217 related articles for article (PubMed ID: 21531718)
1. Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.
Nelson O; Supnet C; Tolia A; Horré K; De Strooper B; Bezprozvanny I
J Biol Chem; 2011 Jun; 286(25):22339-47. PubMed ID: 21531718
[TBL] [Abstract][Full Text] [Related]
2. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
Nelson O; Tu H; Lei T; Bentahir M; de Strooper B; Bezprozvanny I
J Clin Invest; 2007 May; 117(5):1230-9. PubMed ID: 17431506
[TBL] [Abstract][Full Text] [Related]
3. Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.
Rivabene R; Visentin S; Piscopo P; De Nuccio C; Crestini A; Svetoni F; Rosa P; Confaloni A
Exp Biol Med (Maywood); 2014 Feb; 239(2):213-24. PubMed ID: 24363250
[TBL] [Abstract][Full Text] [Related]
4. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
Tu H; Nelson O; Bezprozvanny A; Wang Z; Lee SF; Hao YH; Serneels L; De Strooper B; Yu G; Bezprozvanny I
Cell; 2006 Sep; 126(5):981-93. PubMed ID: 16959576
[TBL] [Abstract][Full Text] [Related]
5. Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.
Das HK; Tchedre K; Mueller B
J Neurochem; 2012 Aug; 122(3):487-500. PubMed ID: 22607268
[TBL] [Abstract][Full Text] [Related]
6. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
7. Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
Ryazantseva M; Skobeleva K; Glushankova L; Kaznacheyeva E
J Neurochem; 2016 Mar; 136(5):1085-95. PubMed ID: 26678016
[TBL] [Abstract][Full Text] [Related]
8. Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
Tong BC; Lee CS; Cheng WH; Lai KO; Foskett JK; Cheung KH
Sci Signal; 2016 Sep; 9(444):ra89. PubMed ID: 27601731
[TBL] [Abstract][Full Text] [Related]
9. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
Gong P; Vetrivel KS; Nguyen PD; Meckler X; Cheng H; Kounnas MZ; Wagner SL; Parent AT; Thinakaran G
J Biol Chem; 2010 Dec; 285(49):38042-52. PubMed ID: 20921220
[TBL] [Abstract][Full Text] [Related]
10. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA; Xia W; Shen J; Kelleher RJ
J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
[TBL] [Abstract][Full Text] [Related]
11. Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2.
Mehra R; Kepp KP
J Phys Chem B; 2020 Jun; 124(23):4697-4711. PubMed ID: 32420742
[TBL] [Abstract][Full Text] [Related]
12. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
13. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.
Takagi S; Tominaga A; Sato C; Tomita T; Iwatsubo T
J Neurosci; 2010 Nov; 30(47):15943-50. PubMed ID: 21106832
[TBL] [Abstract][Full Text] [Related]
14. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; Sato T; Dolios G; Wang R; De Strooper B; Shoji M; Komano H; Yanagisawa K; Ihara Y; Fraser P; St George-Hyslop P; Nishimura M
J Biol Chem; 2005 May; 280(19):19070-7. PubMed ID: 15764596
[TBL] [Abstract][Full Text] [Related]
15. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
Sato C; Takagi S; Tomita T; Iwatsubo T
J Neurosci; 2008 Jun; 28(24):6264-71. PubMed ID: 18550769
[TBL] [Abstract][Full Text] [Related]
16. Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.
Cai T; Yonaga M; Tomita T
J Neurosci; 2017 Dec; 37(50):12272-12280. PubMed ID: 29118109
[TBL] [Abstract][Full Text] [Related]
17. Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.
Honarnejad K; Jung CK; Lammich S; Arzberger T; Kretzschmar H; Herms J
J Cell Mol Med; 2013 Feb; 17(2):293-302. PubMed ID: 23379308
[TBL] [Abstract][Full Text] [Related]
18. Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.
Nelson O; Supnet C; Liu H; Bezprozvanny I
J Alzheimers Dis; 2010; 21(3):781-93. PubMed ID: 20634584
[TBL] [Abstract][Full Text] [Related]
19. Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
Elzinga BM; Twomey C; Powell JC; Harte F; McCarthy JV
J Biol Chem; 2009 Jan; 284(3):1394-409. PubMed ID: 18996842
[TBL] [Abstract][Full Text] [Related]
20. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.
Takeo K; Watanabe N; Tomita T; Iwatsubo T
J Biol Chem; 2012 Jul; 287(31):25834-43. PubMed ID: 22689582
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]