157 related articles for article (PubMed ID: 21357300)
1. INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Vernachio JH; Bleiman B; Bryant KD; Chamberlain S; Hunley D; Hutchins J; Ames B; Gorovits E; Ganguly B; Hall A; Kolykhalov A; Liu Y; Muhammad J; Raja N; Walters CR; Wang J; Williams K; Patti JM; Henson G; Madela K; Aljarah M; Gilles A; McGuigan C
Antimicrob Agents Chemother; 2011 May; 55(5):1843-51. PubMed ID: 21357300
[TBL] [Abstract][Full Text] [Related]
2. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus.
Good SS; Moussa A; Zhou XJ; Pietropaolo K; Sommadossi JP
PLoS One; 2020; 15(1):e0227104. PubMed ID: 31914458
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
McGuigan C; Madela K; Aljarah M; Gilles A; Brancale A; Zonta N; Chamberlain S; Vernachio J; Hutchins J; Hall A; Ames B; Gorovits E; Ganguly B; Kolykhalov A; Wang J; Muhammad J; Patti JM; Henson G
Bioorg Med Chem Lett; 2010 Aug; 20(16):4850-4. PubMed ID: 20637609
[TBL] [Abstract][Full Text] [Related]
4. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM; Murakami E; Espiritu C; Steuer HM; Niu C; Keilman M; Bao H; Zennou V; Bourne N; Julander JG; Morrey JD; Smee DF; Frick DN; Heck JA; Wang P; Nagarathnam D; Ross BS; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2010 Aug; 54(8):3187-96. PubMed ID: 20516278
[TBL] [Abstract][Full Text] [Related]
5. Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Kirschberg TA; Metobo S; Clarke MO; Aktoudianakis V; Babusis D; Barauskas O; Birkus G; Butler T; Byun D; Chin G; Doerffler E; Edwards TE; Fenaux M; Lee R; Lew W; Mish MR; Murakami E; Park Y; Squires NH; Tirunagari N; Wang T; Whitcomb M; Xu J; Yang H; Ye H; Zhang L; Appleby TC; Feng JY; Ray AS; Cho A; Kim CU
Bioorg Med Chem Lett; 2017 Apr; 27(8):1840-1847. PubMed ID: 28274633
[TBL] [Abstract][Full Text] [Related]
6. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
Lam AM; Espiritu C; Bansal S; Micolochick Steuer HM; Zennou V; Otto MJ; Furman PA
J Virol; 2011 Dec; 85(23):12334-42. PubMed ID: 21957306
[TBL] [Abstract][Full Text] [Related]
7. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
McGuigan C; Gilles A; Madela K; Aljarah M; Holl S; Jones S; Vernachio J; Hutchins J; Ames B; Bryant KD; Gorovits E; Ganguly B; Hunley D; Hall A; Kolykhalov A; Liu Y; Muhammad J; Raja N; Walters R; Wang J; Chamberlain S; Henson G
J Med Chem; 2010 Jul; 53(13):4949-57. PubMed ID: 20527890
[TBL] [Abstract][Full Text] [Related]
8. Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
Furman PA; Murakami E; Niu C; Lam AM; Espiritu C; Bansal S; Bao H; Tolstykh T; Micolochick Steuer H; Keilman M; Zennou V; Bourne N; Veselenak RL; Chang W; Ross BS; Du J; Otto MJ; Sofia MJ
Antiviral Res; 2011 Aug; 91(2):120-32. PubMed ID: 21600932
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Feng JY; Cheng G; Perry J; Barauskas O; Xu Y; Fenaux M; Eng S; Tirunagari N; Peng B; Yu M; Tian Y; Lee YJ; Stepan G; Lagpacan LL; Jin D; Hung M; Ku KS; Han B; Kitrinos K; Perron M; Birkus G; Wong KA; Zhong W; Kim CU; Carey A; Cho A; Ray AS
Antimicrob Agents Chemother; 2014; 58(4):1930-42. PubMed ID: 24419349
[TBL] [Abstract][Full Text] [Related]
10. Phosphoramidate prodrugs deliver with potency against hepatitis C virus.
Mehellou Y
ChemMedChem; 2010 Nov; 5(11):1841-2. PubMed ID: 20865770
[No Abstract] [Full Text] [Related]
11. Intracellular metabolism and potential cardiotoxicity of a β-D-2'-
Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ; Schinazi RF
Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):204-224. PubMed ID: 31595843
[TBL] [Abstract][Full Text] [Related]
12. The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
McGuigan C; Perrone P; Madela K; Neyts J
Bioorg Med Chem Lett; 2009 Aug; 19(15):4316-20. PubMed ID: 19523820
[TBL] [Abstract][Full Text] [Related]
13. β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
Zhou L; Zhang HW; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH; Amblard F; Bobeck D; Detorio M; Coats SJ; Schinazi RF
J Med Chem; 2015 Apr; 58(8):3445-58. PubMed ID: 25849312
[TBL] [Abstract][Full Text] [Related]
14. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
McGuigan C; Madela K; Aljarah M; Bourdin C; Arrica M; Barrett E; Jones S; Kolykhalov A; Bleiman B; Bryant KD; Ganguly B; Gorovits E; Henson G; Hunley D; Hutchins J; Muhammad J; Obikhod A; Patti J; Walters CR; Wang J; Vernachio J; Ramamurty CV; Battina SK; Chamberlain S
J Med Chem; 2011 Dec; 54(24):8632-45. PubMed ID: 22039920
[TBL] [Abstract][Full Text] [Related]
15. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
Rondla R; Coats SJ; McBrayer TR; Grier J; Johns M; Tharnish PM; Whitaker T; Zhou L; Schinazi RF
Antivir Chem Chemother; 2009 Oct; 20(2):99-106. PubMed ID: 19843980
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Lam AM; Espiritu C; Murakami E; Zennou V; Bansal S; Micolochick Steuer HM; Niu C; Keilman M; Bao H; Bourne N; Veselenak RL; Reddy PG; Chang W; Du J; Nagarathnam D; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2011 Jun; 55(6):2566-75. PubMed ID: 21444700
[TBL] [Abstract][Full Text] [Related]
17. Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
McGuigan C; Madela K; Aljarah M; Gilles A; Battina SK; Ramamurty CV; Srinivas Rao C; Vernachio J; Hutchins J; Hall A; Kolykhalov A; Henson G; Chamberlain S
Bioorg Med Chem Lett; 2011 Oct; 21(19):6007-12. PubMed ID: 21856153
[TBL] [Abstract][Full Text] [Related]
18. Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation.
Zhen L; Dai L; Wen X; Yao L; Jin X; Yang XW; Zhao W; Yu SQ; Yuan H; Wang G; Sun H
J Med Chem; 2017 Jul; 60(14):6077-6088. PubMed ID: 28650160
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Kirschberg TA; Mish MR; Zhang L; Squires NH; Wang KY; Cho A; Feng JY; Fenaux M; Babusis D; Park Y; Ray AS; Kim CU
Bioorg Med Chem Lett; 2015 Mar; 25(5):1040-3. PubMed ID: 25650256
[TBL] [Abstract][Full Text] [Related]
20. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
Sofia MJ; Bao D; Chang W; Du J; Nagarathnam D; Rachakonda S; Reddy PG; Ross BS; Wang P; Zhang HR; Bansal S; Espiritu C; Keilman M; Lam AM; Steuer HM; Niu C; Otto MJ; Furman PA
J Med Chem; 2010 Oct; 53(19):7202-18. PubMed ID: 20845908
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
