These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 21391686)

  • 1. Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
    Zeglis BM; Divilov V; Lewis JS
    J Med Chem; 2011 Apr; 54(7):2391-8. PubMed ID: 21391686
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα.
    Wilson JT; Jiang X; McGill BC; Lisic EC; Deweese JE
    Chem Res Toxicol; 2016 Apr; 29(4):649-58. PubMed ID: 26982206
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ.
    Keck JM; Conner JD; Wilson JT; Jiang X; Lisic EC; Deweese JE
    Chem Res Toxicol; 2019 Oct; 32(10):2135-2143. PubMed ID: 31512855
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Copper(II) complexes with highly water-soluble L- and D-proline-thiosemicarbazone conjugates as potential inhibitors of Topoisomerase IIα.
    Bacher F; Enyedy É; Nagy NV; Rockenbauer A; Bognár GM; Trondl R; Novak MS; Klapproth E; Kiss T; Arion VB
    Inorg Chem; 2013 Aug; 52(15):8895-908. PubMed ID: 23829568
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and Metal Ion Effects on Human Topoisomerase IIα Inhibition by α-(N)-Heterocyclic Thiosemicarbazones.
    Morris WH; Ngo L; Wilson JT; Medawala W; Brown AR; Conner JD; Fabunmi F; Cashman DJ; Lisic EC; Yu T; Deweese JE; Jiang X
    Chem Res Toxicol; 2019 Jan; 32(1):90-99. PubMed ID: 30484632
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quinoline-2-carboxaldehyde thiosemicarbazones and their Cu(II) and Ni(II) complexes as topoisomerase IIa inhibitors.
    Bisceglie F; Musiari A; Pinelli S; Alinovi R; Menozzi I; Polverini E; Tarasconi P; Tavone M; Pelosi G
    J Inorg Biochem; 2015 Nov; 152():10-9. PubMed ID: 26335598
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors.
    Han X; Zhong Y; Zhou G; Qi H; Li S; Ding Q; Liu Z; Song Y; Qiao X
    Bioorg Med Chem; 2017 Jun; 25(12):3116-3126. PubMed ID: 28462840
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies.
    Arjmand F; Yousuf I; Hadda Tb; Toupet L
    Eur J Med Chem; 2014 Jun; 81():76-88. PubMed ID: 24826817
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
    Huang H; Chen Q; Ku X; Meng L; Lin L; Wang X; Zhu C; Wang Y; Chen Z; Li M; Jiang H; Chen K; Ding J; Liu H
    J Med Chem; 2010 Apr; 53(8):3048-64. PubMed ID: 20353152
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor.
    Kadayat TM; Park C; Jun KY; Thapa Magar TB; Bist G; Yoo HY; Kwon Y; Lee ES
    Eur J Med Chem; 2015 Jan; 90():302-14. PubMed ID: 25437617
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and structure of [(η(6)-p-cymene)Ru(2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl; biological evaluation, topoisomerase II inhibition and reaction with DNA and human serum albumin.
    Beckford F; Thessing J; Woods J; Didion J; Gerasimchuk N; Gonzalez-Sarrias A; Seeram NP
    Metallomics; 2011 May; 3(5):491-502. PubMed ID: 21347491
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.
    de Oliveira JF; Lima TS; Vendramini-Costa DB; de Lacerda Pedrosa SCB; Lafayette EA; da Silva RMF; de Almeida SMV; de Moura RO; Ruiz ALTG; de Carvalho JE; de Lima MDCA
    Eur J Med Chem; 2017 Aug; 136():305-314. PubMed ID: 28505535
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition.
    Ribeiro AG; Almeida SMV; de Oliveira JF; Souza TRCL; Santos KLD; Albuquerque APB; Nogueira MCBL; Carvalho Junior LB; Moura RO; da Silva AC; Pereira VRA; Castro MCAB; Lima MDCA
    Eur J Med Chem; 2019 Nov; 182():111592. PubMed ID: 31421632
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.
    Yalowich JC; Wu X; Zhang R; Kanagasabai R; Hornbaker M; Hasinoff BB
    Biochem Pharmacol; 2012 Jul; 84(1):52-8. PubMed ID: 22503743
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.
    Park SE; Chang IH; Jun KY; Lee E; Lee ES; Na Y; Kwon Y
    Eur J Med Chem; 2013 Nov; 69():139-45. PubMed ID: 24013413
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological activity of ferrocenyl indeno[1,2-c]isoquinolines as topoisomerase II inhibitors.
    Wambang N; Schifano-Faux N; Aillerie A; Baldeyrou B; Jacquet C; Bal-Mahieu C; Bousquet T; Pellegrini S; Ndifon PT; Meignan S; Goossens JF; Lansiaux A; Pélinski L
    Bioorg Med Chem; 2016 Feb; 24(4):651-60. PubMed ID: 26740155
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties.
    Palluotto F; Sosic A; Pinato O; Zoidis G; Catto M; Sissi C; Gatto B; Carotti A
    Eur J Med Chem; 2016 Nov; 123():704-717. PubMed ID: 27521587
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.
    Kunwar S; Hwang SY; Katila P; Man Kadayat T; Jung AR; Kwon Y; Lee ES
    Bioorg Med Chem Lett; 2022 Mar; 60():128606. PubMed ID: 35123005
    [TBL] [Abstract][Full Text] [Related]  

  • 19. L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity.
    Milunovic MN; Enyedy É; Nagy NV; Kiss T; Trondl R; Jakupec MA; Keppler BK; Krachler R; Novitchi G; Arion VB
    Inorg Chem; 2012 Sep; 51(17):9309-21. PubMed ID: 22889304
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Strong effect of copper(II) coordination on antiproliferative activity of thiosemicarbazone-piperazine and thiosemicarbazone-morpholine hybrids.
    Bacher F; Dömötör O; Chugunova A; Nagy NV; Filipović L; Radulović S; Enyedy ÉA; Arion VB
    Dalton Trans; 2015 May; 44(19):9071-90. PubMed ID: 25896351
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.