176 related articles for article (PubMed ID: 21410186)
1. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Xue F; Fang J; Delker SL; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
J Med Chem; 2011 Apr; 54(7):2039-48. PubMed ID: 21410186
[TBL] [Abstract][Full Text] [Related]
2. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Delker SL; Xue F; Li H; Jamal J; Silverman RB; Poulos TL
Biochemistry; 2010 Dec; 49(51):10803-10. PubMed ID: 21138269
[TBL] [Abstract][Full Text] [Related]
3. 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
Kang S; Li H; Tang W; Martásek P; Roman LJ; Poulos TL; Silverman RB
J Med Chem; 2015 Jul; 58(14):5548-60. PubMed ID: 26120733
[TBL] [Abstract][Full Text] [Related]
4. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Vasu D; Li H; Hardy CD; Poulos TL; Silverman RB
Bioorg Med Chem; 2022 Sep; 69():116878. PubMed ID: 35772285
[TBL] [Abstract][Full Text] [Related]
5. Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Xue F; Fang J; Lewis WW; Martásek P; Roman LJ; Silverman RB
Bioorg Med Chem Lett; 2010 Jan; 20(2):554-7. PubMed ID: 19963381
[TBL] [Abstract][Full Text] [Related]
6. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Wang HY; Qin Y; Li H; Roman LJ; Martásek P; Poulos TL; Silverman RB
J Med Chem; 2016 May; 59(10):4913-25. PubMed ID: 27050842
[TBL] [Abstract][Full Text] [Related]
7. Structural basis for isoform-selective inhibition in nitric oxide synthase.
Poulos TL; Li H
Acc Chem Res; 2013 Feb; 46(2):390-8. PubMed ID: 23030042
[TBL] [Abstract][Full Text] [Related]
8. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
Do HT; Li H; Chreifi G; Poulos TL; Silverman RB
J Med Chem; 2019 Mar; 62(5):2690-2707. PubMed ID: 30802056
[TBL] [Abstract][Full Text] [Related]
9. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Jing Q; Li H; Fang J; Roman LJ; Martásek P; Poulos TL; Silverman RB
Bioorg Med Chem; 2013 Sep; 21(17):5323-31. PubMed ID: 23867386
[TBL] [Abstract][Full Text] [Related]
10. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
Ji H; Delker SL; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
J Med Chem; 2010 Nov; 53(21):7804-24. PubMed ID: 20958055
[TBL] [Abstract][Full Text] [Related]
11. Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.
Li H; Wang HY; Kang S; Silverman RB; Poulos TL
Biochemistry; 2016 Jul; 55(26):3702-7. PubMed ID: 27250740
[TBL] [Abstract][Full Text] [Related]
12. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
Igarashi J; Li H; Jamal J; Ji H; Fang J; Lawton GR; Silverman RB; Poulos TL
J Med Chem; 2009 Apr; 52(7):2060-6. PubMed ID: 19296678
[TBL] [Abstract][Full Text] [Related]
13. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Do HT; Wang HY; Li H; Chreifi G; Poulos TL; Silverman RB
J Med Chem; 2017 Nov; 60(22):9360-9375. PubMed ID: 29091437
[TBL] [Abstract][Full Text] [Related]
14. Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Xue F; Li H; Fang J; Roman LJ; Martásek P; Poulos TL; Silverman RB
Bioorg Med Chem Lett; 2010 Nov; 20(21):6258-61. PubMed ID: 20833542
[TBL] [Abstract][Full Text] [Related]
15. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Huang H; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
J Med Chem; 2013 Apr; 56(7):3024-32. PubMed ID: 23451760
[TBL] [Abstract][Full Text] [Related]
16. Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms.
Oliveira BL; Moreira IS; Fernandes PA; Ramos MJ; Santos I; Correia JD
J Mol Model; 2013 Apr; 19(4):1537-51. PubMed ID: 23263357
[TBL] [Abstract][Full Text] [Related]
17. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Jing Q; Li H; Chreifi G; Roman LJ; Martásek P; Poulos TL; Silverman RB
Bioorg Med Chem Lett; 2013 Oct; 23(20):5674-9. PubMed ID: 23993333
[TBL] [Abstract][Full Text] [Related]
18. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.
Cinelli MA; Li H; Chreifi G; Martásek P; Roman LJ; Poulos TL; Silverman RB
J Med Chem; 2014 Feb; 57(4):1513-30. PubMed ID: 24472039
[TBL] [Abstract][Full Text] [Related]
19. Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Lawton GR; Ralay Ranaivo H; Chico LK; Ji H; Xue F; Martásek P; Roman LJ; Watterson DM; Silverman RB
Bioorg Med Chem; 2009 Mar; 17(6):2371-80. PubMed ID: 19268602
[TBL] [Abstract][Full Text] [Related]
20. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Xue F; Huang J; Ji H; Fang J; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
Bioorg Med Chem; 2010 Sep; 18(17):6526-37. PubMed ID: 20673724
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
