201 related articles for article (PubMed ID: 21456530)
1. Zinc chelation with hydroxamate in histone deacetylases modulated by water access to the linker binding channel.
Wu R; Lu Z; Cao Z; Zhang Y
J Am Chem Soc; 2011 Apr; 133(16):6110-3. PubMed ID: 21456530
[TBL] [Abstract][Full Text] [Related]
2. Thiol versus hydroxamate as zinc binding group in HDAC inhibition: An ab initio QM/MM molecular dynamics study.
Gong W; Wu R; Zhang Y
J Comput Chem; 2015 Nov; 36(30):2228-35. PubMed ID: 26452222
[TBL] [Abstract][Full Text] [Related]
3. Computational exploration of zinc binding groups for HDAC inhibition.
Chen K; Xu L; Wiest O
J Org Chem; 2013 May; 78(10):5051-5. PubMed ID: 23586590
[TBL] [Abstract][Full Text] [Related]
4. Structure-function analysis of the conserved tyrosine and diverse π-stacking among class I histone deacetylases: a QM (DFT)/MM MD study.
Zhou J; Xie H; Liu Z; Luo HB; Wu R
J Chem Inf Model; 2014 Nov; 54(11):3162-71. PubMed ID: 25360823
[TBL] [Abstract][Full Text] [Related]
5. A structure-based virtual screening approach toward the discovery of histone deacetylase inhibitors: identification of promising zinc-chelating groups.
Park H; Kim S; Kim YE; Lim SJ
ChemMedChem; 2010 Apr; 5(4):591-7. PubMed ID: 20157916
[TBL] [Abstract][Full Text] [Related]
6. Diarylcyclopropane hydroxamic acid inhibitors of histone deacetylase 4 designed by combinatorial approach and QM/MM calculations.
Kollar J; Frecer V
J Mol Graph Model; 2018 Oct; 85():97-110. PubMed ID: 30145395
[TBL] [Abstract][Full Text] [Related]
7. Quantum polarized ligand docking investigation to understand the significance of protonation states in histone deacetylase inhibitors.
Kalyaanamoorthy S; Chen YP
J Mol Graph Model; 2013 Jul; 44():44-53. PubMed ID: 23732305
[TBL] [Abstract][Full Text] [Related]
8. A cyclodextrin-capped histone deacetylase inhibitor.
Amin J; Puglisi A; Clarke J; Milton J; Wang M; Paranal RM; Bradner JE; Spencer J
Bioorg Med Chem Lett; 2013 Jun; 23(11):3346-8. PubMed ID: 23591111
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Vannini A; Volpari C; Filocamo G; Casavola EC; Brunetti M; Renzoni D; Chakravarty P; Paolini C; De Francesco R; Gallinari P; Steinkühler C; Di Marco S
Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15064-9. PubMed ID: 15477595
[TBL] [Abstract][Full Text] [Related]
10. Zinc binding in HDAC inhibitors: a DFT study.
Wang D; Helquist P; Wiest O
J Org Chem; 2007 Jul; 72(14):5446-9. PubMed ID: 17579460
[TBL] [Abstract][Full Text] [Related]
11. Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.
Rossi C; Porcelloni M; D'Andrea P; Fincham CI; Ettorre A; Mauro S; Squarcia A; Bigioni M; Parlani M; Nardelli F; Binaschi M; Maggi CA; Fattori D
Bioorg Med Chem Lett; 2011 Apr; 21(8):2305-8. PubMed ID: 21420859
[TBL] [Abstract][Full Text] [Related]
12. Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.
Olson DE; Sleiman SF; Bourassa MW; Wagner FF; Gale JP; Zhang YL; Ratan RR; Holson EB
Chem Biol; 2015 Apr; 22(4):439-445. PubMed ID: 25892200
[TBL] [Abstract][Full Text] [Related]
13. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Krennhrubec K; Marshall BL; Hedglin M; Verdin E; Ulrich SM
Bioorg Med Chem Lett; 2007 May; 17(10):2874-8. PubMed ID: 17346959
[TBL] [Abstract][Full Text] [Related]
14. Unexpected deacetylation mechanism suggested by a density functional theory QM/MM study of histone-deacetylase-like protein.
Corminboeuf C; Hu P; Tuckerman ME; Zhang Y
J Am Chem Soc; 2006 Apr; 128(14):4530-1. PubMed ID: 16594663
[TBL] [Abstract][Full Text] [Related]
15. Comparison of three zinc binding groups for HDAC inhibitors - A potency, selectivity and enzymatic kinetics study.
Yue K; Qin M; Huang C; James Chou C; Jiang Y; Li X
Bioorg Med Chem Lett; 2022 Aug; 70():128797. PubMed ID: 35580726
[TBL] [Abstract][Full Text] [Related]
16. Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
Tabackman AA; Frankson R; Marsan ES; Perry K; Cole KE
J Struct Biol; 2016 Sep; 195(3):373-378. PubMed ID: 27374062
[TBL] [Abstract][Full Text] [Related]
17. The Zinc-Binding Group Effect: Lessons from Non-Hydroxamic Acid Vorinostat Analogs.
Geurs S; Clarisse D; De Bosscher K; D'hooghe M
J Med Chem; 2023 Jun; 66(12):7698-7729. PubMed ID: 37276138
[TBL] [Abstract][Full Text] [Related]
18. A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Simoben CV; Robaa D; Chakrabarti A; Schmidtkunz K; Marek M; Lancelot J; Kannan S; Melesina J; Shaik TB; Pierce RJ; Romier C; Jung M; Sippl W
Molecules; 2018 Mar; 23(3):. PubMed ID: 29498707
[TBL] [Abstract][Full Text] [Related]
19. Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases.
Frühauf A; Meyer-Almes FJ
Molecules; 2021 Aug; 26(17):. PubMed ID: 34500583
[TBL] [Abstract][Full Text] [Related]
20. Explorative study on isoform-selective histone deacetylase inhibitors.
Suzuki T
Chem Pharm Bull (Tokyo); 2009 Sep; 57(9):897-906. PubMed ID: 19721249
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]