BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

766 related articles for article (PubMed ID: 21518730)

  • 1. Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.
    Davranche A; Aviolat H; Zeder-Lutz G; Busso D; Altschuh D; Trottier Y; Klein FA
    Hum Mol Genet; 2011 Jul; 20(14):2795-806. PubMed ID: 21518730
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
    Zheng S; Ghitani N; Blackburn JS; Liu JP; Zeitlin SO
    Mol Brain; 2012 Aug; 5():28. PubMed ID: 22892315
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.
    Huang CC; Faber PW; Persichetti F; Mittal V; Vonsattel JP; MacDonald ME; Gusella JF
    Somat Cell Mol Genet; 1998 Jul; 24(4):217-33. PubMed ID: 10410676
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
    Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
    J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.
    Omi K; Hachiya NS; Tanaka M; Tokunaga K; Kaneko K
    Neurosci Lett; 2008 Jan; 431(1):45-50. PubMed ID: 18078716
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Computational investigation of molecular mechanism and neuropathological implications in Huntington disease.
    Gopalakrishnan C; Kalsi N; Jethi S; Purohit R
    Mol Cell Biochem; 2015 Nov; 409(1-2):1-11. PubMed ID: 26369532
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence for a recruitment and sequestration mechanism in Huntington's disease.
    Preisinger E; Jordan BM; Kazantsev A; Housman D
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun; 354(1386):1029-34. PubMed ID: 10434302
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
    Chongtham A; Bornemann DJ; Barbaro BA; Lukacsovich T; Agrawal N; Syed A; Worthge S; Purcell J; Burke J; Chin TM; Marsh JL
    Hum Mol Genet; 2020 Mar; 29(4):674-688. PubMed ID: 31943010
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration.
    Lu B; Palacino J
    FASEB J; 2013 May; 27(5):1820-9. PubMed ID: 23325320
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.
    Banerjee M; Datta M; Bhattacharyya NP
    Int J Biochem Cell Biol; 2017 Jan; 82():1-9. PubMed ID: 27840155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
    Poirier MA; Jiang H; Ross CA
    Hum Mol Genet; 2005 Mar; 14(6):765-74. PubMed ID: 15689354
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment.
    Persichetti F; Trettel F; Huang CC; Fraefel C; Timmers HT; Gusella JF; MacDonald ME
    Neurobiol Dis; 1999 Oct; 6(5):364-75. PubMed ID: 10527804
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.
    Dong X; Zong S; Witting A; Lindenberg KS; Kochanek S; Huang B
    J Gene Med; 2012 Jul; 14(7):468-81. PubMed ID: 22700462
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biophysical Aspect of Huntingtin Protein During polyQ: An In Silico Insight.
    Gopalakrishnan C; Jethi S; Kalsi N; Purohit R
    Cell Biochem Biophys; 2016 Jun; 74(2):129-39. PubMed ID: 27094178
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.
    Khoshnan A; Ko J; Patterson PH
    Proc Natl Acad Sci U S A; 2002 Jan; 99(2):1002-7. PubMed ID: 11792860
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aggregation in Huntington's disease: insights through modelling.
    Cajavec B; Bernard S; Herzel H
    Genome Inform; 2005; 16(1):262-71. PubMed ID: 16362929
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.
    Kegel KB; Schewkunow V; Sapp E; Masso N; Wanker EE; DiFiglia M; Goldmann WH
    Biochem Biophys Res Commun; 2009 Sep; 387(3):472-5. PubMed ID: 19607813
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of Aggregation of Mutant Huntingtin by Nucleic Acid Aptamers In Vitro and in a Yeast Model of Huntington's Disease.
    Chaudhary RK; Patel KA; Patel MK; Joshi RH; Roy I
    Mol Ther; 2015 Dec; 23(12):1912-26. PubMed ID: 26310631
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
    Legleiter J; Mitchell E; Lotz GP; Sapp E; Ng C; DiFiglia M; Thompson LM; Muchowski PJ
    J Biol Chem; 2010 May; 285(19):14777-90. PubMed ID: 20220138
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.
    Zheng S; Clabough EB; Sarkar S; Futter M; Rubinsztein DC; Zeitlin SO
    PLoS Genet; 2010 Feb; 6(2):e1000838. PubMed ID: 20140187
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 39.