BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 21398519)

  • 1. Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.
    Dmitriev OY; Bhattacharjee A; Nokhrin S; Uhlemann EM; Lutsenko S
    J Biol Chem; 2011 May; 286(18):16355-62. PubMed ID: 21398519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F.
    Morgan CT; Tsivkovskii R; Kosinsky YA; Efremov RG; Lutsenko S
    J Biol Chem; 2004 Aug; 279(35):36363-71. PubMed ID: 15205462
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The role of the invariant His-1069 in folding and function of the Wilson's disease protein, the human copper-transporting ATPase ATP7B.
    Tsivkovskii R; Efremov RG; Lutsenko S
    J Biol Chem; 2003 Apr; 278(15):13302-8. PubMed ID: 12551905
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system.
    Hsi G; Cullen LM; Macintyre G; Chen MM; Glerum DM; Cox DW
    Hum Mutat; 2008 Apr; 29(4):491-501. PubMed ID: 18203200
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular events initiating exit of a copper-transporting ATPase ATP7B from the trans-Golgi network.
    Hasan NM; Gupta A; Polishchuk E; Yu CH; Polishchuk R; Dmitriev OY; Lutsenko S
    J Biol Chem; 2012 Oct; 287(43):36041-50. PubMed ID: 22898812
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Stability and ATP binding of the nucleotide-binding domain of the Wilson disease protein: effect of the common H1069Q mutation.
    Rodriguez-Granillo A; Sedlak E; Wittung-Stafshede P
    J Mol Biol; 2008 Nov; 383(5):1097-111. PubMed ID: 18692069
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solution structure of the N-domain of Wilson disease protein: distinct nucleotide-binding environment and effects of disease mutations.
    Dmitriev O; Tsivkovskii R; Abildgaard F; Morgan CT; Markley JL; Lutsenko S
    Proc Natl Acad Sci U S A; 2006 Apr; 103(14):5302-7. PubMed ID: 16567646
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties.
    Roy S; McCann CJ; Ralle M; Ray K; Ray J; Lutsenko S; Jayakanthan S
    Sci Rep; 2020 Aug; 10(1):13487. PubMed ID: 32778786
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Diverse functional properties of Wilson disease ATP7B variants.
    Huster D; Kühne A; Bhattacharjee A; Raines L; Jantsch V; Noe J; Schirrmeister W; Sommerer I; Sabri O; Berr F; Mössner J; Stieger B; Caca K; Lutsenko S
    Gastroenterology; 2012 Apr; 142(4):947-956.e5. PubMed ID: 22240481
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.
    Chesi G; Hegde RN; Iacobacci S; Concilli M; Parashuraman S; Festa BP; Polishchuk EV; Di Tullio G; Carissimo A; Montefusco S; Canetti D; Monti M; Amoresano A; Pucci P; van de Sluis B; Lutsenko S; Luini A; Polishchuk RS
    Hepatology; 2016 Jun; 63(6):1842-59. PubMed ID: 26660341
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B.
    Braiterman LT; Murthy A; Jayakanthan S; Nyasae L; Tzeng E; Gromadzka G; Woolf TB; Lutsenko S; Hubbard AL
    Proc Natl Acad Sci U S A; 2014 Apr; 111(14):E1364-73. PubMed ID: 24706876
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin.
    van den Berghe PV; Stapelbroek JM; Krieger E; de Bie P; van de Graaf SF; de Groot RE; van Beurden E; Spijker E; Houwen RH; Berger R; Klomp LW
    Hepatology; 2009 Dec; 50(6):1783-95. PubMed ID: 19937698
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.
    Braiterman L; Nyasae L; Leves F; Hubbard AL
    Am J Physiol Gastrointest Liver Physiol; 2011 Jul; 301(1):G69-81. PubMed ID: 21454443
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.
    de Bie P; van de Sluis B; Burstein E; van de Berghe PV; Muller P; Berger R; Gitlin JD; Wijmenga C; Klomp LW
    Gastroenterology; 2007 Oct; 133(4):1316-26. PubMed ID: 17919502
    [TBL] [Abstract][Full Text] [Related]  

  • 15. p.H1069Q mutation in ATP7B and biochemical parameters of copper metabolism and clinical manifestation of Wilson's disease.
    Gromadzka G; Schmidt HH; Genschel J; Bochow B; Rodo M; Tarnacka B; Litwin T; Chabik G; Członkowska A
    Mov Disord; 2006 Feb; 21(2):245-8. PubMed ID: 16211609
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism.
    Schushan M; Bhattacharjee A; Ben-Tal N; Lutsenko S
    Metallomics; 2012 Jul; 4(7):669-78. PubMed ID: 22692182
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein.
    Gupta A; Bhattacharjee A; Dmitriev OY; Nokhrin S; Braiterman L; Hubbard AL; Lutsenko S
    Proc Natl Acad Sci U S A; 2011 Mar; 108(13):5390-5. PubMed ID: 21406592
    [TBL] [Abstract][Full Text] [Related]  

  • 18. From clinical and biochemical to molecular genetic diagnosis of Wilson disease in Latvia.
    Krumina A; Keiss J; Sondore V; Chernushenko A; Cernevska G; Zarina A; Micule I; Piekuse L; Kreile M; Lace B; Krumina Z; Rozentale B
    Genetika; 2008 Oct; 44(10):1379-84. PubMed ID: 19062534
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?
    Forbes JR; Cox DW
    Am J Hum Genet; 1998 Dec; 63(6):1663-74. PubMed ID: 9837819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B.
    Braiterman L; Nyasae L; Guo Y; Bustos R; Lutsenko S; Hubbard A
    Am J Physiol Gastrointest Liver Physiol; 2009 Feb; 296(2):G433-44. PubMed ID: 19033537
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.