163 related articles for article (PubMed ID: 2153214)
1. GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.
Nielsen L; Brehm L; Krogsgaard-Larsen P
J Med Chem; 1990 Jan; 33(1):71-7. PubMed ID: 2153214
[TBL] [Abstract][Full Text] [Related]
2. Effect of homo-beta-proline and other heterocyclic GABA analogues on GABA uptake in neurons and astroglial cells and on GABA receptor binding.
Larsson OM; Thorbek P; Krogsgaard-Larsen P; Schousboe A
J Neurochem; 1981 Dec; 37(6):1509-16. PubMed ID: 6278078
[TBL] [Abstract][Full Text] [Related]
3. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
Falch E; Hedegaard A; Nielsen L; Jensen BR; Hjeds H; Krogsgaard-Larsen P
J Neurochem; 1986 Sep; 47(3):898-903. PubMed ID: 3016189
[TBL] [Abstract][Full Text] [Related]
4. GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Falch E; Krogsgaard-Larsen P
Drug Des Deliv; 1989 May; 4(3):205-15. PubMed ID: 2535204
[TBL] [Abstract][Full Text] [Related]
5. GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Krogsgaard-Larsen P; Nielsen L; Falch E; Curtis DR
J Med Chem; 1985 Nov; 28(11):1612-7. PubMed ID: 2999396
[TBL] [Abstract][Full Text] [Related]
6. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Andersen KE; Braestrup C; Grønwald FC; Jørgensen AS; Nielsen EB; Sonnewald U; Sørensen PO; Suzdak PD; Knutsen LJ
J Med Chem; 1993 Jun; 36(12):1716-25. PubMed ID: 8510100
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Andersen KE; Sørensen JL; Huusfeldt PO; Knutsen LJ; Lau J; Lundt BF; Petersen H; Suzdak PD; Swedberg MD
J Med Chem; 1999 Oct; 42(21):4281-91. PubMed ID: 10543872
[TBL] [Abstract][Full Text] [Related]
8. Na(+)-dependent GABA transport system scavenges endogenous external GABA and prevents desensitization of GABAA receptors in rat cerebrocortical synaptoneurosomes.
Im WB; Blakeman DP; Davis JP
Brain Res; 1990 Jun; 521(1-2):143-7. PubMed ID: 2169957
[TBL] [Abstract][Full Text] [Related]
9. Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.
Falch E; Perregaard J; FrŁlund B; SŁkilde B; Buur A; Hansen LM; Frydenvang K; Brehm L; Bolvig T; Larsson OM; Sanchez C; White HS; Schousboe A; Krogsgaard-Larsen P
J Med Chem; 1999 Dec; 42(26):5402-14. PubMed ID: 10639282
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Andersen KE; Sørensen JL; Lau J; Lundt BF; Petersen H; Huusfeldt PO; Suzdak PD; Swedberg MD
J Med Chem; 2001 Jun; 44(13):2152-63. PubMed ID: 11405652
[TBL] [Abstract][Full Text] [Related]
11. GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
Krogsgaard-Larsen P; Frølund B; Frydenvang K
Curr Pharm Des; 2000 Aug; 6(12):1193-209. PubMed ID: 10903390
[TBL] [Abstract][Full Text] [Related]
12. Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Pavia MR; Lobbestael SJ; Nugiel D; Mayhugh DR; Gregor VE; Taylor CP; Schwarz RD; Brahce L; Vartanian MG
J Med Chem; 1992 Oct; 35(22):4238-48. PubMed ID: 1433224
[TBL] [Abstract][Full Text] [Related]
13. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier.
Braestrup C; Nielsen EB; Sonnewald U; Knutsen LJ; Andersen KE; Jansen JA; Frederiksen K; Andersen PH; Mortensen A; Suzdak PD
J Neurochem; 1990 Feb; 54(2):639-47. PubMed ID: 2299358
[TBL] [Abstract][Full Text] [Related]
14. Entropy as a factor in the binding of gamma-aminobutyric acid and nipecotic acid to the gamma-aminobutyric acid transport system.
Althaus JS; Martin DL
Neurochem Res; 1989 Apr; 14(4):311-6. PubMed ID: 2548104
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Knutsen LJ; Andersen KE; Lau J; Lundt BF; Henry RF; Morton HE; Naerum L; Petersen H; Stephensen H; Suzdak PD; Swedberg MD; Thomsen C; Sørensen PO
J Med Chem; 1999 Sep; 42(18):3447-62. PubMed ID: 10479278
[TBL] [Abstract][Full Text] [Related]
16. The spinal GABA system modulates burst frequency and intersegmental coordination in the lamprey: differential effects of GABAA and GABAB receptors.
Tegnér J; Matsushima T; el Manira A; Grillner S
J Neurophysiol; 1993 Mar; 69(3):647-57. PubMed ID: 8385187
[TBL] [Abstract][Full Text] [Related]
17. Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain.
Thomsen C; Suzdak PD
Epilepsy Res; 1995 Jun; 21(2):79-88. PubMed ID: 7588591
[TBL] [Abstract][Full Text] [Related]
18. Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.
Bonanno G; Raiteri M
Br J Pharmacol; 1987 May; 91(1):237-43. PubMed ID: 3594080
[TBL] [Abstract][Full Text] [Related]
19. [Nipecotic acid, a competitive inhibitor of the net uptake of 3H-GABA by rat brain synaptosomes].
Kovalev GI; Raevskiĭ KS
Biull Eksp Biol Med; 1981 Jun; 91(6):692-4. PubMed ID: 7272486
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of L-carnitine uptake into primary rat cortical cell cultures by GABA and GABA uptake blockers.
Virmani MA; Conti R; Spadoni A; Rossi S; Arrigoni-Martelli E
Pharmacol Res; 1995; 31(3-4):211-5. PubMed ID: 7630861
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
