BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

191 related articles for article (PubMed ID: 21486697)

  • 1. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors.
    Mayorov AV; Cai M; Palmer ES; Tanaka DK; Cain JP; Dedek MM; Tan B; Trivedi D; Hruby VJ
    Bioorg Med Chem Lett; 2011 May; 21(10):3099-102. PubMed ID: 21486697
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors.
    Mayorov AV; Cai M; Palmer ES; Liu Z; Cain JP; Vagner J; Trivedi D; Hruby VJ
    Peptides; 2010 Oct; 31(10):1894-905. PubMed ID: 20688117
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity.
    Joseph CG; Wilczynski A; Holder JR; Xiang Z; Bauzo RM; Scott JW; Haskell-Luevano C
    Peptides; 2003 Dec; 24(12):1899-908. PubMed ID: 15127941
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
    Hruby VJ; Lu D; Sharma SD; Castrucci AL; Kesterson RA; al-Obeidi FA; Hadley ME; Cone RD
    J Med Chem; 1995 Sep; 38(18):3454-61. PubMed ID: 7658432
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants.
    Haskell-Luevano C; Cone RD; Monck EK; Wan YP
    Biochemistry; 2001 May; 40(20):6164-79. PubMed ID: 11352754
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
    Wilczynski A; Wang XS; Joseph CG; Xiang Z; Bauzo RM; Scott JW; Sorensen NB; Shaw AM; Millard WJ; Richards NG; Haskell-Luevano C
    J Med Chem; 2004 Apr; 47(9):2194-207. PubMed ID: 15084118
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel agouti-related-protein-based melanocortin-1 receptor antagonist.
    Thirumoorthy R; Holder JR; Bauzo RM; Richards NG; Edison AS; Haskell-Luevano C
    J Med Chem; 2001 Nov; 44(24):4114-24. PubMed ID: 11708914
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors.
    Jackson PJ; Yu B; Hunrichs B; Thompson DA; Chai B; Gantz I; Millhauser GL
    Peptides; 2005 Oct; 26(10):1978-87. PubMed ID: 16009463
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of Agouti-related protein binding to melanocortin receptors.
    Yang YK; Thompson DA; Dickinson CJ; Wilken J; Barsh GS; Kent SB; Gantz I
    Mol Endocrinol; 1999 Jan; 13(1):148-55. PubMed ID: 9892020
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.
    Tota MR; Smith TS; Mao C; MacNeil T; Mosley RT; Van der Ploeg LH; Fong TM
    Biochemistry; 1999 Jan; 38(3):897-904. PubMed ID: 9893984
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors.
    Kim MS; Small CJ; Russell SH; Morgan DG; Abbott CR; alAhmed SH; Hay DL; Ghatei MA; Smith DM; Bloom SR
    J Neuroendocrinol; 2002 Apr; 14(4):276-82. PubMed ID: 11963824
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Macrocyclic Agouti-Related Protein/[Nle
    Ericson MD; Freeman KT; Schnell SM; Haskell-Luevano C
    J Med Chem; 2017 Jan; 60(2):805-813. PubMed ID: 28045525
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands.
    Pritchard LE; Armstrong D; Davies N; Oliver RL; Schmitz CA; Brennand JC; Wilkinson GF; White A
    J Endocrinol; 2004 Jan; 180(1):183-91. PubMed ID: 14709157
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular determinants of ligand binding to the human melanocortin-4 receptor.
    Yang YK; Fong TM; Dickinson CJ; Mao C; Li JY; Tota MR; Mosley R; Van Der Ploeg LH; Gantz I
    Biochemistry; 2000 Dec; 39(48):14900-11. PubMed ID: 11101306
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
    Xiang Z; Proneth B; Dirain ML; Litherland SA; Haskell-Luevano C
    Biochemistry; 2010 Jun; 49(22):4583-600. PubMed ID: 20462274
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Peptoid mimics of agouti related protein.
    Thompson DA; Chai BX; Rood HL; Siani MA; Douglas NR; Gantz I; Millhauser GL
    Bioorg Med Chem Lett; 2003 Apr; 13(8):1409-13. PubMed ID: 12668001
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
    Wilczynski A; Wilson KR; Scott JW; Edison AS; Haskell-Luevano C
    J Med Chem; 2005 Apr; 48(8):3060-75. PubMed ID: 15828845
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The interaction of MC3R and MC4R with MRAP2, ACTH, α-MSH and AgRP in chickens.
    Zhang J; Li X; Zhou Y; Cui L; Li J; Wu C; Wan Y; Li J; Wang Y
    J Endocrinol; 2017 Aug; 234(2):155-174. PubMed ID: 28512117
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.
    Ollmann MM; Lamoreux ML; Wilson BD; Barsh GS
    Genes Dev; 1998 Feb; 12(3):316-30. PubMed ID: 9450927
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs.
    Mayorov AV; Han SY; Cai M; Hammer MR; Trivedi D; Hruby VJ
    Chem Biol Drug Des; 2006 May; 67(5):329-35. PubMed ID: 16784457
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.