These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

248 related articles for article (PubMed ID: 21522129)

  • 1. An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
    Petty TJ; Emamzadah S; Costantino L; Petkova I; Stavridi ES; Saven JG; Vauthey E; Halazonetis TD
    EMBO J; 2011 Jun; 30(11):2167-76. PubMed ID: 21522129
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reversal of the DNA-binding-induced loop L1 conformational switch in an engineered human p53 protein.
    Emamzadah S; Tropia L; Vincenti I; Falquet B; Halazonetis TD
    J Mol Biol; 2014 Feb; 426(4):936-44. PubMed ID: 24374182
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element.
    Emamzadah S; Tropia L; Halazonetis TD
    Mol Cancer Res; 2011 Nov; 9(11):1493-9. PubMed ID: 21933903
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.
    D'Abramo M; Bešker N; Desideri A; Levine AJ; Melino G; Chillemi G
    Oncogene; 2016 Jun; 35(25):3272-81. PubMed ID: 26477317
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutational analysis of the p53 core domain L1 loop.
    Zupnick A; Prives C
    J Biol Chem; 2006 Jul; 281(29):20464-73. PubMed ID: 16687402
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.
    Suad O; Rozenberg H; Brosh R; Diskin-Posner Y; Kessler N; Shimon LJ; Frolow F; Liran A; Rotter V; Shakked Z
    J Mol Biol; 2009 Jan; 385(1):249-65. PubMed ID: 18996393
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.
    Ethayathulla AS; Nguyen HT; Viadiu H
    J Biol Chem; 2013 Feb; 288(7):4744-54. PubMed ID: 23243311
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.
    Zhao K; Chai X; Johnston K; Clements A; Marmorstein R
    J Biol Chem; 2001 Apr; 276(15):12120-7. PubMed ID: 11152481
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
    Halazonetis TD; Kandil AN
    EMBO J; 1993 Dec; 12(13):5057-64. PubMed ID: 8262048
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
    Gorina S; Pavletich NP
    Science; 1996 Nov; 274(5289):1001-5. PubMed ID: 8875926
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Specific DNA binding by different classes of human p53 mutants.
    Rolley N; Butcher S; Milner J
    Oncogene; 1995 Aug; 11(4):763-70. PubMed ID: 7651740
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.
    Ouaray Z; ElSawy KM; Lane DP; Essex JW; Verma C
    Proteins; 2016 Oct; 84(10):1443-61. PubMed ID: 27317883
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intrinsically disordered domain of tumor suppressor p53 facilitates target search by ultrafast transfer between different DNA strands.
    Itoh Y; Murata A; Takahashi S; Kamagata K
    Nucleic Acids Res; 2018 Aug; 46(14):7261-7269. PubMed ID: 29986056
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Investigating DNA Binding and Conformational Variation in Temperature Sensitive p53 Cancer Mutants Using QM-MM Simulations.
    Koulgi S; Achalere A; Sonavane U; Joshi R
    PLoS One; 2015; 10(11):e0143065. PubMed ID: 26579714
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dimerization of the core domain of the p53 family: a computational study.
    Madhumalar A; Jun LH; Lane DP; Verma CS
    Cell Cycle; 2009 Jan; 8(1):137-48. PubMed ID: 19106606
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.
    Waterman JL; Shenk JL; Halazonetis TD
    EMBO J; 1995 Feb; 14(3):512-9. PubMed ID: 7859740
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group.
    Hansen S; Hupp TR; Lane DP
    J Biol Chem; 1996 Feb; 271(7):3917-24. PubMed ID: 8632013
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based rescue of common tumor-derived p53 mutants.
    Wieczorek AM; Waterman JL; Waterman MJ; Halazonetis TD
    Nat Med; 1996 Oct; 2(10):1143-6. PubMed ID: 8837616
    [TBL] [Abstract][Full Text] [Related]  

  • 19. iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
    Chen S; Wu J; Zhong S; Li Y; Zhang P; Ma J; Ren J; Tan Y; Wang Y; Au KF; Siebold C; Bond GL; Chen Z; Lu M; Jones EY; Lu X
    Proc Natl Acad Sci U S A; 2019 Aug; 116(35):17470-17479. PubMed ID: 31395738
    [TBL] [Abstract][Full Text] [Related]  

  • 20. P53 conformational switching for selectivity may reveal a general solution for specific DNA binding.
    Tubbs JL; Tainer JA
    EMBO J; 2011 Jun; 30(11):2099-100. PubMed ID: 21629273
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.