276 related articles for article (PubMed ID: 21517780)
1. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.
Hedstrom L; Liechti G; Goldberg JB; Gollapalli DR
Curr Med Chem; 2011; 18(13):1909-18. PubMed ID: 21517780
[TBL] [Abstract][Full Text] [Related]
2. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
Makowska-Grzyska M; Kim Y; Maltseva N; Osipiuk J; Gu M; Zhang M; Mandapati K; Gollapalli DR; Gorla SK; Hedstrom L; Joachimiak A
J Biol Chem; 2015 Feb; 290(9):5893-911. PubMed ID: 25572472
[TBL] [Abstract][Full Text] [Related]
3. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
Makowska-Grzyska M; Kim Y; Wu R; Wilton R; Gollapalli DR; Wang XK; Zhang R; Jedrzejczak R; Mack JC; Maltseva N; Mulligan R; Binkowski TA; Gornicki P; Kuhn ML; Anderson WF; Hedstrom L; Joachimiak A
Biochemistry; 2012 Aug; 51(31):6148-63. PubMed ID: 22788966
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2.
Shah CP; Purushothaman G; Thiruvenkatam V; Kirubakaran S; Juvale K; Kharkar PS
Bioorg Chem; 2019 Jun; 87():753-764. PubMed ID: 30974298
[TBL] [Abstract][Full Text] [Related]
5. Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.
Shah CP; Kharkar PS
Future Med Chem; 2015; 7(11):1415-29. PubMed ID: 26230881
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and In Vitro Enzymatic Studies of New 3-Aryldiazenyl Indoles as Promising Helicobacter pylori IMPDH Inhibitors.
Jangra S; Purushothaman G; Juvale K; Ravi S; Menon A; Thiruvenkatam V; Kirubakaran S
Curr Top Med Chem; 2019; 19(5):376-382. PubMed ID: 30827248
[TBL] [Abstract][Full Text] [Related]
7. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.
Digits JA; Hedstrom L
Biochemistry; 1999 Nov; 38(46):15388-97. PubMed ID: 10563825
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors.
Sahu NU; Purushothaman G; Thiruvenkatam V; Kharkar PS
Drug Dev Res; 2019 Feb; 80(1):125-132. PubMed ID: 30381846
[TBL] [Abstract][Full Text] [Related]
9. Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.
Gollapalli DR; Macpherson IS; Liechti G; Gorla SK; Goldberg JB; Hedstrom L
Chem Biol; 2010 Oct; 17(10):1084-91. PubMed ID: 21035731
[TBL] [Abstract][Full Text] [Related]
10. Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.
Nair V; Shu Q
Antivir Chem Chemother; 2007; 18(5):245-58. PubMed ID: 18046958
[TBL] [Abstract][Full Text] [Related]
11. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
Mandapati K; Gorla SK; House AL; McKenney ES; Zhang M; Rao SN; Gollapalli DR; Mann BJ; Goldberg JB; Cuny GD; Glomski IJ; Hedstrom L
ACS Med Chem Lett; 2014 Aug; 5(8):846-50. PubMed ID: 25147601
[TBL] [Abstract][Full Text] [Related]
12. Inosine 5'-Monophosphate Dehydrogenase (IMPDH) as a Potential Target for the Development of a New Generation of Antiprotozoan Agents.
Fotie J
Mini Rev Med Chem; 2018; 18(8):656-671. PubMed ID: 27334467
[TBL] [Abstract][Full Text] [Related]
13. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.
Macpherson IS; Kirubakaran S; Gorla SK; Riera TV; D'Aquino JA; Zhang M; Cuny GD; Hedstrom L
J Am Chem Soc; 2010 Feb; 132(4):1230-1. PubMed ID: 20052976
[TBL] [Abstract][Full Text] [Related]
14. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors.
Lee S; Ku AF; Vippila MR; Wang Y; Zhang M; Wang X; Hedstrom L; Cuny GD
Bioorg Med Chem Lett; 2020 Dec; 30(24):127543. PubMed ID: 32931912
[TBL] [Abstract][Full Text] [Related]
15. Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.
Sarwono AEY; Mitsuhashi S; Kabir MHB; Shigetomi K; Okada T; Ohsaka F; Otsuguro S; Maenaka K; Igarashi M; Kato K; Ubukata M
J Enzyme Inhib Med Chem; 2019 Dec; 34(1):171-178. PubMed ID: 30451014
[TBL] [Abstract][Full Text] [Related]
16. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
Trapero A; Pacitto A; Chan DS; Abell C; Blundell TL; Ascher DB; Coyne AG
Bioorg Med Chem Lett; 2020 Jan; 30(2):126792. PubMed ID: 31757668
[TBL] [Abstract][Full Text] [Related]
17. The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
Sintchak MD; Nimmesgern E
Immunopharmacology; 2000 May; 47(2-3):163-84. PubMed ID: 10878288
[TBL] [Abstract][Full Text] [Related]
18. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
Prosise GL; Luecke H
J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
[TBL] [Abstract][Full Text] [Related]
19. [The determination and clinical application of inosine 5’-monophosphate dehydrogenase activity].
Liu FY; Qiu XY; Jiao Z
Yao Xue Xue Bao; 2016 Nov; 51(11):1666-73. PubMed ID: 29908108
[TBL] [Abstract][Full Text] [Related]
20. IMP dehydrogenase: the dynamics of drug selectivity.
Hedstrom L; Gan L; Schlippe YG; Riera T; Seyedsayamdost M
Nucleic Acids Res Suppl; 2003; (3):97-8. PubMed ID: 14510398
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
