326 related articles for article (PubMed ID: 21389104)
1. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.
Yu Y; Suryo Rahmanto Y; Hawkins CL; Richardson DR
Mol Pharmacol; 2011 Jun; 79(6):921-31. PubMed ID: 21389104
[TBL] [Abstract][Full Text] [Related]
2. Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.
Chaston TB; Lovejoy DB; Watts RN; Richardson DR
Clin Cancer Res; 2003 Jan; 9(1):402-14. PubMed ID: 12538494
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
[TBL] [Abstract][Full Text] [Related]
4. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
[TBL] [Abstract][Full Text] [Related]
5. Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.
Jansson PJ; Sharpe PC; Bernhardt PV; Richardson DR
J Med Chem; 2010 Aug; 53(15):5759-69. PubMed ID: 20597487
[TBL] [Abstract][Full Text] [Related]
6. 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
Richardson DR; Kalinowski DS; Richardson V; Sharpe PC; Lovejoy DB; Islam M; Bernhardt PV
J Med Chem; 2009 Mar; 52(5):1459-70. PubMed ID: 19216562
[TBL] [Abstract][Full Text] [Related]
7. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
Opletalová V; Kalinowski DS; Vejsová M; Kunes J; Pour M; Jampílek J; Buchta V; Richardson DR
Chem Res Toxicol; 2008 Sep; 21(9):1878-89. PubMed ID: 18698850
[TBL] [Abstract][Full Text] [Related]
8. Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
Stefani C; Jansson PJ; Gutierrez E; Bernhardt PV; Richardson DR; Kalinowski DS
J Med Chem; 2013 Jan; 56(1):357-70. PubMed ID: 23276209
[TBL] [Abstract][Full Text] [Related]
9. The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress.
Myers JM; Antholine WE; Zielonka J; Myers CR
Toxicol Lett; 2011 Mar; 201(2):130-6. PubMed ID: 21195754
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
J Inorg Biochem; 2014 Dec; 141():43-54. PubMed ID: 25217717
[TBL] [Abstract][Full Text] [Related]
11. Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
Yu Y; Suryo Rahmanto Y; Richardson DR
Br J Pharmacol; 2012 Jan; 165(1):148-66. PubMed ID: 21658021
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy.
Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
Bioorg Med Chem Lett; 2013 Feb; 23(4):967-74. PubMed ID: 23312948
[TBL] [Abstract][Full Text] [Related]
13. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.
Whitnall M; Howard J; Ponka P; Richardson DR
Proc Natl Acad Sci U S A; 2006 Oct; 103(40):14901-6. PubMed ID: 17003122
[TBL] [Abstract][Full Text] [Related]
14. Effects of the ferrous chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the kinetics of reduction of CDP by ribonucleotide reductase of the Novikoff tumor.
Preidecker PJ; Agrawal KC; Sartorelli AC; Moore EC
Mol Pharmacol; 1980 Nov; 18(3):507-12. PubMed ID: 7007866
[No Abstract] [Full Text] [Related]
15. Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer.
Kovacevic Z; Chikhani S; Lovejoy DB; Richardson DR
Mol Pharmacol; 2011 Oct; 80(4):598-609. PubMed ID: 21719465
[TBL] [Abstract][Full Text] [Related]
16. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase.
Zhu L; Zhou B; Chen X; Jiang H; Shao J; Yen Y
Biochem Pharmacol; 2009 Nov; 78(9):1178-85. PubMed ID: 19576866
[TBL] [Abstract][Full Text] [Related]
17. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.
Debebe Z; Ammosova T; Breuer D; Lovejoy DB; Kalinowski DS; Kumar K; Jerebtsova M; Ray P; Kashanchi F; Gordeuk VR; Richardson DR; Nekhai S
Mol Pharmacol; 2011 Jan; 79(1):185-96. PubMed ID: 20956357
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
J Med Chem; 2007 Nov; 50(24):6212-25. PubMed ID: 17963372
[TBL] [Abstract][Full Text] [Related]
19. Trypanotoxic activity of thiosemicarbazone iron chelators.
Ellis S; Sexton DW; Steverding D
Exp Parasitol; 2015 Mar; 150():7-12. PubMed ID: 25595343
[TBL] [Abstract][Full Text] [Related]
20. Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.
Lovejoy DB; Richardson DR
Blood; 2002 Jul; 100(2):666-76. PubMed ID: 12091363
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
