These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

457 related articles for article (PubMed ID: 21450930)

  • 1. Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke.
    Arumugam TV; Cheng YL; Choi Y; Choi YH; Yang S; Yun YK; Park JS; Yang DK; Thundyil J; Gelderblom M; Karamyan VT; Tang SC; Chan SL; Magnus T; Sobey CG; Jo DG
    Mol Pharmacol; 2011 Jul; 80(1):23-31. PubMed ID: 21450930
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress.
    Cheng YL; Choi Y; Seow WL; Manzanero S; Sobey CG; Jo DG; Arumugam TV
    Brain Res; 2014 Oct; 1586():193-202. PubMed ID: 25168760
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protective role of Bcl-2 on beta-amyloid-induced cell death of differentiated PC12 cells: reduction of NF-kappaB and p38 MAP kinase activation.
    Song YS; Park HJ; Kim SY; Lee SH; Yoo HS; Lee HS; Lee MK; Oh KW; Kang SK; Lee SE; Hong JT
    Neurosci Res; 2004 May; 49(1):69-80. PubMed ID: 15099705
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.
    Cheng YL; Park JS; Manzanero S; Choi Y; Baik SH; Okun E; Gelderblom M; Fann DY; Magnus T; Launikonis BS; Mattson MP; Sobey CG; Jo DG; Arumugam TV
    Neurobiol Dis; 2014 Feb; 62():286-95. PubMed ID: 24141018
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia.
    Stephenson D; Yin T; Smalstig EB; Hsu MA; Panetta J; Little S; Clemens J
    J Cereb Blood Flow Metab; 2000 Mar; 20(3):592-603. PubMed ID: 10724123
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
    Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway.
    Zhang HL; Xu M; Wei C; Qin AP; Liu CF; Hong LZ; Zhao XY; Liu J; Qin ZH
    Neuroscience; 2011 Mar; 176():381-95. PubMed ID: 21185913
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nuclear factor-κB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT.
    Cao Q; Li P; Lu J; Dheen ST; Kaur C; Ling EA
    J Neurosci Res; 2010 Sep; 88(12):2701-14. PubMed ID: 20648656
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.
    Arumugam TV; Chan SL; Jo DG; Yilmaz G; Tang SC; Cheng A; Gleichmann M; Okun E; Dixit VD; Chigurupati S; Mughal MR; Ouyang X; Miele L; Magnus T; Poosala S; Granger DN; Mattson MP
    Nat Med; 2006 Jun; 12(6):621-3. PubMed ID: 16680150
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NF-kappaB dimers in the regulation of neuronal survival.
    Sarnico I; Lanzillotta A; Benarese M; Alghisi M; Baiguera C; Battistin L; Spano P; Pizzi M
    Int Rev Neurobiol; 2009; 85():351-62. PubMed ID: 19607980
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
    Hales EC; Taub JW; Matherly LH
    Cell Signal; 2014 Jan; 26(1):149-61. PubMed ID: 24140475
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity.
    Monsalve E; Ruiz-García A; Baladrón V; Ruiz-Hidalgo MJ; Sánchez-Solana B; Rivero S; García-Ramírez JJ; Rubio A; Laborda J; Díaz-Guerra MJ
    Eur J Immunol; 2009 Sep; 39(9):2556-70. PubMed ID: 19662631
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways.
    Jang ER; Lee CS
    Neurochem Int; 2011 Jan; 58(1):52-9. PubMed ID: 21035514
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells.
    Yao J; Duan L; Fan M; Wu X
    Oral Dis; 2007 Nov; 13(6):555-63. PubMed ID: 17944672
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Contribution of gamma-secretase to calcium-mediated cell death.
    Choi YH; Gwon AR; Jeong HY; Park JS; Baik SH; Arumugam TV; Jo DG
    Neurosci Lett; 2010 Jan; 469(3):425-8. PubMed ID: 20035833
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
    Lewis HD; Leveridge M; Strack PR; Haldon CD; O'neil J; Kim H; Madin A; Hannam JC; Look AT; Kohl N; Draetta G; Harrison T; Kerby JA; Shearman MS; Beher D
    Chem Biol; 2007 Feb; 14(2):209-19. PubMed ID: 17317574
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway.
    Wang HJ; Cao JP; Yu JK; Zhang LC; Jiang ZJ; Gao DS
    Eur J Pharmacol; 2008 Oct; 595(1-3):7-12. PubMed ID: 18703048
    [TBL] [Abstract][Full Text] [Related]  

  • 19. BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs.
    Gozzelino R; Sole C; Llecha N; Segura MF; Moubarak RS; Iglesias-Guimarais V; Perez-Garcia MJ; Reix S; Zhang J; Badiola N; Sanchis D; Rodriguez-Alvarez J; Trullas R; Yuste VJ; Comella JX
    Cell Res; 2008 Oct; 18(10):1020-36. PubMed ID: 18591962
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke.
    Balaganapathy P; Baik SH; Mallilankaraman K; Sobey CG; Jo DG; Arumugam TV
    J Cereb Blood Flow Metab; 2018 Oct; 38(10):1781-1795. PubMed ID: 28617078
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.