194 related articles for article (PubMed ID: 21335425)
1. Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.
Wasko BM; Dudakovic A; Hohl RJ
J Pharmacol Exp Ther; 2011 May; 337(2):540-6. PubMed ID: 21335425
[TBL] [Abstract][Full Text] [Related]
2. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation.
Agabiti SS; Li J; Wiemer AJ
Cell Death Dis; 2017 Mar; 8(3):e2678. PubMed ID: 28300835
[TBL] [Abstract][Full Text] [Related]
3. Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
Wiemer AJ; Tong H; Swanson KM; Hohl RJ
Biochem Biophys Res Commun; 2007 Feb; 353(4):921-5. PubMed ID: 17208200
[TBL] [Abstract][Full Text] [Related]
4. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Wiemer AJ; Yu JS; Lamb KM; Hohl RJ; Wiemer DF
Bioorg Med Chem; 2008 Jan; 16(1):390-9. PubMed ID: 17905588
[TBL] [Abstract][Full Text] [Related]
5. Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors.
Haney SL; Wills VS; Wiemer DF; Holstein SA
Molecules; 2017 May; 22(6):. PubMed ID: 28555000
[TBL] [Abstract][Full Text] [Related]
6. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.
Wasko BM; Smits JP; Shull LW; Wiemer DF; Hohl RJ
J Lipid Res; 2011 Nov; 52(11):1957-64. PubMed ID: 21903868
[TBL] [Abstract][Full Text] [Related]
7. Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration.
Dudakovic A; Tong H; Hohl RJ
Invest New Drugs; 2011 Oct; 29(5):912-20. PubMed ID: 20480384
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes.
Dudakovic A; Wiemer AJ; Lamb KM; Vonnahme LA; Dietz SE; Hohl RJ
J Pharmacol Exp Ther; 2008 Mar; 324(3):1028-36. PubMed ID: 18083912
[TBL] [Abstract][Full Text] [Related]
9. In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.
Reilly JE; Zhou X; Tong H; Kuder CH; Wiemer DF; Hohl RJ
Biochem Pharmacol; 2015 Jul; 96(2):83-92. PubMed ID: 25952057
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of a series of aromatic bisphosphonates.
Barney RJ; Wasko BM; Dudakovic A; Hohl RJ; Wiemer DF
Bioorg Med Chem; 2010 Oct; 18(20):7212-20. PubMed ID: 20832326
[TBL] [Abstract][Full Text] [Related]
11. Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.
Allen C; Kortagere S; Tong H; Matthiesen RA; Metzger JI; Wiemer DF; Holstein SA
Mol Pharmacol; 2017 Mar; 91(3):229-236. PubMed ID: 28057800
[TBL] [Abstract][Full Text] [Related]
12. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Haney SL; Varney ML; Chhonker Y; Talmon G; Smith LM; Murry DJ; Holstein SA
Pharmacol Res; 2021 May; 167():105528. PubMed ID: 33667685
[TBL] [Abstract][Full Text] [Related]
13. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells.
Dykstra KM; Allen C; Born EJ; Tong H; Holstein SA
Oncotarget; 2015 Dec; 6(39):41535-49. PubMed ID: 26595805
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS.
Henneman L; van Cruchten AG; Kulik W; Waterham HR
Biochim Biophys Acta; 2011 Apr; 1811(4):227-33. PubMed ID: 21237288
[TBL] [Abstract][Full Text] [Related]
15. A new motif for inhibitors of geranylgeranyl diphosphate synthase.
Foust BJ; Allen C; Holstein SA; Wiemer DF
Bioorg Med Chem; 2016 Aug; 24(16):3734-41. PubMed ID: 27338660
[TBL] [Abstract][Full Text] [Related]
16. Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.
Wills VS; Metzger JI; Allen C; Varney ML; Wiemer DF; Holstein SA
Bioorg Med Chem; 2017 Apr; 25(8):2437-2444. PubMed ID: 28302510
[TBL] [Abstract][Full Text] [Related]
17. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.
Wiemer AJ; Yu JS; Shull LW; Barney RJ; Wasko BM; Lamb KM; Hohl RJ; Wiemer DF
Bioorg Med Chem; 2008 Apr; 16(7):3652-60. PubMed ID: 18308574
[TBL] [Abstract][Full Text] [Related]
18. Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target.
Muehlebach ME; Holstein SA
Clin Transl Med; 2023 Jan; 13(1):e1167. PubMed ID: 36650113
[TBL] [Abstract][Full Text] [Related]
19. Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells.
Parikh A; Childress C; Deitrick K; Lin Q; Rukstalis D; Yang W
Prostate; 2010 Jun; 70(9):971-81. PubMed ID: 20135644
[TBL] [Abstract][Full Text] [Related]
20. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
Bergstrom JD; Bostedor RG; Masarachia PJ; Reszka AA; Rodan G
Arch Biochem Biophys; 2000 Jan; 373(1):231-41. PubMed ID: 10620343
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
