290 related articles for article (PubMed ID: 21370850)
1. Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.
Vyazmensky M; Steinmetz A; Meyer D; Golbik R; Barak Z; Tittmann K; Chipman DM
Biochemistry; 2011 Apr; 50(15):3250-60. PubMed ID: 21370850
[TBL] [Abstract][Full Text] [Related]
2. Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.
Belenky I; Steinmetz A; Vyazmensky M; Barak Z; Tittmann K; Chipman DM
FEBS J; 2012 Jun; 279(11):1967-79. PubMed ID: 22443469
[TBL] [Abstract][Full Text] [Related]
3. Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.
Steinmetz A; Vyazmensky M; Meyer D; Barak ZE; Golbik R; Chipman DM; Tittmann K
Biochemistry; 2010 Jun; 49(25):5188-99. PubMed ID: 20504042
[TBL] [Abstract][Full Text] [Related]
4. The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR.
Tittmann K; Vyazmensky M; Hübner G; Barak Z; Chipman DM
Proc Natl Acad Sci U S A; 2005 Jan; 102(3):553-8. PubMed ID: 15640355
[TBL] [Abstract][Full Text] [Related]
5. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.
Bar-Ilan A; Balan V; Tittmann K; Golbik R; Vyazmensky M; Hübner G; Barak Z; Chipman DM
Biochemistry; 2001 Oct; 40(39):11946-54. PubMed ID: 11570896
[TBL] [Abstract][Full Text] [Related]
6. Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.
Engel S; Vyazmensky M; Vinogradov M; Berkovich D; Bar-Ilan A; Qimron U; Rosiansky Y; Barak Z; Chipman DM
J Biol Chem; 2004 Jun; 279(23):24803-12. PubMed ID: 15044456
[TBL] [Abstract][Full Text] [Related]
7. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis.
Ibdah M; Bar-Ilan A; Livnah O; Schloss JV; Barak Z; Chipman DM
Biochemistry; 1996 Dec; 35(50):16282-91. PubMed ID: 8973202
[TBL] [Abstract][Full Text] [Related]
8. Computational study on the carboligation reaction of acetohidroxyacid synthase: new approach on the role of the HEThDP- intermediate.
Jaña G; Jiménez V; Villà-Freixa J; Prat-Resina X; Delgado E; Alderete J
Proteins; 2010 May; 78(7):1774-88. PubMed ID: 20225259
[TBL] [Abstract][Full Text] [Related]
9. Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
Tittmann K; Schröder K; Golbik R; McCourt J; Kaplun A; Duggleby RG; Barak Z; Chipman DM; Hübner G
Biochemistry; 2004 Jul; 43(27):8652-61. PubMed ID: 15236573
[TBL] [Abstract][Full Text] [Related]
10. Structural and functional evaluation of three well-conserved serine residues in tobacco acetohydroxyacid synthase.
Yoon MY; Gedi V; Kim J; Park Y; Kim DE; Park EH; Choi JD
Biochimie; 2010 Jan; 92(1):65-70. PubMed ID: 19825392
[TBL] [Abstract][Full Text] [Related]
11. Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates.
Schütz A; Golbik R; König S; Hübner G; Tittmann K
Biochemistry; 2005 Apr; 44(16):6164-79. PubMed ID: 15835904
[TBL] [Abstract][Full Text] [Related]
12. Computational determination of fundamental pathway and activation barriers for acetohydroxyacid synthase-catalyzed condensation reactions of alpha-keto acids.
Xiong Y; Liu J; Yang GF; Zhan CG
J Comput Chem; 2010 Jun; 31(8):1592-602. PubMed ID: 19554557
[TBL] [Abstract][Full Text] [Related]
13. Catalytic Role of Gln202 in the Carboligation Reaction Mechanism of Yeast AHAS: A QM/MM Study.
Mendoza F; Medina FE; Jiménez VA; Jaña GA
J Chem Inf Model; 2020 Feb; 60(2):915-922. PubMed ID: 31841000
[TBL] [Abstract][Full Text] [Related]
14. Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.
Baig IA; Gedi V; Lee SC; Koh SH; Yoon MY
Enzyme Microb Technol; 2013 Sep; 53(4):243-9. PubMed ID: 23931689
[TBL] [Abstract][Full Text] [Related]
15. Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases.
Chipman D; Barak Z; Schloss JV
Biochim Biophys Acta; 1998 Jun; 1385(2):401-19. PubMed ID: 9655946
[TBL] [Abstract][Full Text] [Related]
16. Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues.
Jiang M; Chen X; Wu XH; Chen M; Wu YD; Guo Z
Biochemistry; 2009 Jul; 48(29):6921-31. PubMed ID: 19545176
[TBL] [Abstract][Full Text] [Related]
17. Structural and kinetic studies on native intermediates and an intermediate analogue in benzoylformate decarboxylase reveal a least motion mechanism with an unprecedented short-lived predecarboxylation intermediate.
Bruning M; Berheide M; Meyer D; Golbik R; Bartunik H; Liese A; Tittmann K
Biochemistry; 2009 Apr; 48(15):3258-68. PubMed ID: 19182954
[TBL] [Abstract][Full Text] [Related]
18. Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors.
Choi KJ; Noh KM; Kim DE; Ha BH; Kim EE; Yoon MY
Arch Biochem Biophys; 2007 Oct; 466(1):24-30. PubMed ID: 17718999
[TBL] [Abstract][Full Text] [Related]
19. Roles of three well-conserved arginine residues in mediating the catalytic activity of tobacco acetohydroxy acid synthase.
Le DT; Yoon MY; Kim YT; Choi JD
J Biochem; 2005 Jul; 138(1):35-40. PubMed ID: 16046446
[TBL] [Abstract][Full Text] [Related]
20. Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD.
Li C; Li JJ; Montgomery MG; Wood SP; Bugg TD
Biochemistry; 2006 Oct; 45(41):12470-9. PubMed ID: 17029402
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]