238 related articles for article (PubMed ID: 21420302)
1. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.
Benelkebir H; Marie S; Hayden AL; Lyle J; Loadman PM; Crabb SJ; Packham G; Ganesan A
Bioorg Med Chem; 2011 Jun; 19(12):3650-8. PubMed ID: 21420302
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of c7-demethyl largazole analogues.
Chen F; Gao AH; Li J; Nan FJ
ChemMedChem; 2009 Aug; 4(8):1269-72. PubMed ID: 19431162
[No Abstract] [Full Text] [Related]
3. Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
Souto JA; Vaz E; Lepore I; Pöppler AC; Franci G; Alvarez R; Altucci L; de Lera AR
J Med Chem; 2010 Jun; 53(12):4654-67. PubMed ID: 20491440
[TBL] [Abstract][Full Text] [Related]
4. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
Ying Y; Taori K; Kim H; Hong J; Luesch H
J Am Chem Soc; 2008 Jul; 130(26):8455-9. PubMed ID: 18507379
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and activity of largazole analogues with linker and macrocycle modification.
Ying Y; Liu Y; Byeon SR; Kim H; Luesch H; Hong J
Org Lett; 2008 Sep; 10(18):4021-4. PubMed ID: 18707106
[TBL] [Abstract][Full Text] [Related]
6. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.
Poli G; Di Fabio R; Ferrante L; Summa V; Botta M
ChemMedChem; 2017 Dec; 12(23):1917-1926. PubMed ID: 29117473
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
Guerra-Bubb JM; Bowers AA; Smith WB; Paranal R; Estiu G; Wiest O; Bradner JE; Williams RM
Bioorg Med Chem Lett; 2013 Nov; 23(21):6025-8. PubMed ID: 24035339
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological evaluation of largazole zinc-binding group analogs.
Kim B; Ratnayake R; Lee H; Shi G; Zeller SL; Li C; Luesch H; Hong J
Bioorg Med Chem; 2017 Jun; 25(12):3077-3086. PubMed ID: 28416100
[TBL] [Abstract][Full Text] [Related]
9. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
Bhansali P; Hanigan CL; Casero RA; Tillekeratne LM
J Med Chem; 2011 Nov; 54(21):7453-63. PubMed ID: 21936551
[TBL] [Abstract][Full Text] [Related]
10. Evaluation of class I HDAC isoform selectivity of largazole analogues.
Kim B; Park H; Salvador LA; Serrano PE; Kwan JC; Zeller SL; Chen QY; Ryu S; Liu Y; Byeon S; Luesch H; Hong J
Bioorg Med Chem Lett; 2014 Aug; 24(16):3728-31. PubMed ID: 25070421
[TBL] [Abstract][Full Text] [Related]
11. Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.
Li S; Yao H; Xu J; Jiang S
Molecules; 2011 Jun; 16(6):4681-94. PubMed ID: 21654576
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological activity of largazole and derivatives.
Seiser T; Kamena F; Cramer N
Angew Chem Int Ed Engl; 2008; 47(34):6483-5. PubMed ID: 18633950
[No Abstract] [Full Text] [Related]
13. Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.
Bhansali P; Hanigan CL; Perera L; Casero RA; Tillekeratne LM
Eur J Med Chem; 2014 Oct; 86():528-41. PubMed ID: 25203782
[TBL] [Abstract][Full Text] [Related]
14. Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.
Reddy DN; Ballante F; Chuang T; Pirolli A; Marrocco B; Marshall GR
J Med Chem; 2016 Feb; 59(4):1613-33. PubMed ID: 26681404
[TBL] [Abstract][Full Text] [Related]
15. Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells.
Zeng X; Yin B; Hu Z; Liao C; Liu J; Li S; Li Z; Nicklaus MC; Zhou G; Jiang S
Org Lett; 2010 Mar; 12(6):1368-71. PubMed ID: 20184338
[TBL] [Abstract][Full Text] [Related]
16. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.
Almaliti J; Al-Hamashi AA; Negmeldin AT; Hanigan CL; Perera L; Pflum MK; Casero RA; Tillekeratne LM
J Med Chem; 2016 Dec; 59(23):10642-10660. PubMed ID: 27809521
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
Bowers AA; Greshock TJ; West N; Estiu G; Schreiber SL; Wiest O; Williams RM; Bradner JE
J Am Chem Soc; 2009 Mar; 131(8):2900-5. PubMed ID: 19193120
[TBL] [Abstract][Full Text] [Related]
18. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
Bowers A; West N; Taunton J; Schreiber SL; Bradner JE; Williams RM
J Am Chem Soc; 2008 Aug; 130(33):11219-22. PubMed ID: 18642817
[TBL] [Abstract][Full Text] [Related]
19. Efficient solid-phase synthesis of FK228 analogues as potent antitumoral agents.
Di Maro S; Pong RC; Hsieh JT; Ahn JM
J Med Chem; 2008 Nov; 51(21):6639-41. PubMed ID: 18839938
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A.
Zhang B; Shan G; Zheng Y; Yu X; Ruan ZW; Li Y; Lei X
Mar Drugs; 2019 Jun; 17(6):. PubMed ID: 31163697
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]