BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

268 related articles for article (PubMed ID: 21341745)

  • 1. A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
    Broccatelli F; Carosati E; Neri A; Frosini M; Goracci L; Oprea TI; Cruciani G
    J Med Chem; 2011 Mar; 54(6):1740-51. PubMed ID: 21341745
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).
    Teodori E; Dei S; Martelli C; Scapecchi S; Gualtieri F
    Curr Drug Targets; 2006 Jul; 7(7):893-909. PubMed ID: 16842220
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model.
    Langer T; Eder M; Hoffmann RD; Chiba P; Ecker GF
    Arch Pharm (Weinheim); 2004 Jun; 337(6):317-27. PubMed ID: 15188221
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Computational models for identifying potential P-glycoprotein substrates and inhibitors.
    Crivori P; Reinach B; Pezzetta D; Poggesi I
    Mol Pharm; 2006; 3(1):33-44. PubMed ID: 16686367
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
    Sharom FJ
    Biochem Cell Biol; 2006 Dec; 84(6):979-92. PubMed ID: 17215884
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.
    Ding PR; Tiwari AK; Ohnuma S; Lee JW; An X; Dai CL; Lu QS; Singh S; Yang DH; Talele TT; Ambudkar SV; Chen ZS
    PLoS One; 2011 Apr; 6(4):e19329. PubMed ID: 21552528
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A pharmacodynamic study of the P-glycoprotein antagonist CBT-1® in combination with paclitaxel in solid tumors.
    Kelly RJ; Robey RW; Chen CC; Draper D; Luchenko V; Barnett D; Oldham RK; Caluag Z; Frye AR; Steinberg SM; Fojo T; Bates SE
    Oncologist; 2012; 17(4):512. PubMed ID: 22416063
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.
    Shukla S; Robey RW; Bates SE; Ambudkar SV
    Drug Metab Dispos; 2009 Feb; 37(2):359-65. PubMed ID: 18971320
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation.
    Maki N; Hafkemeyer P; Dey S
    J Biol Chem; 2003 May; 278(20):18132-9. PubMed ID: 12642584
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.
    Loor F; Tiberghien F; Wenandy T; Didier A; Traber R
    J Med Chem; 2002 Oct; 45(21):4598-612. PubMed ID: 12361387
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mini review on molecular modeling of P-glycoprotein (Pgp).
    Ha SN; Hochman J; Sheridan RP
    Curr Top Med Chem; 2007; 7(15):1525-9. PubMed ID: 17897039
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Prediction of promiscuous p-glycoprotein inhibition using a novel machine learning scheme.
    Leong MK; Chen HB; Shih YH
    PLoS One; 2012; 7(3):e33829. PubMed ID: 22439003
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reconstitution and functional studies of hamster P-glycoprotein in giant liposomes.
    Park S; Majd S
    PLoS One; 2018; 13(6):e0199279. PubMed ID: 29912971
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier.
    Nagasaka Y; Oda K; Iwatsubo T; Kawamura A; Usui T
    Biopharm Drug Dispos; 2012 Sep; 33(6):304-15. PubMed ID: 22847220
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.
    Fong WF; Shen XL; Globisch C; Wiese M; Chen GY; Zhu GY; Yu ZL; Tse AK; Hu YJ
    Bioorg Med Chem; 2008 Apr; 16(7):3694-703. PubMed ID: 18313307
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.
    Wise JG
    Biochemistry; 2012 Jun; 51(25):5125-41. PubMed ID: 22647192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism.
    Walter RB; Pirga JL; Cronk MR; Mayer S; Appelbaum FR; Banker DE
    Blood; 2005 Nov; 106(10):3584-93. PubMed ID: 16051742
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance.
    Kaiser D; Smiesko M; Kopp S; Chiba P; Ecker GF
    Med Chem; 2005 Sep; 1(5):431-44. PubMed ID: 16787327
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.
    Ecker GF; Csaszar E; Kopp S; Plagens B; Holzer W; Ernst W; Chiba P
    Mol Pharmacol; 2002 Mar; 61(3):637-48. PubMed ID: 11854445
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Computational models for prediction of interactions with ABC-transporters.
    Ecker GF; Stockner T; Chiba P
    Drug Discov Today; 2008 Apr; 13(7-8):311-7. PubMed ID: 18405843
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.