These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 21439820)

  • 21. Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
    Kono M; Matsumoto T; Kawamura T; Nishimura A; Kiyota Y; Oki H; Miyazaki J; Igaki S; Behnke CA; Shimojo M; Kori M
    Bioorg Med Chem; 2013 Jan; 21(1):28-41. PubMed ID: 23218778
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.
    Tian X; Mishra RK; Switzer AG; Hu XE; Kim N; Mazur AW; Ebetino FH; Wos JA; Crossdoersen D; Pinney BB; Farmer JA; Sheldon RJ
    Bioorg Med Chem Lett; 2006 Sep; 16(17):4668-73. PubMed ID: 16766182
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.
    Tran JA; Tucci FC; Jiang W; Marinkovic D; Chen CW; Arellano M; Markison S; Fleck BA; Wen J; White NS; Pontillo J; Saunders J; Marks D; Hoare SR; Madan A; Foster AC; Chen C
    Bioorg Med Chem; 2007 Aug; 15(15):5166-76. PubMed ID: 17544282
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
    Xin Z; Serby MD; Zhao H; Kosogof C; Szczepankiewicz BG; Liu M; Liu B; Hutchins CW; Sarris KA; Hoff ED; Falls HD; Lin CW; Ogiela CA; Collins CA; Brune ME; Bush EN; Droz BA; Fey TA; Knourek-Segel VE; Shapiro R; Jacobson PB; Beno DW; Turner TM; Sham HL; Liu G
    J Med Chem; 2006 Jul; 49(15):4459-69. PubMed ID: 16854051
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Gastric mucosal damage following repeat administration of melanocortin subtype-4 receptor ligands to Fischer 344 rats.
    Williams TM; Donnelly KB
    Toxicol Pathol; 2006; 34(6):738-43. PubMed ID: 17162531
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.
    Pontillo J; Tran JA; Arellano M; Fleck BA; Huntley R; Marinkovic D; Lanier M; Nelson J; Parker J; Saunders J; Tucci FC; Jiang W; Chen CW; White NS; Foster AC; Chen C
    Bioorg Med Chem Lett; 2004 Sep; 14(17):4417-23. PubMed ID: 15357964
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.
    Bakshi RK; Hong Q; Tang R; Kalyani RN; Macneil T; Weinberg DH; Van der Ploeg LH; Patchett AA; Nargund RP
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1130-3. PubMed ID: 16364639
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
    Tran JA; Tucci FC; Arellano M; Jiang W; Chen CW; Marinkovic D; Fleck BA; Wen J; Foster AC; Chen C
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1931-8. PubMed ID: 18294847
    [TBL] [Abstract][Full Text] [Related]  

  • 29. A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity.
    Szewczyk JR; Laudeman CP; Sammond DM; Villeneuve M; Minick DJ; Grizzle MK; Daniels AJ; Andrews JL; Ignar DM
    Bioorg Med Chem; 2010 Mar; 18(5):1822-33. PubMed ID: 20172734
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
    Jiang W; Tran JA; Tucci FC; Fleck BA; Hoare SR; Markison S; Wen J; Chen CW; Marinkovic D; Arellano M; Foster AC; Chen C
    Bioorg Med Chem Lett; 2007 Dec; 17(23):6546-52. PubMed ID: 17933528
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation.
    Muceniece R; Zvejniece L; Vilskersts R; Liepinsh E; Baumane L; Kalvinsh I; Wikberg JE; Dambrova M
    Basic Clin Pharmacol Toxicol; 2007 Dec; 101(6):416-20. PubMed ID: 18028105
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
    Kono M; Matsumoto T; Imaeda T; Kawamura T; Fujimoto S; Kosugi Y; Odani T; Shimizu Y; Matsui H; Shimojo M; Kori M
    Bioorg Med Chem; 2014 Feb; 22(4):1468-78. PubMed ID: 24440478
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.
    Nargund RP; Strack AM; Fong TM
    J Med Chem; 2006 Jul; 49(14):4035-43. PubMed ID: 16821763
    [No Abstract]   [Full Text] [Related]  

  • 34. Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
    Chen C; Jiang W; Tran JA; Tucci FC; Fleck BA; Markison S; Wen J; Madan A; Hoare SR; Foster AC; Marinkovic D; Chen CW; Arellano M; Saunders J
    Bioorg Med Chem Lett; 2008 Jan; 18(1):129-36. PubMed ID: 18032040
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.
    Vu CB; Peng B; Kumaravel G; Smits G; Jin X; Phadke D; Engber T; Huang C; Reilly J; Tam S; Grant D; Hetu G; Chen L; Zhang J; Petter RC
    J Med Chem; 2004 Aug; 47(17):4291-9. PubMed ID: 15294001
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.
    Smith BM; Smith JM; Tsai JH; Schultz JA; Gilson CA; Estrada SA; Chen RR; Park DM; Prieto EB; Gallardo CS; Sengupta D; Thomsen WJ; Saldana HR; Whelan KT; Menzaghi F; Webb RR; Beeley NR
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1467-70. PubMed ID: 15713408
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.
    Chaki S; Hirota S; Funakoshi T; Suzuki Y; Suetake S; Okubo T; Ishii T; Nakazato A; Okuyama S
    J Pharmacol Exp Ther; 2003 Feb; 304(2):818-26. PubMed ID: 12538838
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery of a beta-MSH-derived MC-4R selective agonist.
    Mayer JP; Hsiung HM; Flora DB; Edwards P; Smith DP; Zhang XY; Gadski RA; Heiman ML; Hertel JL; Emmerson PJ; Husain S; O'brien TP; Kahl SD; Smiley DL; Zhang L; Dimarchi RD; Yan LZ
    J Med Chem; 2005 May; 48(9):3095-8. PubMed ID: 15857110
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Melanocortin-4 receptor agonists for the treatment of obesity.
    Boyce RS; Duhl DM
    Curr Opin Investig Drugs; 2004 Oct; 5(10):1063-71. PubMed ID: 15535427
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
    Smith ND; Poon SF; Huang D; Green M; King C; Tehrani L; Roppe JR; Chung J; Chapman DP; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5481-4. PubMed ID: 15482908
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.