These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

276 related articles for article (PubMed ID: 21517780)

  • 1. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.
    Hedstrom L; Liechti G; Goldberg JB; Gollapalli DR
    Curr Med Chem; 2011; 18(13):1909-18. PubMed ID: 21517780
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
    Makowska-Grzyska M; Kim Y; Maltseva N; Osipiuk J; Gu M; Zhang M; Mandapati K; Gollapalli DR; Gorla SK; Hedstrom L; Joachimiak A
    J Biol Chem; 2015 Feb; 290(9):5893-911. PubMed ID: 25572472
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
    Makowska-Grzyska M; Kim Y; Wu R; Wilton R; Gollapalli DR; Wang XK; Zhang R; Jedrzejczak R; Mack JC; Maltseva N; Mulligan R; Binkowski TA; Gornicki P; Kuhn ML; Anderson WF; Hedstrom L; Joachimiak A
    Biochemistry; 2012 Aug; 51(31):6148-63. PubMed ID: 22788966
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2.
    Shah CP; Purushothaman G; Thiruvenkatam V; Kirubakaran S; Juvale K; Kharkar PS
    Bioorg Chem; 2019 Jun; 87():753-764. PubMed ID: 30974298
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.
    Shah CP; Kharkar PS
    Future Med Chem; 2015; 7(11):1415-29. PubMed ID: 26230881
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and In Vitro Enzymatic Studies of New 3-Aryldiazenyl Indoles as Promising Helicobacter pylori IMPDH Inhibitors.
    Jangra S; Purushothaman G; Juvale K; Ravi S; Menon A; Thiruvenkatam V; Kirubakaran S
    Curr Top Med Chem; 2019; 19(5):376-382. PubMed ID: 30827248
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.
    Digits JA; Hedstrom L
    Biochemistry; 1999 Nov; 38(46):15388-97. PubMed ID: 10563825
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors.
    Sahu NU; Purushothaman G; Thiruvenkatam V; Kharkar PS
    Drug Dev Res; 2019 Feb; 80(1):125-132. PubMed ID: 30381846
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.
    Gollapalli DR; Macpherson IS; Liechti G; Gorla SK; Goldberg JB; Hedstrom L
    Chem Biol; 2010 Oct; 17(10):1084-91. PubMed ID: 21035731
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.
    Nair V; Shu Q
    Antivir Chem Chemother; 2007; 18(5):245-58. PubMed ID: 18046958
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
    Mandapati K; Gorla SK; House AL; McKenney ES; Zhang M; Rao SN; Gollapalli DR; Mann BJ; Goldberg JB; Cuny GD; Glomski IJ; Hedstrom L
    ACS Med Chem Lett; 2014 Aug; 5(8):846-50. PubMed ID: 25147601
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inosine 5'-Monophosphate Dehydrogenase (IMPDH) as a Potential Target for the Development of a New Generation of Antiprotozoan Agents.
    Fotie J
    Mini Rev Med Chem; 2018; 18(8):656-671. PubMed ID: 27334467
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.
    Macpherson IS; Kirubakaran S; Gorla SK; Riera TV; D'Aquino JA; Zhang M; Cuny GD; Hedstrom L
    J Am Chem Soc; 2010 Feb; 132(4):1230-1. PubMed ID: 20052976
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors.
    Lee S; Ku AF; Vippila MR; Wang Y; Zhang M; Wang X; Hedstrom L; Cuny GD
    Bioorg Med Chem Lett; 2020 Dec; 30(24):127543. PubMed ID: 32931912
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.
    Sarwono AEY; Mitsuhashi S; Kabir MHB; Shigetomi K; Okada T; Ohsaka F; Otsuguro S; Maenaka K; Igarashi M; Kato K; Ubukata M
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):171-178. PubMed ID: 30451014
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
    Trapero A; Pacitto A; Chan DS; Abell C; Blundell TL; Ascher DB; Coyne AG
    Bioorg Med Chem Lett; 2020 Jan; 30(2):126792. PubMed ID: 31757668
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
    Sintchak MD; Nimmesgern E
    Immunopharmacology; 2000 May; 47(2-3):163-84. PubMed ID: 10878288
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Prosise GL; Luecke H
    J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [The determination and clinical application of inosine 5’-monophosphate dehydrogenase activity].
    Liu FY; Qiu XY; Jiao Z
    Yao Xue Xue Bao; 2016 Nov; 51(11):1666-73. PubMed ID: 29908108
    [TBL] [Abstract][Full Text] [Related]  

  • 20. IMP dehydrogenase: the dynamics of drug selectivity.
    Hedstrom L; Gan L; Schlippe YG; Riera T; Seyedsayamdost M
    Nucleic Acids Res Suppl; 2003; (3):97-8. PubMed ID: 14510398
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.