These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 21486036)

  • 1. OMP decarboxylase: phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate.
    Goryanova B; Amyes TL; Gerlt JA; Richard JP
    J Am Chem Soc; 2011 May; 133(17):6545-8. PubMed ID: 21486036
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.
    Goryanova B; Goldman LM; Amyes TL; Gerlt JA; Richard JP
    Biochemistry; 2013 Oct; 52(42):7500-11. PubMed ID: 24053466
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.
    Goryanova B; Spong K; Amyes TL; Richard JP
    Biochemistry; 2013 Jan; 52(3):537-46. PubMed ID: 23276261
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization.
    Goryanova B; Amyes TL; Richard JP
    J Am Chem Soc; 2019 Aug; 141(34):13468-13478. PubMed ID: 31365243
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.
    Tsang WY; Wood BM; Wong FM; Wu W; Gerlt JA; Amyes TL; Richard JP
    J Am Chem Soc; 2012 Sep; 134(35):14580-94. PubMed ID: 22812629
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protein-Ribofuranosyl Interactions Activate Orotidine 5'-Monophosphate Decarboxylase for Catalysis.
    Cristobal JR; Brandão TAS; Reyes AC; Richard JP
    Biochemistry; 2021 Nov; 60(45):3362-3373. PubMed ID: 34726391
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.
    Richard JP; Amyes TL; Reyes AC
    Acc Chem Res; 2018 Apr; 51(4):960-969. PubMed ID: 29595949
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts.
    Amyes TL; Richard JP; Tait JJ
    J Am Chem Soc; 2005 Nov; 127(45):15708-9. PubMed ID: 16277505
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.
    Amyes TL; Ming SA; Goldman LM; Wood BM; Desai BJ; Gerlt JA; Richard JP
    Biochemistry; 2012 Jun; 51(23):4630-2. PubMed ID: 22620855
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.
    Goldman LM; Amyes TL; Goryanova B; Gerlt JA; Richard JP
    J Am Chem Soc; 2014 Jul; 136(28):10156-65. PubMed ID: 24958125
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes.
    Reyes AC; Amyes TL; Richard JP
    J Am Chem Soc; 2017 Nov; 139(45):16048-16051. PubMed ID: 29058891
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.
    Toth K; Amyes TL; Wood BM; Chan K; Gerlt JA; Richard JP
    J Am Chem Soc; 2010 May; 132(20):7018-24. PubMed ID: 20441167
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms.
    Toth K; Amyes TL; Wood BM; Chan KK; Gerlt JA; Richard JP
    Biochemistry; 2009 Aug; 48(33):8006-13. PubMed ID: 19618917
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Specificity in transition state binding: the Pauling model revisited.
    Amyes TL; Richard JP
    Biochemistry; 2013 Mar; 52(12):2021-35. PubMed ID: 23327224
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture.
    Reyes AC; Zhai X; Morgan KT; Reinhardt CJ; Amyes TL; Richard JP
    J Am Chem Soc; 2015 Jan; 137(3):1372-82. PubMed ID: 25555107
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.
    Barnett SA; Amyes TL; Wood BM; Gerlt JA; Richard JP
    Biochemistry; 2008 Jul; 47(30):7785-7. PubMed ID: 18598058
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.
    Wood BM; Chan KK; Amyes TL; Richard JP; Gerlt JA
    Biochemistry; 2009 Jun; 48(24):5510-7. PubMed ID: 19435313
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase.
    Sievers A; Wolfenden R
    J Am Chem Soc; 2002 Nov; 124(47):13986-7. PubMed ID: 12440884
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.
    Desai BJ; Wood BM; Fedorov AA; Fedorov EV; Goryanova B; Amyes TL; Richard JP; Almo SC; Gerlt JA
    Biochemistry; 2012 Oct; 51(43):8665-78. PubMed ID: 23030629
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase.
    Yew WS; Wise EL; Rayment I; Gerlt JA
    Biochemistry; 2004 Jun; 43(21):6427-37. PubMed ID: 15157077
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.