158 related articles for article (PubMed ID: 21555506)
1. The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
Potega A; Dabrowska E; Niemira M; Kot-Wasik A; Ronseaux S; Henderson CJ; Wolf CR; Mazerska Z
Drug Metab Dispos; 2011 Aug; 39(8):1423-32. PubMed ID: 21555506
[TBL] [Abstract][Full Text] [Related]
2. Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
Fedejko-Kap B; Niemira M; Radominska-Pandya A; Mazerska Z
Xenobiotica; 2011 Dec; 41(12):1044-55. PubMed ID: 21859392
[TBL] [Abstract][Full Text] [Related]
3. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
Rawden HC; Kokwaro GO; Ward SA; Edwards G
Br J Clin Pharmacol; 2000 Apr; 49(4):313-22. PubMed ID: 10759686
[TBL] [Abstract][Full Text] [Related]
4. Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase.
Kousba A; Soll R; Yee S; Martin M
Drug Metab Dispos; 2007 Dec; 35(12):2242-51. PubMed ID: 17881660
[TBL] [Abstract][Full Text] [Related]
5. Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Fedejko-Kap B; Bratton SM; Finel M; Radominska-Pandya A; Mazerska Z
Drug Metab Dispos; 2012 Sep; 40(9):1736-43. PubMed ID: 22659092
[TBL] [Abstract][Full Text] [Related]
6. S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes.
Ohmi N; Yoshida H; Endo H; Hasegawa M; Akimoto M; Higuchi S
Xenobiotica; 2003 Dec; 33(12):1221-31. PubMed ID: 14742144
[TBL] [Abstract][Full Text] [Related]
7. In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms.
Lang DH; Rettie AE
Br J Clin Pharmacol; 2000 Oct; 50(4):311-4. PubMed ID: 11012553
[TBL] [Abstract][Full Text] [Related]
8. Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.
Taniguchi-Takizawa T; Shimizu M; Kume T; Yamazaki H
Drug Metab Pharmacokinet; 2015 Feb; 30(1):64-9. PubMed ID: 25760531
[TBL] [Abstract][Full Text] [Related]
9. Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor.
Kim YW; Kim YK; Kim DK; Sheen YY
Xenobiotica; 2008 May; 38(5):451-64. PubMed ID: 18421620
[TBL] [Abstract][Full Text] [Related]
10. Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.
Rooseboom M; Commandeur JN; Floor GC; Rettie AE; Vermeulen NP
Chem Res Toxicol; 2001 Jan; 14(1):127-34. PubMed ID: 11170516
[TBL] [Abstract][Full Text] [Related]
11. Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.
Blake BL; Rose RL; Mailman RB; Levi PE; Hodgson E
Xenobiotica; 1995 Apr; 25(4):377-93. PubMed ID: 7645304
[TBL] [Abstract][Full Text] [Related]
12. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.
Chung WG; Park CS; Roh HK; Lee WK; Cha YN
Jpn J Pharmacol; 2000 Oct; 84(2):213-20. PubMed ID: 11128045
[TBL] [Abstract][Full Text] [Related]
13. Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
Dalmadi B; Leibinger J; Szeberényi S; Borbás T; Farkas S; Szombathelyi Z; Tihanyi K
Drug Metab Dispos; 2003 May; 31(5):631-6. PubMed ID: 12695352
[TBL] [Abstract][Full Text] [Related]
14. A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes.
Grothusen A; Hardt J; Bräutigam L; Lang D; Böcker R
Arch Toxicol; 1996; 71(1-2):64-71. PubMed ID: 9010587
[TBL] [Abstract][Full Text] [Related]
15. Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate.
Madan A; Parkinson A; Faiman MD
Biochem Pharmacol; 1993 Dec; 46(12):2291-7. PubMed ID: 8274163
[TBL] [Abstract][Full Text] [Related]
16. Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver.
Wiśniewska A; Chrapkowska A; Kot-Wasik A; Konopa J; Mazerska Z
Acta Biochim Pol; 2007; 54(4):831-8. PubMed ID: 18084652
[TBL] [Abstract][Full Text] [Related]
17. Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli.
Rettie AE; Lawton MP; Sadeque AJ; Meier GP; Philpot RM
Arch Biochem Biophys; 1994 Jun; 311(2):369-77. PubMed ID: 8203899
[TBL] [Abstract][Full Text] [Related]
18. Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.
Shiraga T; Kaneko H; Iwasaki K; Tozuka Z; Suzuki A; Hata T
Xenobiotica; 1999 Mar; 29(3):217-29. PubMed ID: 10219963
[TBL] [Abstract][Full Text] [Related]
19. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members.
Stearns RA; Chakravarty PK; Chen R; Chiu SH
Drug Metab Dispos; 1995 Feb; 23(2):207-15. PubMed ID: 7736913
[TBL] [Abstract][Full Text] [Related]
20. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
Zhang WV; D'Esposito F; Edwards RJ; Ramzan I; Murray M
Drug Metab Dispos; 2008 Dec; 36(12):2547-55. PubMed ID: 18809730
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
