These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
25. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. Liu Q; Waltz S; Woodruff G; Ouyang J; Israel MA; Herrera C; Sarsoza F; Tanzi RE; Koo EH; Ringman JM; Goldstein LS; Wagner SL; Yuan SH JAMA Neurol; 2014 Dec; 71(12):1481-9. PubMed ID: 25285942 [TBL] [Abstract][Full Text] [Related]
26. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo. Huang Y; Li T; Eatherton A; Mitchell WL; Rong N; Ye L; Yang XJ; Jin S; Ding Y; Zhang J; Li Y; Wu Y; Jin Y; Sang Y; Cheng Z; Browne ER; Harrison DC; Hussain I; Wan Z; Hall A; Lau LF; Matsuoka Y Neuropharmacology; 2013 Jul; 70():278-86. PubMed ID: 23485401 [TBL] [Abstract][Full Text] [Related]
27. CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators. Watahiki H; Yagishita S; Futai E; Ishiura S Neurosci Lett; 2012 Sep; 526(2):96-9. PubMed ID: 22940081 [TBL] [Abstract][Full Text] [Related]
28. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. Pozdnyakov N; Murrey HE; Crump CJ; Pettersson M; Ballard TE; Am Ende CW; Ahn K; Li YM; Bales KR; Johnson DS J Biol Chem; 2013 Apr; 288(14):9710-9720. PubMed ID: 23396974 [TBL] [Abstract][Full Text] [Related]
29. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Ling IF; Golde TE; Galasko DR; Koo EH Alzheimers Res Ther; 2015; 7(1):55. PubMed ID: 26244059 [TBL] [Abstract][Full Text] [Related]
30. Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds. Czirr E; Weggen S Neurodegener Dis; 2006; 3(4-5):298-304. PubMed ID: 17047371 [TBL] [Abstract][Full Text] [Related]
31. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Moehlmann T; Winkler E; Xia X; Edbauer D; Murrell J; Capell A; Kaether C; Zheng H; Ghetti B; Haass C; Steiner H Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8025-30. PubMed ID: 12048239 [TBL] [Abstract][Full Text] [Related]
32. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302 [TBL] [Abstract][Full Text] [Related]
33. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513 [TBL] [Abstract][Full Text] [Related]
34. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Jung JI; Ran Y; Cruz PE; Rosario AM; Ladd TB; Kukar TL; Koo EH; Felsenstein KM; Golde TE Biochemistry; 2014 Apr; 53(12):1947-57. PubMed ID: 24620716 [TBL] [Abstract][Full Text] [Related]
35. Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation. Trambauer J; Rodríguez Sarmiento RM; Fukumori A; Feederle R; Baumann K; Steiner H EMBO Rep; 2020 Jan; 21(1):e47996. PubMed ID: 31762188 [TBL] [Abstract][Full Text] [Related]
36. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Ohki Y; Shimada N; Tominaga A; Osawa S; Higo T; Yokoshima S; Fukuyama T; Tomita T; Iwatsubo T Mol Neurodegener; 2014 Jan; 9():7. PubMed ID: 24410857 [TBL] [Abstract][Full Text] [Related]
37. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. Liu L; Lauro BM; Wolfe MS; Selkoe DJ J Biol Chem; 2021; 296():100393. PubMed ID: 33571524 [TBL] [Abstract][Full Text] [Related]
38. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study. Yesuvadian R; Krishnamoorthy J; Ramamoorthy A; Bhunia A Biochem Biophys Res Commun; 2014 May; 447(4):590-5. PubMed ID: 24747079 [TBL] [Abstract][Full Text] [Related]
39. Identification of gamma-secretase inhibitor potency determinants on presenilin. Zhao B; Yu M; Neitzel M; Marugg J; Jagodzinski J; Lee M; Hu K; Schenk D; Yednock T; Basi G J Biol Chem; 2008 Feb; 283(5):2927-38. PubMed ID: 18032377 [TBL] [Abstract][Full Text] [Related]