262 related articles for article (PubMed ID: 21464128)
1. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Lim KG; Tonelli F; Li Z; Lu X; Bittman R; Pyne S; Pyne NJ
J Biol Chem; 2011 May; 286(21):18633-40. PubMed ID: 21464128
[TBL] [Abstract][Full Text] [Related]
2. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F; Lim KG; Loveridge C; Long J; Pitson SM; Tigyi G; Bittman R; Pyne S; Pyne NJ
Cell Signal; 2010 Oct; 22(10):1536-42. PubMed ID: 20570726
[TBL] [Abstract][Full Text] [Related]
3. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Lim KG; Sun C; Bittman R; Pyne NJ; Pyne S
Cell Signal; 2011 Oct; 23(10):1590-5. PubMed ID: 21620961
[TBL] [Abstract][Full Text] [Related]
4. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Nagaoka Y; Otsuki K; Fujita T; Uesato S
Biol Pharm Bull; 2008 Jun; 31(6):1177-81. PubMed ID: 18520051
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of selective inhibitors of sphingosine kinase 1.
Baek DJ; MacRitchie N; Pyne NJ; Pyne S; Bittman R
Chem Commun (Camb); 2013 Mar; 49(21):2136-8. PubMed ID: 23388656
[TBL] [Abstract][Full Text] [Related]
6. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Lim KG; Tonelli F; Berdyshev E; Gorshkova I; Leclercq T; Pitson SM; Bittman R; Pyne S; Pyne NJ
Int J Biochem Cell Biol; 2012 Sep; 44(9):1457-64. PubMed ID: 22634604
[TBL] [Abstract][Full Text] [Related]
7. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Tonelli F; Alossaimi M; Williamson L; Tate RJ; Watson DG; Chan E; Bittman R; Pyne NJ; Pyne S
Br J Pharmacol; 2013 Mar; 168(6):1497-505. PubMed ID: 23113536
[TBL] [Abstract][Full Text] [Related]
8. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Lee JW; Ryu JY; Yoon G; Jeon HK; Cho YJ; Choi JJ; Song SY; Do IG; Lee YY; Kim TJ; Choi CH; Kim BG; Bae DS
Int J Cancer; 2015 Jul; 137(1):221-9. PubMed ID: 25429856
[TBL] [Abstract][Full Text] [Related]
9. FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
Spijkers LJ; Alewijnse AE; Peters SL
Br J Pharmacol; 2012 Jun; 166(4):1411-8. PubMed ID: 22251137
[TBL] [Abstract][Full Text] [Related]
10. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
Adams DR; Pyne S; Pyne NJ
Cell Signal; 2020 Dec; 76():109806. PubMed ID: 33035646
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.
Liu Z; MacRitchie N; Pyne S; Pyne NJ; Bittman R
Bioorg Med Chem; 2013 May; 21(9):2503-10. PubMed ID: 23541833
[TBL] [Abstract][Full Text] [Related]
12. Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
Högenauer K; Billich A; Pally C; Streiff M; Wagner T; Welzenbach K; Nussbaumer P
ChemMedChem; 2008 Jul; 3(7):1027-9. PubMed ID: 18383466
[No Abstract] [Full Text] [Related]
13. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
Oo ML; Thangada S; Wu MT; Liu CH; Macdonald TL; Lynch KR; Lin CY; Hla T
J Biol Chem; 2007 Mar; 282(12):9082-9. PubMed ID: 17237497
[TBL] [Abstract][Full Text] [Related]
14. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Vessey DA; Kelley M; Zhang J; Li L; Tao R; Karliner JS
J Biochem Mol Toxicol; 2007; 21(5):273-9. PubMed ID: 17912702
[TBL] [Abstract][Full Text] [Related]
15. Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
Butler J; Lana D; Round O; LaMontagne K
Prostaglandins Other Lipid Mediat; 2004 Jan; 73(1-2):29-45. PubMed ID: 15165029
[TBL] [Abstract][Full Text] [Related]
16. Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
Lu X; Sun C; Valentine WJ; Shuyu E; Liu J; Tigyi G; Bittman R
J Org Chem; 2009 Apr; 74(8):3192-5. PubMed ID: 19296586
[TBL] [Abstract][Full Text] [Related]
17. Molecular targets of FTY720 (fingolimod).
Pitman MR; Woodcock JM; Lopez AF; Pitson SM
Curr Mol Med; 2012 Dec; 12(10):1207-19. PubMed ID: 22834825
[TBL] [Abstract][Full Text] [Related]
18. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C; Tonelli F; Leclercq T; Lim KG; Long JS; Berdyshev E; Tate RJ; Natarajan V; Pitson SM; Pyne NJ; Pyne S
J Biol Chem; 2010 Dec; 285(50):38841-52. PubMed ID: 20926375
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Raje MR; Knott K; Kharel Y; Bissel P; Lynch KR; Santos WL
Bioorg Med Chem; 2012 Jan; 20(1):183-94. PubMed ID: 22137932
[TBL] [Abstract][Full Text] [Related]
20. Targeting sphingosine-1-phosphate in hematologic malignancies.
Stevenson CE; Takabe K; Nagahashi M; Milstien S; Spiegel S
Anticancer Agents Med Chem; 2011 Nov; 11(9):794-8. PubMed ID: 21707492
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
