223 related articles for article (PubMed ID: 21473615)
1. Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.
Atkins WM; Qian H
Biochemistry; 2011 May; 50(19):3866-72. PubMed ID: 21473615
[TBL] [Abstract][Full Text] [Related]
2. Enzymatic detoxication, conformational selection, and the role of molten globule active sites.
Honaker MT; Acchione M; Zhang W; Mannervik B; Atkins WM
J Biol Chem; 2013 Jun; 288(25):18599-611. PubMed ID: 23649628
[TBL] [Abstract][Full Text] [Related]
3. Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity.
Atkins WM
J Steroid Biochem Mol Biol; 2015 Jul; 151():3-11. PubMed ID: 25218442
[TBL] [Abstract][Full Text] [Related]
4. Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme.
Honaker MT; Acchione M; Sumida JP; Atkins WM
J Biol Chem; 2011 Dec; 286(49):42770-42776. PubMed ID: 22002059
[TBL] [Abstract][Full Text] [Related]
5. Unusual commonality in active site structural features of substrate promiscuous and specialist enzymes.
Thakur D; Pandit SB
J Struct Biol; 2022 Mar; 214(1):107835. PubMed ID: 35104611
[TBL] [Abstract][Full Text] [Related]
6. Protein promiscuity: drug resistance and native functions--HIV-1 case.
Fernández A; Tawfik DS; Berkhout B; Sanders R; Kloczkowski A; Sen T; Jernigan B
J Biomol Struct Dyn; 2005 Jun; 22(6):615-24. PubMed ID: 15842167
[TBL] [Abstract][Full Text] [Related]
7. Conformational states of cytochrome P450cam revealed by trapping of synthetic molecular wires.
Hays AM; Dunn AR; Chiu R; Gray HB; Stout CD; Goodin DB
J Mol Biol; 2004 Nov; 344(2):455-69. PubMed ID: 15522298
[TBL] [Abstract][Full Text] [Related]
8. Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.
Ritchie TK; Kwon H; Atkins WM
J Biol Chem; 2011 Nov; 286(45):39489-96. PubMed ID: 21937435
[TBL] [Abstract][Full Text] [Related]
9. Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function.
Foti RS; Honaker M; Nath A; Pearson JT; Buttrick B; Isoherranen N; Atkins WM
Biochemistry; 2011 Apr; 50(13):2387-93. PubMed ID: 21370922
[TBL] [Abstract][Full Text] [Related]
10. Enzyme Promiscuous Activity: How to Define it and its Evolutionary Aspects.
De Luca V; Mandrich L
Protein Pept Lett; 2020; 27(5):400-410. PubMed ID: 31868141
[TBL] [Abstract][Full Text] [Related]
11. What Your Crystal Structure Will Not Tell You about Enzyme Function.
Pochapsky TC; Pochapsky SS
Acc Chem Res; 2019 May; 52(5):1409-1418. PubMed ID: 31034199
[TBL] [Abstract][Full Text] [Related]
12. Transition-state ensemble in enzyme catalysis: possibility, reality, or necessity?
Ma B; Kumar S; Tsai CJ; Hu Z; Nussinov R
J Theor Biol; 2000 Apr; 203(4):383-97. PubMed ID: 10736215
[TBL] [Abstract][Full Text] [Related]
13. Is there a toxicological advantage for non-hyperbolic kinetics in cytochrome P450 catalysis? Functional allostery from "distributive catalysis".
Atkins WM; Lu WD; Cook DL
J Biol Chem; 2002 Sep; 277(36):33258-66. PubMed ID: 12082118
[TBL] [Abstract][Full Text] [Related]
14. Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.
Pabis A; Duarte F; Kamerlin SC
Biochemistry; 2016 Jun; 55(22):3061-81. PubMed ID: 27187273
[TBL] [Abstract][Full Text] [Related]
15. A quantitative index of substrate promiscuity.
Nath A; Atkins WM
Biochemistry; 2008 Jan; 47(1):157-66. PubMed ID: 18081310
[TBL] [Abstract][Full Text] [Related]
16. Protein conformational populations and functionally relevant substates.
Ramanathan A; Savol A; Burger V; Chennubhotla CS; Agarwal PK
Acc Chem Res; 2014 Jan; 47(1):149-56. PubMed ID: 23988159
[TBL] [Abstract][Full Text] [Related]
17. Mechanisms of promiscuity among drug metabolizing enzymes and drug transporters.
Atkins WM
FEBS J; 2020 Apr; 287(7):1306-1322. PubMed ID: 31663687
[TBL] [Abstract][Full Text] [Related]
18. The dynamical nature of enzymatic catalysis.
Callender R; Dyer RB
Acc Chem Res; 2015 Feb; 48(2):407-13. PubMed ID: 25539144
[TBL] [Abstract][Full Text] [Related]
19. Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification.
Iyanagi T
Int Rev Cytol; 2007; 260():35-112. PubMed ID: 17482904
[TBL] [Abstract][Full Text] [Related]
20. Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP; Wilkey CJ; Phan TTN
J Biol Chem; 2019 Jul; 294(28):10928-10941. PubMed ID: 31147443
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]