122 related articles for article (PubMed ID: 21546253)
1. Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Kato A; Miyauchi S; Kato N; Nash RJ; Yoshimura Y; Nakagome I; Hirono S; Takahata H; Adachi I
Bioorg Med Chem; 2011 Jun; 19(11):3558-68. PubMed ID: 21546253
[TBL] [Abstract][Full Text] [Related]
2. Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.
Kato A; Nakagome I; Nakagawa S; Koike Y; Nash RJ; Adachi I; Hirono S
Bioorg Med Chem; 2014 Apr; 22(8):2435-41. PubMed ID: 24657053
[TBL] [Abstract][Full Text] [Related]
3. A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.
Lebl R; Thonhofer M; Tysoe C; Pabst BM; Schalli M; Weber P; Paschke E; Stütz AE; Tschernutter M; Windischhofer W; Withers SG
Carbohydr Res; 2017 Apr; 442():31-40. PubMed ID: 28288345
[TBL] [Abstract][Full Text] [Related]
4. (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.
Front S; Biela-Banaś A; Burda P; Ballhausen D; Higaki K; Caciotti A; Morrone A; Charollais-Thoenig J; Gallienne E; Demotz S; Martin OR
Eur J Med Chem; 2017 Jan; 126():160-170. PubMed ID: 27750150
[TBL] [Abstract][Full Text] [Related]
5. Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.
Baudoin-Dehoux C; Castellan T; Rodriguez F; Rives A; Stauffert F; Garcia V; Levade T; Compain P; Génisson Y
Molecules; 2019 Jan; 24(2):. PubMed ID: 30669468
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Thonhofer M; Weber P; Santana AG; Fischer R; Pabst BM; Paschke E; Schalli M; Stütz AE; Tschernutter M; Windischhofer W; Withers SG
Bioorg Med Chem Lett; 2016 Mar; 26(5):1438-42. PubMed ID: 26838810
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and evaluation of the glycosidase inhibitory activity of 5-hydroxy substituted isofagomine analogues.
Matin MM; Sharma T; Sabharwal SG; Dhavale DD
Org Biomol Chem; 2005 May; 3(9):1702-7. PubMed ID: 15858653
[TBL] [Abstract][Full Text] [Related]
8. 5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease.
Thonhofer M; Gonzalez Santana A; Fischer R; Torvisco Gomez A; Saf R; Schalli M; Stütz AE; Withers SG
Carbohydr Res; 2016 Feb; 420():6-12. PubMed ID: 26717544
[TBL] [Abstract][Full Text] [Related]
9. Imino- and Azasugar Protonation Inside Human Acid β-Glucosidase, the Enzyme that is Defective in Gaucher Disease.
Matassini C; Warren J; Wang B; Goti A; Cardona F; Morrone A; Bols M
Angew Chem Int Ed Engl; 2020 Jun; 59(26):10466-10469. PubMed ID: 32191378
[TBL] [Abstract][Full Text] [Related]
10. A potential fortuitous binding of inhibitors of an inverting family GH9 β-glycosidase derived from isofagomine.
Moréra S; Vigouroux A; Stubbs KA
Org Biomol Chem; 2011 Sep; 9(17):5945-7. PubMed ID: 21785782
[TBL] [Abstract][Full Text] [Related]
11. A fluorescence study of isofagomine protonation in β-glucosidase.
Lindbäck E; Laursen BW; Poulsen JC; Kilså K; Pedersen CM; Bols M
Org Biomol Chem; 2015 Jun; 13(23):6562-6. PubMed ID: 25978843
[TBL] [Abstract][Full Text] [Related]
12. Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and
Weber P; Thonhofer M; Averill S; Davies GJ; Santana AG; Müller P; Nasseri SA; Offen WA; Pabst BM; Paschke E; Schalli M; Torvisco A; Tschernutter M; Tysoe C; Windischhofer W; Withers SG; Wolfsgruber A; Wrodnigg TM; Stütz AE
Molecules; 2020 Sep; 25(17):. PubMed ID: 32899288
[TBL] [Abstract][Full Text] [Related]
13. Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
Asano N; Nishida M; Kato A; Kizu H; Matsui K; Shimada Y; Itoh T; Baba M; Watson AA; Nash RJ; Lilley PM; Watkin DJ; Fleet GW
J Med Chem; 1998 Jul; 41(14):2565-71. PubMed ID: 9651160
[TBL] [Abstract][Full Text] [Related]
14. N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase.
Sevšek A; Šrot L; Rihter J; Čelan M; van Ufford LQ; Moret EE; Martin NI; Pieters RJ
ChemMedChem; 2017 Apr; 12(7):483-486. PubMed ID: 28328014
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of β-glucocerebrosidase.
Hill T; Tropak MB; Mahuran D; Withers SG
Chembiochem; 2011 Sep; 12(14):2151-4. PubMed ID: 21751327
[No Abstract] [Full Text] [Related]
16. Rational design and synthesis of highly potent beta-glucocerebrosidase inhibitors.
Zhu X; Sheth KA; Li S; Chang HH; Fan JQ
Angew Chem Int Ed Engl; 2005 Dec; 44(45):7450-3. PubMed ID: 16231389
[No Abstract] [Full Text] [Related]
17. 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations.
Front S; Almeida S; Zoete V; Charollais-Thoenig J; Gallienne E; Marmy C; Pilloud V; Marti R; Wood T; Martin OR; Demotz S
Bioorg Med Chem; 2018 Nov; 26(20):5462-5469. PubMed ID: 30270003
[TBL] [Abstract][Full Text] [Related]
18. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Lieberman RL; Wustman BA; Huertas P; Powe AC; Pine CW; Khanna R; Schlossmacher MG; Ringe D; Petsko GA
Nat Chem Biol; 2007 Feb; 3(2):101-7. PubMed ID: 17187079
[TBL] [Abstract][Full Text] [Related]
19. Hydrophilic iminosugar active-site-specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients.
Chang HH; Asano N; Ishii S; Ichikawa Y; Fan JQ
FEBS J; 2006 Sep; 273(17):4082-92. PubMed ID: 16934036
[TBL] [Abstract][Full Text] [Related]
20. Isofagomine induced stabilization of glucocerebrosidase.
Kornhaber GJ; Tropak MB; Maegawa GH; Tuske SJ; Coales SJ; Mahuran DJ; Hamuro Y
Chembiochem; 2008 Nov; 9(16):2643-9. PubMed ID: 18932186
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]