BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

293 related articles for article (PubMed ID: 21368103)

  • 1. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
    Tian Y; Bustos V; Flajolet M; Greengard P
    FASEB J; 2011 Jun; 25(6):1934-42. PubMed ID: 21368103
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.
    Tian Y; Chang JC; Fan EY; Flajolet M; Greengard P
    Proc Natl Acad Sci U S A; 2013 Oct; 110(42):17071-6. PubMed ID: 24067654
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
    Yamamoto F; Taniguchi K; Mamada N; Tamaoka A; Kametani F; Lakshmana MK; Araki W
    Neuroscience; 2019 Mar; 402():11-22. PubMed ID: 30677488
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells.
    Lee HR; Shin HK; Park SY; Kim HY; Bae SS; Lee WS; Rhim BY; Hong KW; Kim CD
    PLoS One; 2015; 10(8):e0134486. PubMed ID: 26244661
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
    Tamboli IY; Hampel H; Tien NT; Tolksdorf K; Breiden B; Mathews PM; Saftig P; Sandhoff K; Walter J
    J Neurosci; 2011 Feb; 31(5):1837-49. PubMed ID: 21289194
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation.
    Tian Y; Chang JC; Greengard P; Flajolet M
    Autophagy; 2014 Apr; 10(4):694-6. PubMed ID: 24447917
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy.
    Cavieres VA; González A; Muñoz VC; Yefi CP; Bustamante HA; Barraza RR; Tapia-Rojas C; Otth C; Barrera MJ; González C; Mardones GA; Inestrosa NC; Burgos PV
    PLoS One; 2015; 10(8):e0136313. PubMed ID: 26308941
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ.
    Marttinen M; Ferreira CB; Paldanius KMA; Takalo M; Natunen T; Mäkinen P; Leppänen L; Leinonen V; Tanigaki K; Kang G; Hiroi N; Soininen H; Rilla K; Haapasalo A; Hiltunen M
    Cells; 2020 Nov; 9(11):. PubMed ID: 33203136
    [TBL] [Abstract][Full Text] [Related]  

  • 10. APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
    Maulik M; Peake K; Chung J; Wang Y; Vance JE; Kar S
    Hum Mol Genet; 2015 Dec; 24(24):7132-50. PubMed ID: 26433932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.
    Araki W; Kume H; Oda A; Tamaoka A; Kametani F
    Biochem Biophys Res Commun; 2009 Feb; 380(1):111-4. PubMed ID: 19167357
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition.
    Oikawa N; Fabiano M; Müller UC; Walter J
    Biochem Biophys Res Commun; 2021 Sep; 570():137-142. PubMed ID: 34280617
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease.
    Li L; Zhang S; Zhang X; Li T; Tang Y; Liu H; Yang W; Le W
    Curr Alzheimer Res; 2013 May; 10(4):433-41. PubMed ID: 23305067
    [TBL] [Abstract][Full Text] [Related]  

  • 14. β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer's disease.
    Deng M; Huang L; Zhong X
    Mol Med Rep; 2020 May; 21(5):2095-2102. PubMed ID: 32186763
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Measuring APP carboxy-terminal fragments.
    Esposito LA
    Methods Mol Biol; 2011; 670():71-84. PubMed ID: 20967584
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides.
    Zhang Q; Yang G; Li W; Fan Z; Sun A; Luo J; Ke ZJ
    Neurobiol Aging; 2011 Jan; 32(1):42-53. PubMed ID: 19233513
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
    Nunan J; Shearman MS; Checler F; Cappai R; Evin G; Beyreuther K; Masters CL; Small DH
    Eur J Biochem; 2001 Oct; 268(20):5329-36. PubMed ID: 11606195
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
    Pinnix I; Musunuru U; Tun H; Sridharan A; Golde T; Eckman C; Ziani-Cherif C; Onstead L; Sambamurti K
    J Biol Chem; 2001 Jan; 276(1):481-7. PubMed ID: 11035007
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.