231 related articles for article (PubMed ID: 21454586)
1. Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.
Shi Q; Xu H; Yu H; Zhang N; Ye Y; Estevez AG; Deng H; Gibson GE
J Biol Chem; 2011 May; 286(20):17640-8. PubMed ID: 21454586
[TBL] [Abstract][Full Text] [Related]
2. Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.
Shi Q; Xu H; Kleinman WA; Gibson GE
Biochim Biophys Acta; 2008 Apr; 1782(4):229-38. PubMed ID: 18206986
[TBL] [Abstract][Full Text] [Related]
3. Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.
Park LC; Zhang H; Sheu KF; Calingasan NY; Kristal BS; Lindsay JG; Gibson GE
J Neurochem; 1999 May; 72(5):1948-58. PubMed ID: 10217272
[TBL] [Abstract][Full Text] [Related]
4. The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.
Gibson GE; Blass JP; Beal MF; Bunik V
Mol Neurobiol; 2005; 31(1-3):43-63. PubMed ID: 15953811
[TBL] [Abstract][Full Text] [Related]
5. Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.
Shi Q; Karuppagounder SS; Xu H; Pechman D; Chen H; Gibson GE
Neurochem Int; 2007 Jun; 50(7-8):921-31. PubMed ID: 17482317
[TBL] [Abstract][Full Text] [Related]
6. Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors.
Lai JC; Cooper AJ
J Neurochem; 1986 Nov; 47(5):1376-86. PubMed ID: 3760866
[TBL] [Abstract][Full Text] [Related]
7. Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits.
Gibson GE; Park LC; Zhang H; Sorbi S; Calingasan NY
Ann N Y Acad Sci; 1999; 893():79-94. PubMed ID: 10672231
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.
Huang HM; Zhang H; Xu H; Gibson GE
Biochim Biophys Acta; 2003 Jan; 1637(1):119-26. PubMed ID: 12527416
[TBL] [Abstract][Full Text] [Related]
9. Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy.
Park LC; Albers DS; Xu H; Lindsay JG; Beal MF; Gibson GE
J Neurosci Res; 2001 Dec; 66(5):1028-34. PubMed ID: 11746433
[TBL] [Abstract][Full Text] [Related]
10. Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.
Gibson GE; Chen HL; Xu H; Qiu L; Xu Z; Denton TT; Shi Q
Neurobiol Aging; 2012 Jun; 33(6):1121.e13-24. PubMed ID: 22169199
[TBL] [Abstract][Full Text] [Related]
11. Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.
Gibson GE; Xu H; Chen HL; Chen W; Denton TT; Zhang S
J Neurochem; 2015 Jul; 134(1):86-96. PubMed ID: 25772995
[TBL] [Abstract][Full Text] [Related]
12. Consequences of the α-ketoglutarate dehydrogenase inhibition for neuronal metabolism and survival: implications for neurodegenerative diseases.
Trofimova LK; Araújo WL; Strokina AA; Fernie AR; Bettendorff L; Bunik VI
Curr Med Chem; 2012; 19(34):5895-906. PubMed ID: 23061627
[TBL] [Abstract][Full Text] [Related]
13. Brain regional development of the activity of alpha-ketoglutarate dehydrogenase complex in the rat.
Buerstatte CR; Behar KL; Novotny EJ; Lai JC
Brain Res Dev Brain Res; 2000 Dec; 125(1-2):139-45. PubMed ID: 11154769
[TBL] [Abstract][Full Text] [Related]
14. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.
Bunik VI; Denton TT; Xu H; Thompson CM; Cooper AJ; Gibson GE
Biochemistry; 2005 Aug; 44(31):10552-61. PubMed ID: 16060664
[TBL] [Abstract][Full Text] [Related]
15. Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase.
Kish SJ
Ann N Y Acad Sci; 1997 Sep; 826():218-28. PubMed ID: 9329693
[TBL] [Abstract][Full Text] [Related]
16. Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury.
Lee JH; Yang ES; Park JW
J Biol Chem; 2003 Dec; 278(51):51360-71. PubMed ID: 14551203
[TBL] [Abstract][Full Text] [Related]
17. Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.
Mastrogiacomo F; Bergeron C; Kish SJ
J Neurochem; 1993 Dec; 61(6):2007-14. PubMed ID: 8245957
[TBL] [Abstract][Full Text] [Related]
18. Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.
Banerjee K; Munshi S; Xu H; Frank DE; Chen HL; Chu CT; Yang J; Cho S; Kagan VE; Denton TT; Tyurina YY; Jiang JF; Gibson GE
Neurochem Int; 2016 Jun; 96():32-45. PubMed ID: 26923918
[TBL] [Abstract][Full Text] [Related]
19. Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.
Sheu KF; Calingasan NY; Lindsay JG; Gibson GE
J Neurochem; 1998 Mar; 70(3):1143-50. PubMed ID: 9489735
[TBL] [Abstract][Full Text] [Related]
20. Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme.
Gibson GE; Zhang H; Xu H; Park LC; Jeitner TM
Biochim Biophys Acta; 2002 Mar; 1586(2):177-89. PubMed ID: 11959459
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
