255 related articles for article (PubMed ID: 21505183)
1. Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.
Tinsley HN; Gary BD; Keeton AB; Lu W; Li Y; Piazza GA
Cancer Prev Res (Phila); 2011 Aug; 4(8):1275-84. PubMed ID: 21505183
[TBL] [Abstract][Full Text] [Related]
2. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Li N; Xi Y; Tinsley HN; Gurpinar E; Gary BD; Zhu B; Li Y; Chen X; Keeton AB; Abadi AH; Moyer MP; Grizzle WE; Chang WC; Clapper ML; Piazza GA
Mol Cancer Ther; 2013 Sep; 12(9):1848-59. PubMed ID: 23804703
[TBL] [Abstract][Full Text] [Related]
3. A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
Whitt JD; Li N; Tinsley HN; Chen X; Zhang W; Li Y; Gary BD; Keeton AB; Xi Y; Abadi AH; Grizzle WE; Piazza GA
Cancer Prev Res (Phila); 2012 Jun; 5(6):822-33. PubMed ID: 22556201
[TBL] [Abstract][Full Text] [Related]
4. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.
Tinsley HN; Gary BD; Keeton AB; Zhang W; Abadi AH; Reynolds RC; Piazza GA
Mol Cancer Ther; 2009 Dec; 8(12):3331-40. PubMed ID: 19996273
[TBL] [Abstract][Full Text] [Related]
5. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
Tinsley HN; Gary BD; Thaiparambil J; Li N; Lu W; Li Y; Maxuitenko YY; Keeton AB; Piazza GA
Cancer Prev Res (Phila); 2010 Oct; 3(10):1303-13. PubMed ID: 20876730
[TBL] [Abstract][Full Text] [Related]
6. Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.
Li N; Chen X; Zhu B; Ramírez-Alcántara V; Canzoneri JC; Lee K; Sigler S; Gary B; Li Y; Zhang W; Moyer MP; Salter EA; Wierzbicki A; Keeton AB; Piazza GA
Oncotarget; 2015 Sep; 6(29):27403-15. PubMed ID: 26299804
[TBL] [Abstract][Full Text] [Related]
7. Essential role of the cGMP/PKG signaling pathway in regulating the proliferation and survival of human renal carcinoma cells.
Ren Y; Zheng J; Yao X; Weng G; Wu L
Int J Mol Med; 2014 Nov; 34(5):1430-8. PubMed ID: 25244411
[TBL] [Abstract][Full Text] [Related]
8. PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity.
Piazza GA; Ward A; Chen X; Maxuitenko Y; Coley A; Aboelella NS; Buchsbaum DJ; Boyd MR; Keeton AB; Zhou G
Drug Discov Today; 2020 Aug; 25(8):1521-1527. PubMed ID: 32562844
[TBL] [Abstract][Full Text] [Related]
9. Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
Thompson WJ; Piazza GA; Li H; Liu L; Fetter J; Zhu B; Sperl G; Ahnen D; Pamukcu R
Cancer Res; 2000 Jul; 60(13):3338-42. PubMed ID: 10910034
[TBL] [Abstract][Full Text] [Related]
10. Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats.
Tinsley HN; Mathew B; Chen X; Maxuitenko YY; Li N; Lowe WM; Whitt JD; Zhang W; Gary BD; Keeton AB; Grizzle WE; Grubbs CJ; Reynolds RC; Piazza GA
Cancers (Basel); 2023 Jan; 15(3):. PubMed ID: 36765604
[TBL] [Abstract][Full Text] [Related]
11. Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.
Piazza GA; Thompson WJ; Pamukcu R; Alila HW; Whitehead CM; Liu L; Fetter JR; Gresh WE; Klein-Szanto AJ; Farnell DR; Eto I; Grubbs CJ
Cancer Res; 2001 May; 61(10):3961-8. PubMed ID: 11358813
[TBL] [Abstract][Full Text] [Related]
12. Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines.
Boon EM; Keller JJ; Wormhoudt TA; Giardiello FM; Offerhaus GJ; van der Neut R; Pals ST
Br J Cancer; 2004 Jan; 90(1):224-9. PubMed ID: 14710233
[TBL] [Abstract][Full Text] [Related]
13. Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
Liu L; Li H; Underwood T; Lloyd M; David M; Sperl G; Pamukcu R; Thompson WJ
J Pharmacol Exp Ther; 2001 Nov; 299(2):583-92. PubMed ID: 11602670
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.
Gong Y; Xu CY; Wang JR; Hu XH; Hong D; Ji X; Shi W; Chen HX; Wang HB; Wu XM
Cell Death Dis; 2014 Nov; 5(11):e1544. PubMed ID: 25429621
[TBL] [Abstract][Full Text] [Related]
15. Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway.
Liu N; Mei L; Fan X; Tang C; Ji X; Hu X; Shi W; Qian Y; Hussain M; Wu J; Wang C; Lin S; Wu X
Cancer Lett; 2016 Aug; 378(1):38-50. PubMed ID: 27179930
[TBL] [Abstract][Full Text] [Related]
16. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.
Preet R; Mohapatra P; Das D; Satapathy SR; Choudhuri T; Wyatt MD; Kundu CN
Carcinogenesis; 2013 Feb; 34(2):277-86. PubMed ID: 23129580
[TBL] [Abstract][Full Text] [Related]
17. Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.
Rice PL; Peters SL; Beard KS; Ahnen DJ
Mol Cancer Ther; 2006 Mar; 5(3):746-54. PubMed ID: 16546990
[TBL] [Abstract][Full Text] [Related]
18. Intervening in β-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis.
Stein U; Arlt F; Smith J; Sack U; Herrmann P; Walther W; Lemm M; Fichtner I; Shoemaker RH; Schlag PM
Neoplasia; 2011 Feb; 13(2):131-44. PubMed ID: 21403839
[TBL] [Abstract][Full Text] [Related]
19. The inhibition of Wnt/β-catenin signaling pathway in human colon cancer cells by sulindac.
Tai WP; Hu PJ; Wu J; Lin XC
Tumori; 2014; 100(1):97-101. PubMed ID: 24675499
[TBL] [Abstract][Full Text] [Related]
20. Activation of cGMP/PKG/p65 signaling associated with PDE5-Is downregulates CCL5 secretion by CD8
Jin S; Xiang P; Liu J; Yang Y; Hu S; Sheng J; He Q; Yu W; Han W; Jin J; Peng J
Prostate; 2019 Jun; 79(8):909-919. PubMed ID: 30958912
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
