BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

284 related articles for article (PubMed ID: 21543615)

  • 1. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
    Takasugi N; Sasaki T; Suzuki K; Osawa S; Isshiki H; Hori Y; Shimada N; Higo T; Yokoshima S; Fukuyama T; Lee VM; Trojanowski JQ; Tomita T; Iwatsubo T
    J Neurosci; 2011 May; 31(18):6850-7. PubMed ID: 21543615
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
    O'Connor T; Sadleir KR; Maus E; Velliquette RA; Zhao J; Cole SL; Eimer WA; Hitt B; Bembinster LA; Lammich S; Lichtenthaler SF; Hébert SS; De Strooper B; Haass C; Bennett DA; Vassar R
    Neuron; 2008 Dec; 60(6):988-1009. PubMed ID: 19109907
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    Ye X; Feng T; Tammineni P; Chang Q; Jeong YY; Margolis DJ; Cai H; Kusnecov A; Cai Q
    J Neurosci; 2017 Mar; 37(10):2639-2655. PubMed ID: 28159908
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
    Kurkinen KM; Marttinen M; Turner L; Natunen T; Mäkinen P; Haapalinna F; Sarajärvi T; Gabbouj S; Kurki M; Paananen J; Koivisto AM; Rauramaa T; Leinonen V; Tanila H; Soininen H; Lucas FR; Haapasalo A; Hiltunen M
    J Cell Sci; 2016 Jun; 129(11):2224-38. PubMed ID: 27084579
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
    Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
    J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
    [TBL] [Abstract][Full Text] [Related]  

  • 9. p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
    Saadipour K; Mañucat-Tan NB; Lim Y; Keating DJ; Smith KS; Zhong JH; Liao H; Bobrovskaya L; Wang YJ; Chao MV; Zhou XF
    J Neurochem; 2018 Feb; 144(3):302-317. PubMed ID: 28869759
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
    Andrew RJ; Fernandez CG; Stanley M; Jiang H; Nguyen P; Rice RC; Buggia-Prévot V; De Rossi P; Vetrivel KS; Lamb R; Argemi A; Allaert ES; Rathbun EM; Krause SV; Wagner SL; Parent AT; Holtzman DM; Thinakaran G
    Proc Natl Acad Sci U S A; 2017 Nov; 114(45):E9665-E9674. PubMed ID: 29078331
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.
    Devi L; Ohno M
    Mol Brain; 2015 Mar; 8():19. PubMed ID: 25884928
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
    Kim W; Ma L; Lomoio S; Willen R; Lombardo S; Dong J; Haydon PG; Tesco G
    Mol Neurodegener; 2018 Feb; 13(1):6. PubMed ID: 29391027
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer's Disease.
    Tan X; Luo Y; Pi D; Xia L; Li Z; Tu Q
    Curr Neurovasc Res; 2020; 17(1):86-92. PubMed ID: 31957613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells.
    Chen LM; Lin ZY; Zhu YG; Lin N; Zhang J; Pan XD; Chen XC
    Eur J Pharmacol; 2012 Jan; 675(1-3):15-21. PubMed ID: 22166376
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.
    Yi H; Lee SJ; Lee J; Myung CS; Park WK; Lim HJ; Lee GH; Kong JY; Cho H
    Neurochem Res; 2011 Nov; 36(11):2083-90. PubMed ID: 21674237
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer's Disease.
    Shah H; Patel A; Parikh V; Nagani A; Bhimani B; Shah U; Bambharoliya T
    CNS Neurol Disord Drug Targets; 2020; 19(3):184-194. PubMed ID: 32452328
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G; Sankaranarayanan S; Hsieh SH; Simon AJ; Savage MJ
    J Neurosci Res; 2011 Jun; 89(6):822-32. PubMed ID: 21433051
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
    Mao P; Manczak M; Calkins MJ; Truong Q; Reddy TP; Reddy AP; Shirendeb U; Lo HH; Rabinovitch PS; Reddy PH
    Hum Mol Genet; 2012 Jul; 21(13):2973-90. PubMed ID: 22492996
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells.
    Dai X; Chang P; Li X; Gao Z; Sun Y
    Neurosci Lett; 2018 Feb; 665():80-85. PubMed ID: 29175631
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.