BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 21386980)

  • 1. Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
    Valbuena A; Castro-Obregón S; Lazo PA
    PLoS One; 2011 Feb; 6(2):e17320. PubMed ID: 21386980
    [TBL] [Abstract][Full Text] [Related]  

  • 2. p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.
    Valbuena A; Vega FM; Blanco S; Lazo PA
    Mol Cell Biol; 2006 Jul; 26(13):4782-93. PubMed ID: 16782868
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.
    Park CH; Choi BH; Jeong MW; Kim S; Kim W; Song YS; Kim KT
    Mol Biol Cell; 2011 Apr; 22(8):1398-408. PubMed ID: 21346188
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells.
    Yokobori K; Miyauchi Y; Williams JG; Negishi M
    Biosci Rep; 2020 Apr; 40(4):. PubMed ID: 32266931
    [TBL] [Abstract][Full Text] [Related]  

  • 5. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
    López-Sánchez I; Valbuena A; Vázquez-Cedeira M; Khadake J; Sanz-García M; Carrillo-Jiménez A; Lazo PA
    FEBS Lett; 2014 Mar; 588(5):692-700. PubMed ID: 24492002
    [TBL] [Abstract][Full Text] [Related]  

  • 6. p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
    Vega FM; Sevilla A; Lazo PA
    Mol Cell Biol; 2004 Dec; 24(23):10366-80. PubMed ID: 15542844
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells.
    Cui L; Song Z; Liang B; Jia L; Ma S; Liu X
    Oncol Rep; 2016 Jun; 35(6):3639-47. PubMed ID: 27109777
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.
    Valbuena A; Blanco S; Vega FM; Lazo PA
    PLoS One; 2008 Jul; 3(7):e2649. PubMed ID: 18612383
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.
    Valbuena A; Suárez-Gauthier A; López-Rios F; López-Encuentra A; Blanco S; Fernández PL; Sánchez-Céspedes M; Lazo PA
    Lung Cancer; 2007 Dec; 58(3):303-9. PubMed ID: 17689819
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy.
    Lorin S; Pierron G; Ryan KM; Codogno P; Djavaheri-Mergny M
    Autophagy; 2010 Jan; 6(1):153-4. PubMed ID: 19949306
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?
    Choudhury S; Kolukula VK; Preet A; Albanese C; Avantaggiati ML
    Cell Cycle; 2013 Apr; 12(7):1022-9. PubMed ID: 23466706
    [TBL] [Abstract][Full Text] [Related]  

  • 12. VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage.
    Monsalve DM; Campillo-Marcos I; Salzano M; Sanz-García M; Cantarero L; Lazo PA
    Biochim Biophys Acta; 2016 Apr; 1863(4):760-9. PubMed ID: 26869104
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.
    Campillo-Marcos I; Lazo PA
    J Exp Clin Cancer Res; 2019 May; 38(1):203. PubMed ID: 31101118
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.
    Lee HY; Oh SH
    Biochem Biophys Res Commun; 2021 Jan; 534():128-133. PubMed ID: 33321290
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response.
    Salzano M; Vázquez-Cedeira M; Sanz-García M; Valbuena A; Blanco S; Fernández IF; Lazo PA
    Oncotarget; 2014 Apr; 5(7):1770-8. PubMed ID: 24731990
    [TBL] [Abstract][Full Text] [Related]  

  • 16. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.
    Moumen A; Masterson P; O'Connor MJ; Jackson SP
    Cell; 2005 Dec; 123(6):1065-78. PubMed ID: 16360036
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
    Sanz-García M; Monsalve DM; Sevilla A; Lazo PA
    J Biol Chem; 2012 Jul; 287(28):23757-68. PubMed ID: 22621922
    [TBL] [Abstract][Full Text] [Related]  

  • 18. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions.
    Garufi A; Pistritto G; Baldari S; Toietta G; Cirone M; D'Orazi G
    J Exp Clin Cancer Res; 2017 Sep; 36(1):126. PubMed ID: 28893313
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.
    Lopez-Borges S; Lazo PA
    Oncogene; 2000 Jul; 19(32):3656-64. PubMed ID: 10951572
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.
    Valbuena A; López-Sánchez I; Lazo PA
    PLoS One; 2008 Feb; 3(2):e1642. PubMed ID: 18286197
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.