BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

287 related articles for article (PubMed ID: 21364679)

  • 1. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy.
    Heidari N; Hicks MA; Harada H
    Cell Death Dis; 2010 Sep; 1(9):e76. PubMed ID: 21364679
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance.
    Bonapace L; Bornhauser BC; Schmitz M; Cario G; Ziegler U; Niggli FK; Schäfer BW; Schrappe M; Stanulla M; Bourquin JP
    J Clin Invest; 2010 Apr; 120(4):1310-23. PubMed ID: 20200450
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.
    Sharma A; Singh K; Mazumder S; Hill BT; Kalaycio M; Almasan A
    Cell Death Dis; 2013 May; 4(5):e628. PubMed ID: 23681223
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.
    McCoy F; Hurwitz J; McTavish N; Paul I; Barnes C; O'Hagan B; Odrzywol K; Murray J; Longley D; McKerr G; Fennell DA
    Cell Death Dis; 2010 Dec; 1(12):e108. PubMed ID: 21368880
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
    Martin AP; Mitchell C; Rahmani M; Nephew KP; Grant S; Dent P
    Cancer Biol Ther; 2009 Nov; 8(21):2084-96. PubMed ID: 19823038
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
    Nguyen M; Marcellus RC; Roulston A; Watson M; Serfass L; Murthy Madiraju SR; Goulet D; Viallet J; Bélec L; Billot X; Acoca S; Purisima E; Wiegmans A; Cluse L; Johnstone RW; Beauparlant P; Shore GC
    Proc Natl Acad Sci U S A; 2007 Dec; 104(49):19512-7. PubMed ID: 18040043
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.
    Pérez-Galán P; Roué G; Villamor N; Campo E; Colomer D
    Blood; 2007 May; 109(10):4441-9. PubMed ID: 17227835
    [TBL] [Abstract][Full Text] [Related]  

  • 8. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.
    Schwartz-Roberts JL; Shajahan AN; Cook KL; Wärri A; Abu-Asab M; Clarke R
    Mol Cancer Ther; 2013 Apr; 12(4):448-59. PubMed ID: 23395885
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.
    Lindqvist LM; Heinlein M; Huang DC; Vaux DL
    Proc Natl Acad Sci U S A; 2014 Jun; 111(23):8512-7. PubMed ID: 24912196
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak.
    Melarangi T; Zhuang J; Lin K; Rockliffe N; Bosanquet AG; Oates M; Slupsky JR; Pettitt AR
    Cell Death Dis; 2012 Aug; 3(8):e372. PubMed ID: 22898870
    [TBL] [Abstract][Full Text] [Related]  

  • 11. RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.
    Su JC; Tseng PH; Hsu CY; Tai WT; Huang JW; Ko CH; Lin MW; Liu CY; Chen KF; Shiau CW
    Oncotarget; 2014 Jul; 5(13):4909-19. PubMed ID: 24952874
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.
    Basit F; Cristofanon S; Fulda S
    Cell Death Differ; 2013 Sep; 20(9):1161-73. PubMed ID: 23744296
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells.
    Jiang L; Xu L; Xie J; Li S; Guan Y; Zhang Y; Hou Z; Guo T; Shu X; Wang C; Fan W; Si Y; Yang Y; Kang Z; Fang M; Liu Q
    Cancer Biol Ther; 2015; 16(3):466-76. PubMed ID: 25778879
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM.
    Rambal AA; Panaguiton ZL; Kramer L; Grant S; Harada H
    Leukemia; 2009 Oct; 23(10):1744-54. PubMed ID: 19404317
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis.
    Martínez-Paniagua MA; Baritaki S; Huerta-Yepez S; Ortiz-Navarrete VF; González-Bonilla C; Bonavida B; Vega MI
    Cell Cycle; 2011 Aug; 10(16):2792-805. PubMed ID: 21822052
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).
    Konopleva M; Watt J; Contractor R; Tsao T; Harris D; Estrov Z; Bornmann W; Kantarjian H; Viallet J; Samudio I; Andreeff M
    Cancer Res; 2008 May; 68(9):3413-20. PubMed ID: 18451169
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.
    Rahmani M; Aust MM; Attkisson E; Williams DC; Ferreira-Gonzalez A; Grant S
    Blood; 2012 Jun; 119(25):6089-98. PubMed ID: 22446485
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells.
    Ha EJ; Kim KY; Kim CE; Jun DY; Kim YH
    Oxid Med Cell Longev; 2019; 2019():7989276. PubMed ID: 31827702
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.
    Spijkers-Hagelstein JA; Schneider P; Pinhanços SM; Garrido Castro P; Pieters R; Stam RW
    Eur J Cancer; 2014 Jun; 50(9):1665-74. PubMed ID: 24703900
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.
    Lian J; Wu X; He F; Karnak D; Tang W; Meng Y; Xiang D; Ji M; Lawrence TS; Xu L
    Cell Death Differ; 2011 Jan; 18(1):60-71. PubMed ID: 20577262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.