BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 21550385)

  • 1. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species.
    Ye L; Wang T; Yang C; Tang L; Zhou J; Lv C; Gong Y; Jiang Z; Liu Z
    Toxicol Lett; 2011 Jul; 204(1):81-91. PubMed ID: 21550385
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine.
    Ye L; Tang L; Gong Y; Lv C; Zheng Z; Jiang Z; Liu Z
    Xenobiotica; 2011 Jan; 41(1):46-58. PubMed ID: 21105783
    [TBL] [Abstract][Full Text] [Related]  

  • 3. [Metabolites and metabolic pathways of mesaconitine in rat liver microsomal investigated by using UPLC-MS/MS method in vitro].
    Bi YF; Liu S; Zhang RX; Song FR; Liu ZQ
    Yao Xue Xue Bao; 2013 Dec; 48(12):1823-8. PubMed ID: 24689241
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes.
    Tang L; Ye L; Lv C; Zheng Z; Gong Y; Liu Z
    Toxicol Lett; 2011 Apr; 202(1):47-54. PubMed ID: 21277363
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine.
    Wang Y; Wang S; Liu Y; Yan L; Dou G; Gao Y
    J Chromatogr B Analyt Technol Biomed Life Sci; 2006 Dec; 844(2):292-300. PubMed ID: 16949890
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
    Wu WN; McKown LA; Reitz AB
    Eur J Drug Metab Pharmacokinet; 2006; 31(4):277-83. PubMed ID: 17315539
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
    Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
    Wang L; Zhang D; Raghavan N; Yao M; Ma L; Frost CE; Maxwell BD; Chen SY; He K; Goosen TC; Humphreys WG; Grossman SJ
    Drug Metab Dispos; 2010 Mar; 38(3):448-58. PubMed ID: 19940026
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes.
    Kong TY; Kim JH; Choi WG; Lee JY; Kim HS; Kim JY; In MK; Lee HS
    Anal Bioanal Chem; 2017 Feb; 409(6):1667-1680. PubMed ID: 27924364
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS(n) combined with specific inhibitors.
    Bi Y; Zhuang X; Zhu H; Song F; Liu Z; Liu S
    Biomed Chromatogr; 2015 Jul; 29(7):1027-34. PubMed ID: 25425064
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.
    Yan Z; Caldwell GW; Wu WN; McKown LA; Rafferty B; Jones W; Masucci JA
    Xenobiotica; 2002 Nov; 32(11):949-62. PubMed ID: 12487725
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
    Zhang Y; Guo X; Lin ET; Benet LZ
    Pharmacology; 1999 Mar; 58(3):147-59. PubMed ID: 9925971
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.
    Jiang R; Yamaori S; Takeda S; Yamamoto I; Watanabe K
    Life Sci; 2011 Aug; 89(5-6):165-70. PubMed ID: 21704641
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
    Xu L; Woodward C; Khan S; Prakash C
    Drug Metab Dispos; 2012 Apr; 40(4):680-93. PubMed ID: 22217465
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S; Fujimaki Y; Yokoyama H; Okazaki O; Sudo K
    Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
    Mahajan MK; Uttamsingh V; Daniels JS; Gan LS; LeDuc BW; Williams DA
    Drug Metab Dispos; 2011 Apr; 39(4):693-702. PubMed ID: 21177487
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.
    Zhao K; Ding M; Cao H; Cao ZX
    J Pharm Pharmacol; 2012 Oct; 64(10):1445-51. PubMed ID: 22943175
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.
    Butler AM; Murray M
    J Pharmacol Exp Ther; 1997 Feb; 280(2):966-73. PubMed ID: 9023313
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes.
    Kobayashi K; Chiba K; Yagi T; Shimada N; Taniguchi T; Horie T; Tani M; Yamamoto T; Ishizaki T; Kuroiwa Y
    J Pharmacol Exp Ther; 1997 Feb; 280(2):927-33. PubMed ID: 9023308
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.