BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

376 related articles for article (PubMed ID: 21383990)

  • 1. Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.
    FitzGerald J; Moureau S; Drogaris P; O'Connell E; Abshiru N; Verreault A; Thibault P; Grenon M; Lowndes NF
    PLoS One; 2011 Feb; 6(2):e14714. PubMed ID: 21383990
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.
    Wakeman TP; Wang Q; Feng J; Wang XF
    EMBO J; 2012 May; 31(9):2169-81. PubMed ID: 22373577
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
    Hartlerode AJ; Guan Y; Rajendran A; Ura K; Schotta G; Xie A; Shah JV; Scully R
    PLoS One; 2012; 7(11):e49211. PubMed ID: 23209566
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
    Jones B; Su H; Bhat A; Lei H; Bajko J; Hevi S; Baltus GA; Kadam S; Zhai H; Valdez R; Gonzalo S; Zhang Y; Li E; Chen T
    PLoS Genet; 2008 Sep; 4(9):e1000190. PubMed ID: 18787701
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.
    Kim W; Choi M; Kim JE
    Cell Cycle; 2014; 13(5):726-38. PubMed ID: 24526115
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
    Huyen Y; Zgheib O; Ditullio RA; Gorgoulis VG; Zacharatos P; Petty TJ; Sheston EA; Mellert HS; Stavridi ES; Halazonetis TD
    Nature; 2004 Nov; 432(7015):406-11. PubMed ID: 15525939
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
    Kari V; Raul SK; Henck JM; Kitz J; Kramer F; Kosinsky RL; Übelmesser N; Mansour WY; Eggert J; Spitzner M; Najafova Z; Bastians H; Grade M; Gaedcke J; Wegwitz F; Johnsen SA
    Clin Epigenetics; 2019 Jan; 11(1):4. PubMed ID: 30616689
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
    Steger DJ; Lefterova MI; Ying L; Stonestrom AJ; Schupp M; Zhuo D; Vakoc AL; Kim JE; Chen J; Lazar MA; Blobel GA; Vakoc CR
    Mol Cell Biol; 2008 Apr; 28(8):2825-39. PubMed ID: 18285465
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.
    Pei H; Zhang L; Luo K; Qin Y; Chesi M; Fei F; Bergsagel PL; Wang L; You Z; Lou Z
    Nature; 2011 Feb; 470(7332):124-8. PubMed ID: 21293379
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair.
    Hsiao KY; Mizzen CA
    J Mol Cell Biol; 2013 Jun; 5(3):157-65. PubMed ID: 23329852
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
    Deshpande AJ; Chen L; Fazio M; Sinha AU; Bernt KM; Banka D; Dias S; Chang J; Olhava EJ; Daigle SR; Richon VM; Pollock RM; Armstrong SA
    Blood; 2013 Mar; 121(13):2533-41. PubMed ID: 23361907
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation.
    Kim W; Kim R; Park G; Park JW; Kim JE
    J Biol Chem; 2012 Feb; 287(8):5588-99. PubMed ID: 22190683
    [TBL] [Abstract][Full Text] [Related]  

  • 13. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.
    Ho LL; Sinha A; Verzi M; Bernt KM; Armstrong SA; Shivdasani RA
    Mol Cell Biol; 2013 May; 33(9):1735-45. PubMed ID: 23428873
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
    Fradet-Turcotte A; Canny MD; Escribano-Díaz C; Orthwein A; Leung CC; Huang H; Landry MC; Kitevski-LeBlanc J; Noordermeer SM; Sicheri F; Durocher D
    Nature; 2013 Jul; 499(7456):50-4. PubMed ID: 23760478
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
    Chen S; Yang Z; Wilkinson AW; Deshpande AJ; Sidoli S; Krajewski K; Strahl BD; Garcia BA; Armstrong SA; Patel DJ; Gozani O
    Mol Cell; 2015 Oct; 60(2):319-27. PubMed ID: 26439302
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy.
    Mao Y; Sun Y; Wu Z; Zheng J; Zhang J; Zeng J; Lee C; Kim JK
    Cell Death Dis; 2021 Dec; 12(12):1141. PubMed ID: 34887387
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation.
    Cao K; Ugarenko M; Ozark PA; Wang J; Marshall SA; Rendleman EJ; Liang K; Wang L; Zou L; Smith ER; Yue F; Shilatifard A
    Proc Natl Acad Sci U S A; 2020 Nov; 117(44):27365-27373. PubMed ID: 33077595
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
    Lin H; Cossu IG; Leu NA; Deshpande AJ; Bernt KM; Luo M; Wang PJ
    Development; 2023 May; 150(9):. PubMed ID: 37082953
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PTIP regulates 53BP1 and SMC1 at the DNA damage sites.
    Wu J; Prindle MJ; Dressler GR; Yu X
    J Biol Chem; 2009 Jul; 284(27):18078-84. PubMed ID: 19414588
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
    Rau RE; Rodriguez BA; Luo M; Jeong M; Rosen A; Rogers JH; Campbell CT; Daigle SR; Deng L; Song Y; Sweet S; Chevassut T; Andreeff M; Kornblau SM; Li W; Goodell MA
    Blood; 2016 Aug; 128(7):971-81. PubMed ID: 27335278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.