BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

344 related articles for article (PubMed ID: 21427202)

  • 1. Glucuronidation of anticancer prodrug PR-104A: species differences, identification of human UDP-glucuronosyltransferases, and implications for therapy.
    Gu Y; Tingle MD; Wilson WR
    J Pharmacol Exp Ther; 2011 Jun; 337(3):692-702. PubMed ID: 21427202
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform.
    Kaji H; Kume T
    Drug Metab Dispos; 2005 Mar; 33(3):403-12. PubMed ID: 15608137
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.
    Gu Y; Atwell GJ; Wilson WR
    Drug Metab Dispos; 2010 Mar; 38(3):498-508. PubMed ID: 20019245
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
    Guise CP; Abbattista MR; Singleton RS; Holford SD; Connolly J; Dachs GU; Fox SB; Pollock R; Harvey J; Guilford P; Doñate F; Wilson WR; Patterson AV
    Cancer Res; 2010 Feb; 70(4):1573-84. PubMed ID: 20145130
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.
    Wen Z; Martin DE; Bullock P; Lee KH; Smith PC
    Drug Metab Dispos; 2007 Mar; 35(3):440-8. PubMed ID: 17151190
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia.
    Guise CP; Wang AT; Theil A; Bridewell DJ; Wilson WR; Patterson AV
    Biochem Pharmacol; 2007 Sep; 74(6):810-20. PubMed ID: 17645874
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.
    Innocenti F; Iyer L; Ramírez J; Green MD; Ratain MJ
    Drug Metab Dispos; 2001 May; 29(5):686-92. PubMed ID: 11302935
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.
    Jamieson SM; Gu Y; Manesh DM; El-Hoss J; Jing D; Mackenzie KL; Guise CP; Foehrenbacher A; Pullen SM; Benito J; Smaill JB; Patterson AV; Mulaw MA; Konopleva M; Bohlander SK; Lock RB; Wilson WR
    Biochem Pharmacol; 2014 Mar; 88(1):36-45. PubMed ID: 24434189
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases.
    Yu L; Lu S; Lin Y; Zeng S
    Biochem Pharmacol; 2007 Jun; 73(11):1842-51. PubMed ID: 17359941
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Assessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs.
    Li T; Zheng Y; Fu F; Ji H; Chen X; Zhao Y; Zhao D; Li N; Zhang L
    Xenobiotica; 2011 Jul; 41(7):530-7. PubMed ID: 21524190
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.
    Yamanaka H; Nakajima M; Katoh M; Kanoh A; Tamura O; Ishibashi H; Yokoi T
    Drug Metab Dispos; 2005 Jan; 33(1):23-30. PubMed ID: 15470160
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.
    Abbattista MR; Jamieson SM; Gu Y; Nickel JE; Pullen SM; Patterson AV; Wilson WR; Guise CP
    Cancer Biol Ther; 2015; 16(4):610-22. PubMed ID: 25869917
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol.
    Chen M; LeDuc B; Kerr S; Howe D; Williams DA
    Drug Metab Dispos; 2010 Mar; 38(3):368-75. PubMed ID: 20008037
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stereoselective glucuronidation of propranolol in human and cynomolgus monkey liver microsomes: role of human hepatic UDP-glucuronosyltransferase isoforms, UGT1A9, UGT2B4 and UGT2B7.
    Hanioka N; Hayashi K; Shimizudani T; Nagaoka K; Koeda A; Naito S; Narimatsu S
    Pharmacology; 2008; 82(4):293-303. PubMed ID: 18936551
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.
    Wang Q; Hao H; Zhu X; Yu G; Lai L; Liu Y; Wang Y; Jiang S; Wang G
    Drug Metab Dispos; 2010 Jul; 38(7):1132-40. PubMed ID: 20382756
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver.
    Yasuda K; Ikushiro S; Kamakura M; Munetsuna E; Ohta M; Sakaki T
    Drug Metab Dispos; 2011 Sep; 39(9):1538-45. PubMed ID: 21622626
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.
    Hanioka N; Naito T; Narimatsu S
    Chemosphere; 2008 Dec; 74(1):33-6. PubMed ID: 18990428
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.
    Patel K; Choy SS; Hicks KO; Melink TJ; Holford NH; Wilson WR
    Cancer Chemother Pharmacol; 2011 May; 67(5):1145-55. PubMed ID: 20683596
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human UDP-glucuronosyltransferase isoforms involved in haloperidol glucuronidation and quantitative estimation of their contribution.
    Kato Y; Nakajima M; Oda S; Fukami T; Yokoi T
    Drug Metab Dispos; 2012 Feb; 40(2):240-8. PubMed ID: 22028316
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
    Singleton RS; Guise CP; Ferry DM; Pullen SM; Dorie MJ; Brown JM; Patterson AV; Wilson WR
    Cancer Res; 2009 May; 69(9):3884-91. PubMed ID: 19366798
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.