142 related articles for article (PubMed ID: 21334890)
1. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors.
Majmudar JD; Hahne K; Hrycyna CA; Gibbs RA
Bioorg Med Chem Lett; 2011 May; 21(9):2616-20. PubMed ID: 21334890
[TBL] [Abstract][Full Text] [Related]
2. Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.
Bergman JA; Hahne K; Hrycyna CA; Gibbs RA
Bioorg Med Chem Lett; 2011 Sep; 21(18):5616-9. PubMed ID: 21782433
[TBL] [Abstract][Full Text] [Related]
3. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.
Majmudar JD; Hodges-Loaiza HB; Hahne K; Donelson JL; Song J; Shrestha L; Harrison ML; Hrycyna CA; Gibbs RA
Bioorg Med Chem; 2012 Jan; 20(1):283-95. PubMed ID: 22142613
[TBL] [Abstract][Full Text] [Related]
4. Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes.
Hahne K; Vervacke JS; Shrestha L; Donelson JL; Gibbs RA; Distefano MD; Hrycyna CA
Biochem Biophys Res Commun; 2012 Jun; 423(1):98-103. PubMed ID: 22634004
[TBL] [Abstract][Full Text] [Related]
5. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.
Donelson JL; Hodges HB; Macdougall DD; Henriksen BS; Hrycyna CA; Gibbs RA
Bioorg Med Chem Lett; 2006 Aug; 16(16):4420-3. PubMed ID: 16777414
[TBL] [Abstract][Full Text] [Related]
6. Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites.
Diver MM; Long SB
J Biol Chem; 2014 Sep; 289(38):26007-26020. PubMed ID: 25059662
[TBL] [Abstract][Full Text] [Related]
7. The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors.
Anderson JL; Henriksen BS; Gibbs RA; Hrycyna CA
J Biol Chem; 2005 Aug; 280(33):29454-61. PubMed ID: 15946942
[TBL] [Abstract][Full Text] [Related]
8. Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.
Butler KV; Bohn K; Hrycyna CA; Jin J
Medchemcomm; 2016 May; 7(5):1016-1021. PubMed ID: 27547295
[TBL] [Abstract][Full Text] [Related]
9. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).
Ramanujulu PM; Yang T; Yap SQ; Wong FC; Casey PJ; Wang M; Go ML
Eur J Med Chem; 2013 May; 63():378-86. PubMed ID: 23514631
[TBL] [Abstract][Full Text] [Related]
10. Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
Svensson AW; Casey PJ; Young SG; Bergo MO
Methods Enzymol; 2006; 407():144-59. PubMed ID: 16757321
[TBL] [Abstract][Full Text] [Related]
11. Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.
Buchanan MS; Carroll AR; Fechner GA; Boyle A; Simpson MM; Addepalli R; Avery VM; Hooper JN; Su N; Chen H; Quinn RJ
Bioorg Med Chem Lett; 2007 Dec; 17(24):6860-3. PubMed ID: 17964784
[TBL] [Abstract][Full Text] [Related]
12. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.
Kramer K; Harrington EO; Lu Q; Bellas R; Newton J; Sheahan KL; Rounds S
Mol Biol Cell; 2003 Mar; 14(3):848-57. PubMed ID: 12631708
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of ICMT induces endothelial cell apoptosis through GRP94.
Lu Q; Harrington EO; Newton J; Jankowich M; Rounds S
Am J Respir Cell Mol Biol; 2007 Jul; 37(1):20-30. PubMed ID: 17347446
[TBL] [Abstract][Full Text] [Related]
14. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
Winter-Vann AM; Baron RA; Wong W; dela Cruz J; York JD; Gooden DM; Bergo MO; Young SG; Toone EJ; Casey PJ
Proc Natl Acad Sci U S A; 2005 Mar; 102(12):4336-41. PubMed ID: 15784746
[TBL] [Abstract][Full Text] [Related]
15. Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx.
Buchanan MS; Carroll AR; Fechner GA; Boyle A; Simpson M; Addepalli R; Avery VM; Forster PI; Guymer GP; Cheung T; Chen H; Quinn RJ
Phytochemistry; 2008 Jun; 69(9):1886-9. PubMed ID: 18466935
[TBL] [Abstract][Full Text] [Related]
16. Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules.
Baron RA; Peterson YK; Otto JC; Rudolph J; Casey PJ
Biochemistry; 2007 Jan; 46(2):554-60. PubMed ID: 17209565
[TBL] [Abstract][Full Text] [Related]
17. Solid-phase synthesis of Biotin-S-Farnesyl-L-Cysteine, a surrogate substrate for isoprenylcysteine Carboxylmethyltransferase (ICMT).
Stevenson GI; Yong S; Fechner GA; Neve J; Lock A; Avery VM
Bioorg Med Chem Lett; 2013 Oct; 23(20):5671-3. PubMed ID: 23988355
[TBL] [Abstract][Full Text] [Related]
18. Solid-phase synthesis of prenylcysteine analogs.
Donelson JL; Hodges-Loaiza HB; Henriksen BS; Hrycyna CA; Gibbs RA
J Org Chem; 2009 Apr; 74(8):2975-81. PubMed ID: 19320430
[TBL] [Abstract][Full Text] [Related]
19. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).
Judd WR; Slattum PM; Hoang KC; Bhoite L; Valppu L; Alberts G; Brown B; Roth B; Ostanin K; Huang L; Wettstein D; Richards B; Willardsen JA
J Med Chem; 2011 Jul; 54(14):5031-47. PubMed ID: 21661760
[TBL] [Abstract][Full Text] [Related]
20. Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation.
Lu Q; Harrington EO; Hai CM; Newton J; Garber M; Hirase T; Rounds S
Circ Res; 2004 Feb; 94(3):306-15. PubMed ID: 14699010
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
