These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

76 related articles for article (PubMed ID: 21426137)

  • 1. Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.
    Bagley MC; Davis T; Dix MC; Fusillo V; Pigeaux M; Rokicki MJ; Kipling D
    Future Med Chem; 2010 Sep; 2(9):1417-27. PubMed ID: 21426137
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745.
    Bagley MC; Davis T; Dix MC; Fusillo V; Pigeaux M; Rokicki MJ; Kipling D
    J Org Chem; 2009 Nov; 74(21):8336-42. PubMed ID: 19778055
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.
    Bagley MC; Davis T; Dix MC; Rokicki MJ; Kipling D
    Bioorg Med Chem Lett; 2007 Sep; 17(18):5107-10. PubMed ID: 17659871
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor.
    Terajima M; Inoue T; Magari K; Yamazaki H; Higashi Y; Mizuhara H
    Eur J Pharmacol; 2013 Jan; 698(1-3):455-62. PubMed ID: 23183108
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.
    Bagley MC; Dwyer JE; Baashen M; Dix MC; Murziani PG; Rokicki MJ; Kipling D; Davis T
    Org Biomol Chem; 2016 Jan; 14(3):947-56. PubMed ID: 26611938
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.
    Bagley MC; Davis T; Rokicki MJ; Widdowson CS; Kipling D
    Future Med Chem; 2010 Feb; 2(2):193-201. PubMed ID: 21426186
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.
    Bagley MC; Davis T; Dix MC; Murziani PG; Rokicki MJ; Kipling D
    Future Med Chem; 2010 Feb; 2(2):203-13. PubMed ID: 21426187
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity.
    Hill RJ; Dabbagh K; Phippard D; Li C; Suttmann RT; Welch M; Papp E; Song KW; Chang KC; Leaffer D; Kim YN; Roberts RT; Zabka TS; Aud D; Dal Porto J; Manning AM; Peng SL; Goldstein DM; Wong BR
    J Pharmacol Exp Ther; 2008 Dec; 327(3):610-9. PubMed ID: 18776065
    [TBL] [Abstract][Full Text] [Related]  

  • 9. X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
    Azevedo R; van Zeeland M; Raaijmakers H; Kazemier B; de Vlieg J; Oubrie A
    Acta Crystallogr D Biol Crystallogr; 2012 Aug; 68(Pt 8):1041-50. PubMed ID: 22868770
    [TBL] [Abstract][Full Text] [Related]  

  • 10. VX-745. Vertex Pharmaceuticals.
    Haddad JJ
    Curr Opin Investig Drugs; 2001 Aug; 2(8):1070-6. PubMed ID: 11892915
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.
    Bagley MC; Davis T; Murziani PG; Widdowson CS; Kipling D
    Pharmaceuticals (Basel); 2010 Jun; 3(6):1842-1872. PubMed ID: 27713332
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase.
    Chopra P; Kulkarni O; Gupta S; Bajpai M; Kanoje V; Banerjee M; Bansal V; Visaga S; Chatterjee M; Chaira T; Shirumalla RK; Verma AK; Dastidar SG; Sharma G; Ray A
    Int Immunopharmacol; 2010 Apr; 10(4):467-73. PubMed ID: 20093202
    [TBL] [Abstract][Full Text] [Related]  

  • 13. P38 MAP kinase inhibitors: evolution of imidazole-based and pyrido-pyrimidin-2-one lead classes.
    Natarajan SR; Doherty JB
    Curr Top Med Chem; 2005; 5(10):987-1003. PubMed ID: 16178742
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.
    Sabatini S; Manfroni G; Barreca ML; Bauer SM; Gargaro M; Cannalire R; Astolfi A; Brea J; Vacca C; Pirro M; Massari S; Tabarrini O; Loza MI; Fallarino F; Laufer SA; Cecchetti V
    Chem Biol Drug Des; 2015 Oct; 86(4):531-45. PubMed ID: 25589097
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel strategies for inhibition of the p38 MAPK pathway.
    Zhang J; Shen B; Lin A
    Trends Pharmacol Sci; 2007 Jun; 28(6):286-95. PubMed ID: 17482683
    [TBL] [Abstract][Full Text] [Related]  

  • 16. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils.
    Tsai YR; Wang YJ; Lee MR; Hsu MF; Wang JP
    Eur J Pharmacol; 2013 Feb; 701(1-3):96-105. PubMed ID: 23348708
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors.
    Heo J; Shin H; Lee J; Kim T; Inn KS; Kim NJ
    Bioorg Med Chem Lett; 2015 Sep; 25(17):3694-8. PubMed ID: 26115577
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation.
    Kuliopulos A; Mohanlal R; Covic L
    Thromb Haemost; 2004 Dec; 92(6):1387-93. PubMed ID: 15583748
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
    Walker JK; Selness SR; Devraj RV; Hepperle ME; Naing W; Shieh H; Kurambail R; Yang S; Flynn DL; Benson AG; Messing DM; Dice T; Kim T; Lindmark RJ; Monahan JB; Portanova J
    Bioorg Med Chem Lett; 2010 Apr; 20(8):2634-8. PubMed ID: 20227876
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules.
    Luedtke GR; Schinzel K; Tan X; Tester RW; Nashashibi I; Xu YJ; Dugar S; Levy DE; Jung J
    Bioorg Med Chem Lett; 2010 Apr; 20(8):2556-9. PubMed ID: 20346653
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.