154 related articles for article (PubMed ID: 21384134)
1. DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.
Hartley JA; Hamaguchi A; Suggitt M; Gregson SJ; Thurston DE; Howard PW
Invest New Drugs; 2012 Jun; 30(3):950-8. PubMed ID: 21384134
[TBL] [Abstract][Full Text] [Related]
2. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
[TBL] [Abstract][Full Text] [Related]
3. SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.
Hartley JA; Hamaguchi A; Coffils M; Martin CR; Suggitt M; Chen Z; Gregson SJ; Masterson LA; Tiberghien AC; Hartley JM; Pepper C; Lin TT; Fegan C; Thurston DE; Howard PW
Cancer Res; 2010 Sep; 70(17):6849-58. PubMed ID: 20660714
[TBL] [Abstract][Full Text] [Related]
4. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.
Mellinas-Gomez M; Spanswick VJ; Paredes-Moscosso SR; Robson M; Pedley RB; Thurston DE; Baines SJ; Stell A; Hartley JA
BMC Vet Res; 2015 Aug; 11():215. PubMed ID: 26282406
[TBL] [Abstract][Full Text] [Related]
5. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Alley MC; Hollingshead MG; Pacula-Cox CM; Waud WR; Hartley JA; Howard PW; Gregson SJ; Thurston DE; Sausville EA
Cancer Res; 2004 Sep; 64(18):6700-6. PubMed ID: 15374987
[TBL] [Abstract][Full Text] [Related]
6. The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.
Clingen PH; De Silva IU; McHugh PJ; Ghadessy FJ; Tilby MJ; Thurston DE; Hartley JA
Nucleic Acids Res; 2005; 33(10):3283-91. PubMed ID: 15944449
[TBL] [Abstract][Full Text] [Related]
7. Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Martin C; Ellis T; McGurk CJ; Jenkins TC; Hartley JA; Waring MJ; Thurston DE
Biochemistry; 2005 Mar; 44(11):4135-47. PubMed ID: 15766241
[TBL] [Abstract][Full Text] [Related]
8. Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
Wilkinson GP; Taylor JP; Shnyder S; Cooper P; Howard PW; Thurston DE; Jenkins TC; Loadman PM
Invest New Drugs; 2004 Aug; 22(3):231-40. PubMed ID: 15122070
[TBL] [Abstract][Full Text] [Related]
9. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Gregson SJ; Howard PW; Hartley JA; Brooks NA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
J Med Chem; 2001 Mar; 44(5):737-48. PubMed ID: 11262084
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Wilson SC; Howard PW; Forrow SM; Hartley JA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
J Med Chem; 1999 Oct; 42(20):4028-41. PubMed ID: 10514273
[TBL] [Abstract][Full Text] [Related]
12. The development of pyrrolobenzodiazepines as antitumour agents.
Hartley JA
Expert Opin Investig Drugs; 2011 Jun; 20(6):733-44. PubMed ID: 21457108
[TBL] [Abstract][Full Text] [Related]
13. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.
Hartley JA; Flynn MJ; Bingham JP; Corbett S; Reinert H; Tiberghien A; Masterson LA; Antonow D; Adams L; Chowdhury S; Williams DG; Mao S; Harper J; Havenith CEG; Zammarchi F; Chivers S; van Berkel PH; Howard PW
Sci Rep; 2018 Jul; 8(1):10479. PubMed ID: 29992976
[TBL] [Abstract][Full Text] [Related]
14. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Mantaj J; Jackson PJ; Rahman KM; Thurston DE
Angew Chem Int Ed Engl; 2017 Jan; 56(2):462-488. PubMed ID: 27862776
[TBL] [Abstract][Full Text] [Related]
15. Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Tercel M; Stribbling SM; Sheppard H; Siim BG; Wu K; Pullen SM; Botting KJ; Wilson WR; Denny WA
J Med Chem; 2003 May; 46(11):2132-51. PubMed ID: 12747786
[TBL] [Abstract][Full Text] [Related]
16. The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
Rahman KM; Thompson AS; James CH; Narayanaswamy M; Thurston DE
J Am Chem Soc; 2009 Sep; 131(38):13756-66. PubMed ID: 19725510
[TBL] [Abstract][Full Text] [Related]
17. The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
Pepper CJ; Hambly RM; Fegan CD; Delavault P; Thurston DE
Cancer Res; 2004 Sep; 64(18):6750-5. PubMed ID: 15374993
[TBL] [Abstract][Full Text] [Related]
18. Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats.
Reid JM; Buhrow SA; Kuffel MJ; Jia L; Spanswick VJ; Hartley JA; Thurston DE; Tomaszewski JE; Ames MM
Cancer Chemother Pharmacol; 2011 Sep; 68(3):777-86. PubMed ID: 21188379
[TBL] [Abstract][Full Text] [Related]
19. Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
Rahman KM; James CH; Thurston DE
Nucleic Acids Res; 2011 Jul; 39(13):5800-12. PubMed ID: 21427082
[TBL] [Abstract][Full Text] [Related]
20. Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136.
Hopton SR; Thompson AS
Biochemistry; 2011 May; 50(21):4720-32. PubMed ID: 21488658
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]