BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

359 related articles for article (PubMed ID: 21335549)

  • 1. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
    Tian YM; Yeoh KK; Lee MK; Eriksson T; Kessler BM; Kramer HB; Edelmann MJ; Willam C; Pugh CW; Schofield CJ; Ratcliffe PJ
    J Biol Chem; 2011 Apr; 286(15):13041-51. PubMed ID: 21335549
    [TBL] [Abstract][Full Text] [Related]  

  • 2. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
    Masson N; Ratcliffe PJ
    J Cell Sci; 2003 Aug; 116(Pt 15):3041-9. PubMed ID: 12829734
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HIF hydroxylation and cellular oxygen sensing.
    Metzen E; Ratcliffe PJ
    Biol Chem; 2004; 385(3-4):223-30. PubMed ID: 15134335
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.
    Sang N; Fang J; Srinivas V; Leshchinsky I; Caro J
    Mol Cell Biol; 2002 May; 22(9):2984-92. PubMed ID: 11940656
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of HIF: prolyl hydroxylases.
    Stolze IP; Mole DR; Ratcliffe PJ
    Novartis Found Symp; 2006; 272():15-25; discussion 25-36. PubMed ID: 16686427
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
    Elvidge GP; Glenny L; Appelhoff RJ; Ratcliffe PJ; Ragoussis J; Gleadle JM
    J Biol Chem; 2006 Jun; 281(22):15215-26. PubMed ID: 16565084
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR; Maxwell PH; Pugh CW; Ratcliffe PJ
    IUBMB Life; 2001 Jul; 52(1-2):43-7. PubMed ID: 11795592
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
    Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ
    J Biol Chem; 2002 Jul; 277(29):26351-5. PubMed ID: 12042299
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modulation of the Hypoxic Response.
    Pugh CW
    Adv Exp Med Biol; 2016; 903():259-71. PubMed ID: 27343102
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P; Mole DR; Tian YM; Wilson MI; Gielbert J; Gaskell SJ; von Kriegsheim A; Hebestreit HF; Mukherji M; Schofield CJ; Maxwell PH; Pugh CW; Ratcliffe PJ
    Science; 2001 Apr; 292(5516):468-72. PubMed ID: 11292861
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    Wu Y; Li Z; McDonough MA; Schofield CJ; Zhang X
    J Med Chem; 2021 Jun; 64(11):7189-7209. PubMed ID: 34029087
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
    Strowitzki MJ; Cummins EP; Taylor CT
    Cells; 2019 Apr; 8(5):. PubMed ID: 31035491
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
    Hewitson KS; Schofield CJ; Ratcliffe PJ
    Methods Enzymol; 2007; 435():25-42. PubMed ID: 17998047
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
    Masson N; Willam C; Maxwell PH; Pugh CW; Ratcliffe PJ
    EMBO J; 2001 Sep; 20(18):5197-206. PubMed ID: 11566883
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of clioquinol analogues on the hypoxia-inducible factor pathway and intracelullar mobilization of metal ions.
    Kim SY; Lee MJ; Kim JW; Na YR; Lee HY; Cho H; Lee KB; Lee YM; Lee C; Park H; Yang EG
    Biol Pharm Bull; 2012; 35(12):2160-9. PubMed ID: 23207768
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E; Davies SL; Yeoh KK; Schofield CJ
    Biochem J; 2010 Mar; 427(1):135-42. PubMed ID: 20055761
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
    Hewitson KS; McNeill LA; Schofield CJ
    Curr Pharm Des; 2004; 10(8):821-33. PubMed ID: 15032687
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.
    Lee HY; Lee T; Lee N; Yang EG; Lee C; Lee J; Moon EY; Ha J; Park H
    Carcinogenesis; 2011 May; 32(5):703-12. PubMed ID: 21335603
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.