These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

312 related articles for article (PubMed ID: 21344906)

  • 1. Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
    Ishikawa M; Hashimoto Y
    J Med Chem; 2011 Mar; 54(6):1539-54. PubMed ID: 21344906
    [No Abstract]   [Full Text] [Related]  

  • 2. Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity.
    Hill AP; Young RJ
    Drug Discov Today; 2010 Aug; 15(15-16):648-55. PubMed ID: 20570751
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Escape from flatland: increasing saturation as an approach to improving clinical success.
    Lovering F; Bikker J; Humblet C
    J Med Chem; 2009 Nov; 52(21):6752-6. PubMed ID: 19827778
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Predicting aqueous solubility from structure.
    Delaney JS
    Drug Discov Today; 2005 Feb; 10(4):289-95. PubMed ID: 15708748
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prediction of aqueous solubility from SCRATCH.
    Jain P; Yalkowsky SH
    Int J Pharm; 2010 Jan; 385(1-2):1-5. PubMed ID: 19819319
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New QSPR study for the prediction of aqueous solubility of drug-like compounds.
    Duchowicz PR; Talevi A; Bruno-Blanch LE; Castro EA
    Bioorg Med Chem; 2008 Sep; 16(17):7944-55. PubMed ID: 18701302
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Improvement in aqueous solubility achieved via small molecular changes.
    Walker MA
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5100-5108. PubMed ID: 29100802
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Deep understanding of structure-solubility relationship for a diverse set of organic compounds using matched molecular pairs.
    Zhang L; Zhu H; Mathiowetz A; Gao H
    Bioorg Med Chem; 2011 Oct; 19(19):5763-70. PubMed ID: 21906951
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigation of the relationship between topology and selectivity for druglike molecules.
    Yang Y; Chen H; Nilsson I; Muresan S; Engkvist O
    J Med Chem; 2010 Nov; 53(21):7709-14. PubMed ID: 20942392
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.
    Kasuga J; Ishikawa M; Yonehara M; Makishima M; Hashimoto Y; Miyachi H
    Bioorg Med Chem; 2010 Oct; 18(20):7164-73. PubMed ID: 20843696
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A computational model for the prediction of aqueous solubility that includes crystal packing, intrinsic solubility, and ionization effects.
    Johnson SR; Chen XQ; Murphy D; Gudmundsson O
    Mol Pharm; 2007; 4(4):513-23. PubMed ID: 17539661
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Enhancement of the water solubility of flavone glycosides by disruption of molecular planarity of the aglycone moiety.
    Lewin G; Maciuk A; Moncomble A; Cornard JP
    J Nat Prod; 2013 Jan; 76(1):8-12. PubMed ID: 23249276
    [TBL] [Abstract][Full Text] [Related]  

  • 13. QSAR-based solubility model for drug-like compounds.
    Gozalbes R; Pineda-Lucena A
    Bioorg Med Chem; 2010 Oct; 18(19):7078-84. PubMed ID: 20810286
    [TBL] [Abstract][Full Text] [Related]  

  • 14. On-the-fly selection of a training set for aqueous solubility prediction.
    Zhang H; Ando HY; Chen L; Lee PH
    Mol Pharm; 2007; 4(4):489-97. PubMed ID: 17628076
    [TBL] [Abstract][Full Text] [Related]  

  • 15. What do medicinal chemists actually make? A 50-year retrospective.
    Walters WP; Green J; Weiss JR; Murcko MA
    J Med Chem; 2011 Oct; 54(19):6405-16. PubMed ID: 21755928
    [No Abstract]   [Full Text] [Related]  

  • 16. Computational aqueous solubility prediction for drug-like compounds in congeneric series.
    Du-Cuny L; Huwyler J; Wiese M; Kansy M
    Eur J Med Chem; 2008 Mar; 43(3):501-12. PubMed ID: 17574307
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Modelling, solubility and pK(a) of five sparingly soluble drugs.
    Domańska U; Pobudkowska A; Pelczarska A; Zukowski L
    Int J Pharm; 2011 Jan; 403(1-2):115-22. PubMed ID: 21034801
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intramolecular hydrogen bonding in medicinal chemistry.
    Kuhn B; Mohr P; Stahl M
    J Med Chem; 2010 Mar; 53(6):2601-11. PubMed ID: 20175530
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
    Leach AG; Jones HD; Cosgrove DA; Kenny PW; Ruston L; MacFaul P; Wood JM; Colclough N; Law B
    J Med Chem; 2006 Nov; 49(23):6672-82. PubMed ID: 17154498
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quo vadis, virtual screening? A comprehensive survey of prospective applications.
    Ripphausen P; Nisius B; Peltason L; Bajorath J
    J Med Chem; 2010 Dec; 53(24):8461-7. PubMed ID: 20929257
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 16.