BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 21422192)

  • 21. In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.
    Pan Y; Abd-Rashid BA; Ismail Z; Ismail R; Mak JW; Pook PC; Er HM; Ong CE
    J Ethnopharmacol; 2010 Jul; 130(2):275-83. PubMed ID: 20457244
    [TBL] [Abstract][Full Text] [Related]  

  • 22. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.
    Wang B; Yang LP; Zhang XZ; Huang SQ; Bartlam M; Zhou SF
    Drug Metab Rev; 2009; 41(4):573-643. PubMed ID: 19645588
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Ligand- and protein-based modeling studies of the inhibitors of human cytochrome P450 2D6 and a virtual screening for potential inhibitors from the Chinese herbal medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap).
    Mo SL; Liu WF; Chen Y; Luo HB; Sun LB; Chen XW; Zhou ZW; Sneed KB; Li CG; Du YM; Liang J; Zhou SF
    Comb Chem High Throughput Screen; 2012 Jan; 15(1):36-80. PubMed ID: 21846324
    [TBL] [Abstract][Full Text] [Related]  

  • 24. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S; Fujimaki Y; Yokoyama H; Okazaki O; Sudo K
    Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The in vitro interaction of dexmedetomidine with human liver microsomal cytochrome P4502D6 (CYP2D6).
    Rodrigues AD; Roberts EM
    Drug Metab Dispos; 1997 May; 25(5):651-5. PubMed ID: 9152607
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development.
    Zhou SF; Liu JP; Lai XS
    Curr Med Chem; 2009; 16(21):2661-805. PubMed ID: 19601803
    [TBL] [Abstract][Full Text] [Related]  

  • 27. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
    Glass SM; Martell CM; Oswalt AK; Osorio-Vasquez V; Cho C; Hicks MJ; Mills JM; Fujiwara R; Glista MJ; Kamath SS; Furge LL
    Drug Metab Dispos; 2018 Aug; 46(8):1106-1117. PubMed ID: 29784728
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Identification of the human cytochromes P450 responsible for atomoxetine metabolism.
    Ring BJ; Gillespie JS; Eckstein JA; Wrighton SA
    Drug Metab Dispos; 2002 Mar; 30(3):319-23. PubMed ID: 11854152
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
    Madeira M; Levine M; Chang TK; Mirfazaelian A; Bellward GD
    Drug Metab Dispos; 2004 Apr; 32(4):460-7. PubMed ID: 16680870
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
    Lim HK; Duczak N; Brougham L; Elliot M; Patel K; Chan K
    Drug Metab Dispos; 2005 Aug; 33(8):1211-9. PubMed ID: 15860655
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Nitidine Chloride Is a Mechanism-Based Inactivator of CYP2D6.
    Mao X; Hu Z; Wang Q; Zhang N; Zhou S; Peng Y; Zheng J
    Drug Metab Dispos; 2018 Aug; 46(8):1137-1145. PubMed ID: 29773554
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common.
    Locuson CW; Hutzler JM; Tracy TS
    Drug Metab Dispos; 2007 Apr; 35(4):614-22. PubMed ID: 17251307
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
    McLaughlin LA; Paine MJ; Kemp CA; Maréchal JD; Flanagan JU; Ward CJ; Sutcliffe MJ; Roberts GC; Wolf CR
    J Biol Chem; 2005 Nov; 280(46):38617-24. PubMed ID: 16162505
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.
    Volotinen M; Turpeinen M; Tolonen A; Uusitalo J; Mäenpää J; Pelkonen O
    Drug Metab Dispos; 2007 Jul; 35(7):1135-41. PubMed ID: 17431033
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Effect of genetic polymorphism on the inhibition of dopamine formation from p-tyramine catalyzed by brain cytochrome P450 2D6.
    Niwa T; Shizuku M; Yamano K
    Arch Biochem Biophys; 2017 Apr; 620():23-27. PubMed ID: 28347660
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Functional and structural characterisation of common cytochrome P450 2D6 allelic variants-roles of Pro34 and Thr107 in catalysis and inhibition.
    Dong AN; Ahemad N; Pan Y; Palanisamy UD; Yiap BC; Ong CE
    Naunyn Schmiedebergs Arch Pharmacol; 2019 Aug; 392(8):1015-1029. PubMed ID: 31025144
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6.
    Jones BC; Hyland R; Ackland M; Tyman CA; Smith DA
    Drug Metab Dispos; 1998 Sep; 26(9):875-82. PubMed ID: 9733666
    [TBL] [Abstract][Full Text] [Related]  

  • 38. P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes.
    Chiba M; Tang C; Neway WE; Williams TM; Desolms SJ; Dinsmore CJ; Wai JS; Lin JH
    Biochem Pharmacol; 2001 Sep; 62(6):773-6. PubMed ID: 11551523
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol.
    Fu Y; Tian X; Han L; Li Y; Peng Y; Zheng J
    Chem Biol Interact; 2020 May; 322():109053. PubMed ID: 32198085
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.
    Niwa T; Murayama N; Yamazaki H
    Curr Drug Metab; 2011 Jun; 12(5):412-35. PubMed ID: 21453270
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.