BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

269 related articles for article (PubMed ID: 21362439)

  • 1. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.
    Xia M; Shahane SA; Huang R; Titus SA; Shum E; Zhao Y; Southall N; Zheng W; Witt KL; Tice RR; Austin CP
    Toxicol Appl Pharmacol; 2011 May; 252(3):250-8. PubMed ID: 21362439
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.
    Titus SA; Beacham D; Shahane SA; Southall N; Xia M; Huang R; Hooten E; Zhao Y; Shou L; Austin CP; Zheng W
    Anal Biochem; 2009 Nov; 394(1):30-8. PubMed ID: 19583963
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride.
    Long Y; Lin Z; Xia M; Zheng W; Li Z
    Toxicol Appl Pharmacol; 2013 Mar; 267(2):155-66. PubMed ID: 23313619
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.
    Huang XP; Mangano T; Hufeisen S; Setola V; Roth BL
    Assay Drug Dev Technol; 2010 Dec; 8(6):727-42. PubMed ID: 21158687
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.
    Schmalhofer WA; Swensen AM; Thomas BS; Felix JP; Haedo RJ; Solly K; Kiss L; Kaczorowski GJ; Garcia ML
    Assay Drug Dev Technol; 2010 Dec; 8(6):714-26. PubMed ID: 21158686
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide.
    Long Y; Chen W; Lin Z; Sun H; Xia M; Zheng W; Li Z
    Eur J Pharmacol; 2014 Aug; 737():202-9. PubMed ID: 24846011
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
    Potet F; Lorinc AN; Chaigne S; Hopkins CR; Venkataraman R; Stepanovic SZ; Lewis LM; Days E; Sidorov VY; Engers DW; Zou B; Afshartous D; George AL; Campbell CM; Balser JR; Li M; Baudenbacher FJ; Lindsley CW; Weaver CD; Kupershmidt S
    J Biol Chem; 2012 Nov; 287(47):39613-25. PubMed ID: 23033485
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
    Ficker E; Obejero-Paz CA; Zhao S; Brown AM
    J Biol Chem; 2002 Feb; 277(7):4989-98. PubMed ID: 11741928
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation.
    Guo L; Guthrie H
    J Pharmacol Toxicol Methods; 2005; 52(1):123-35. PubMed ID: 15936217
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of human Ether-à-go-go related gene screening assays based on IonWorks Quattro and thallium flux.
    Bridal TR; Margulis M; Wang X; Donio M; Sorota S
    Assay Drug Dev Technol; 2010 Dec; 8(6):755-65. PubMed ID: 20658944
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Propofol inhibits hERG K
    Han SN; Jing Y; Yang LL; Zhang Z; Zhang LR
    Eur J Pharmacol; 2016 Nov; 791():168-178. PubMed ID: 27575519
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay.
    Qu Y; Gao B; Fang M; Vargas HM
    J Pharmacol Toxicol Methods; 2013; 68(1):74-81. PubMed ID: 23518063
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel.
    Park MH; Lee SH; Chu DH; Won KH; Choi BH; Choe H; Jo SH
    J Pharmacol Sci; 2013 Sep; 123(1):67-77. PubMed ID: 24005046
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.
    Ridley JM; Milnes JT; Hancox JC; Witchel HJ
    J Mol Cell Cardiol; 2006 Jan; 40(1):107-18. PubMed ID: 16288909
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
    Thomas D; Karle CA; Kiehn J
    Curr Pharm Des; 2006; 12(18):2271-83. PubMed ID: 16787254
    [TBL] [Abstract][Full Text] [Related]  

  • 16. hERG channel blockade by externally applied quaternary ammonium derivatives.
    Choi KH; Song C; Shin D; Park S
    Biochim Biophys Acta; 2011 Jun; 1808(6):1560-6. PubMed ID: 21320466
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.
    Milnes JT; Witchel HJ; Leaney JL; Leishman DJ; Hancox JC
    J Pharmacol Toxicol Methods; 2010; 61(2):178-91. PubMed ID: 20172036
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking.
    Wang L; Wible BA; Wan X; Ficker E
    J Pharmacol Exp Ther; 2007 Feb; 320(2):525-34. PubMed ID: 17095614
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recent developments in computational prediction of HERG blockage.
    Wang S; Li Y; Xu L; Li D; Hou T
    Curr Top Med Chem; 2013; 13(11):1317-26. PubMed ID: 23675938
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.
    Gualdani R; Cavalluzzi MM; Tadini-Buoninsegni F; Convertino M; Gailly P; Stary-Weinzinger A; Lentini G
    Cell Physiol Biochem; 2018; 45(6):2233-2245. PubMed ID: 29550817
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.