BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 21370283)

  • 1. The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.
    Stiborová M; Mareš J; Frei E; Arlt VM; Martínek V; Schmeiser HH
    Environ Mol Mutagen; 2011 Jul; 52(6):448-59. PubMed ID: 21370283
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
    Martinek V; Kubickova B; Arlt VM; Frei E; Schmeiser HH; Hudecek J; Stiborova M
    Neuro Endocrinol Lett; 2011; 32 Suppl 1():57-70. PubMed ID: 22167209
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.
    Stiborová M; Frei E; Sopko B; Sopková K; Marková V; Lanková M; Kumstýrová T; Wiessler M; Schmeiser HH
    Carcinogenesis; 2003 Oct; 24(10):1695-703. PubMed ID: 12869422
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
    Arlt VM; Stiborova M; Henderson CJ; Osborne MR; Bieler CA; Frei E; Martinek V; Sopko B; Wolf CR; Schmeiser HH; Phillips DH
    Cancer Res; 2005 Apr; 65(7):2644-52. PubMed ID: 15805261
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.
    Stiborová M; Frei E; Schmeiser HH; Arlt VM; Martínek V
    Int J Mol Sci; 2014 Jun; 15(6):10271-95. PubMed ID: 24918288
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.
    Milichovský J; Bárta F; Schmeiser HH; Arlt VM; Frei E; Stiborová M; Martínek V
    Int J Mol Sci; 2016 Feb; 17(2):213. PubMed ID: 26861298
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models.
    Bastek H; Zubel T; Stemmer K; Mangerich A; Beneke S; Dietrich DR
    Toxicology; 2019 May; 420():29-38. PubMed ID: 30940547
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.
    Stiborova M; Frei E; Arlt VM; Schmeiser HH
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2009 Mar; 153(1):5-11. PubMed ID: 19365519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.
    Jerabek P; Martinek V; Stiborova M
    Neuro Endocrinol Lett; 2012; 33 Suppl 3():25-32. PubMed ID: 23353840
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.
    Stiborová M; Sopko B; Hodek P; Frei E; Schmeiser HH; Hudecek J
    Cancer Lett; 2005 Nov; 229(2):193-204. PubMed ID: 16125300
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.
    Stiborova M; Mares J; Levova K; Pavlickova J; Barta F; Hodek P; Frei E; Schmeiser HH
    Neuro Endocrinol Lett; 2011; 32 Suppl 1():121-30. PubMed ID: 22167220
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
    Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M
    Toxicol Appl Pharmacol; 2012 Dec; 265(3):360-7. PubMed ID: 22982977
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats.
    Bárta F; Dedíková A; Bebová M; Dušková Š; Mráz J; Schmeiser HH; Arlt VM; Hodek P; Stiborová M
    Int J Mol Sci; 2021 Sep; 22(19):. PubMed ID: 34638820
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.
    Bárta F; Levová K; Frei E; Schmeiser HH; Arlt VM; Stiborová M
    Mutat Res Genet Toxicol Environ Mutagen; 2014 Jul; 768():1-7. PubMed ID: 24769487
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
    Stiborová M; Frei E; Hodek P; Wiessler M; Schmeiser HH
    Int J Cancer; 2005 Jan; 113(2):189-97. PubMed ID: 15386410
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.
    Stiborová M; Levová K; Bárta F; Šulc M; Frei E; Arlt VM; Schmeiser HH
    Mutagenesis; 2014 May; 29(3):189-200. PubMed ID: 24598128
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
    Levová K; Moserová M; Kotrbová V; Sulc M; Henderson CJ; Wolf CR; Phillips DH; Frei E; Schmeiser HH; Mares J; Arlt VM; Stiborová M
    Toxicol Sci; 2011 May; 121(1):43-56. PubMed ID: 21362632
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.
    Stiborová M; Martínek V; Frei E; Arlt VM; Schmeiser HH
    Curr Drug Metab; 2013 Jul; 14(6):695-705. PubMed ID: 23701164
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.
    Arlt VM; Meinl W; Florian S; Nagy E; Barta F; Thomann M; Mrizova I; Krais AM; Liu M; Richards M; Mirza A; Kopka K; Phillips DH; Glatt H; Stiborova M; Schmeiser HH
    Arch Toxicol; 2017 Apr; 91(4):1957-1975. PubMed ID: 27557898
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo.
    Stiborova M; Levova K; Barta F; Dracinska H; Sulc M; Hodek P; Frei E; Arlt VM; Schmeiser HH
    Neuro Endocrinol Lett; 2014; 35 Suppl 2():123-32. PubMed ID: 25638376
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.