhou P; Kang W; Luo L; Fan X; Yan J; Liang H
J Recept Signal Transduct Res; 2015; 35(4):307-18. PubMed ID: 25386663
[TBL] [Abstract][Full Text] [Related]
6. Structure and dynamics of the kinase IKK-β--A key regulator of the NF-kappa B transcription factor.
Kalia M; Kukol A
J Struct Biol; 2011 Nov; 176(2):133-42. PubMed ID: 21820058
[TBL] [Abstract][Full Text] [Related]
7. Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
Catley MC; Sukkar MB; Chung KF; Jaffee B; Liao SM; Coyle AJ; Haddad el-B; Barnes PJ; Newton R
Mol Pharmacol; 2006 Aug; 70(2):697-705. PubMed ID: 16687566
[TBL] [Abstract][Full Text] [Related]
8. Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives.
Hernández P; Cabrera M; Lavaggi ML; Celano L; Tiscornia I; Rodrigues da Costa T; Thomson L; Bollati-Fogolín M; Miranda AL; Lima LM; Barreiro EJ; González M; Cerecetto H
Bioorg Med Chem; 2012 Mar; 20(6):2158-71. PubMed ID: 22356737
[TBL] [Abstract][Full Text] [Related]
9. Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.
Tributino JL; Duarte CD; Corrêa RS; Doriguetto AC; Ellena J; Romeiro NC; Castro NG; Miranda AL; Barreiro EJ; Fraga CA
Bioorg Med Chem; 2009 Feb; 17(3):1125-31. PubMed ID: 19135376
[TBL] [Abstract][Full Text] [Related]
10. The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Wu JP; Fleck R; Brickwood J; Capolino A; Catron K; Chen Z; Cywin C; Emeigh J; Foerst M; Ginn J; Hrapchak M; Hickey E; Hao MH; Kashem M; Li J; Liu W; Morwick T; Nelson R; Marshall D; Martin L; Nemoto P; Potocki I; Liuzzi M; Peet GW; Scouten E; Stefany D; Turner M; Weldon S; Zimmitti C; Spero D; Kelly TA
Bioorg Med Chem Lett; 2009 Oct; 19(19):5547-51. PubMed ID: 19716697
[TBL] [Abstract][Full Text] [Related]
11. Combination of pharmacophore model development and binding mode analyses: identification of ligand features essential for IκB kinase-beta (IKKβ) inhibitors and virtual screening based on it.
Sun HP; Zhu J; Chen FH; Zhang SL; Zhang Y; You QD
Eur J Med Chem; 2011 Sep; 46(9):3942-52. PubMed ID: 21708416
[TBL] [Abstract][Full Text] [Related]
12. IKK-beta inhibitors: an analysis of drug-receptor interaction by using molecular docking and pharmacophore 3D-QSAR approaches.
Lauria A; Ippolito M; Fazzari M; Tutone M; Di Blasi F; Mingoia F; Almerico AM
J Mol Graph Model; 2010 Aug; 29(1):72-81. PubMed ID: 20537930
[TBL] [Abstract][Full Text] [Related]
13. IKKbeta inhibitors identification part II: ligand and structure-based virtual screening.
Nagarajan S; Choo H; Cho YS; Oh KS; Lee BH; Shin KJ; Pae AN
Bioorg Med Chem; 2010 Jun; 18(11):3951-60. PubMed ID: 20488717
[TBL] [Abstract][Full Text] [Related]
14. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Hideshima T; Neri P; Tassone P; Yasui H; Ishitsuka K; Raje N; Chauhan D; Podar K; Mitsiades C; Dang L; Munshi N; Richardson P; Schenkein D; Anderson KC
Clin Cancer Res; 2006 Oct; 12(19):5887-94. PubMed ID: 17020997
[TBL] [Abstract][Full Text] [Related]
15. Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties.
Cordeiro NM; Freitas RH; Fraga CA; Fernandes PD
PLoS One; 2016; 11(5):e0156271. PubMed ID: 27227468
[TBL] [Abstract][Full Text] [Related]
16. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes.
Lacerda RB; de Lima CK; da Silva LL; Romeiro NC; Miranda AL; Barreiro EJ; Fraga CA
Bioorg Med Chem; 2009 Jan; 17(1):74-84. PubMed ID: 19059783
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of IKK-beta: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32.
Bhattarai BR; Ko JH; Shrestha S; Kafle B; Cho H; Kang JH; Cho H
Bioorg Med Chem Lett; 2010 Feb; 20(3):1075-7. PubMed ID: 20044255
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: an analogue-based drug design approach.
Sharma RN; Xavier FP; Vasu KK; Chaturvedi SC; Pancholi SS
J Enzyme Inhib Med Chem; 2009 Jun; 24(3):890-7. PubMed ID: 19469712
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and biological evaluation of novel
Xie X; Tu J; You H; Hu B
Drug Des Devel Ther; 2017; 11():1439-1451. PubMed ID: 28553074
[TBL] [Abstract][Full Text] [Related]
20. Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.
Horiuchi T; Nagata M; Kitagawa M; Akahane K; Uoto K
Bioorg Med Chem; 2009 Dec; 17(23):7850-60. PubMed ID: 19889545
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
