BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

230 related articles for article (PubMed ID: 21561857)

  • 1. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).
    Keshwani MM; von Daake S; Newton AC; Harris TK; Taylor SS
    J Biol Chem; 2011 Jul; 286(26):23552-8. PubMed ID: 21561857
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
    Collins BJ; Deak M; Murray-Tait V; Storey KG; Alessi DR
    J Cell Sci; 2005 Nov; 118(Pt 21):5023-34. PubMed ID: 16219676
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1).
    Ragan TJ; Ross DB; Keshwani MM; Harris TK
    Protein Expr Purif; 2008 Feb; 57(2):271-9. PubMed ID: 17980619
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of hydrophobic motif and activation loop phosphorylation is a consequence and not the mechanism of S6 kinase 1 inhibition by rapamycin.
    Beigh MA; Showkat M; Hussain MU; Andrabi KI
    J Biol Regul Homeost Agents; 2013; 27(2):399-408. PubMed ID: 23830390
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
    Frödin M; Antal TL; Dümmler BA; Jensen CJ; Deak M; Gammeltoft S; Biondi RM
    EMBO J; 2002 Oct; 21(20):5396-407. PubMed ID: 12374740
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.
    Wang J; Zhong C; Wang F; Qu F; Ding J
    Biochem J; 2013 Aug; 454(1):39-47. PubMed ID: 23731517
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
    Williams MR; Arthur JS; Balendran A; van der Kaay J; Poli V; Cohen P; Alessi DR
    Curr Biol; 2000 Apr; 10(8):439-48. PubMed ID: 10801415
    [TBL] [Abstract][Full Text] [Related]  

  • 8. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
    García-Martínez JM; Alessi DR
    Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.
    Romanelli A; Dreisbach VC; Blenis J
    J Biol Chem; 2002 Oct; 277(43):40281-9. PubMed ID: 12183455
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.
    Hong S; Zhao B; Lombard DB; Fingar DC; Inoki K
    J Biol Chem; 2014 May; 289(19):13132-41. PubMed ID: 24652283
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase.
    Rajan MR; Fagerholm S; Jönsson C; Kjølhede P; Turkina MV; Strålfors P
    PLoS One; 2013; 8(4):e59725. PubMed ID: 23565163
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
    Lizcano JM; Deak M; Morrice N; Kieloch A; Hastie CJ; Dong L; Schutkowski M; Reimer U; Alessi DR
    J Biol Chem; 2002 Aug; 277(31):27839-49. PubMed ID: 12023960
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation.
    Schalm SS; Tee AR; Blenis J
    J Biol Chem; 2005 Mar; 280(12):11101-6. PubMed ID: 15659381
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.
    Ali SM; Sabatini DM
    J Biol Chem; 2005 May; 280(20):19445-8. PubMed ID: 15809305
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
    Najafov A; Sommer EM; Axten JM; Deyoung MP; Alessi DR
    Biochem J; 2011 Jan; 433(2):357-69. PubMed ID: 21087210
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.
    Balendran A; Biondi RM; Cheung PC; Casamayor A; Deak M; Alessi DR
    J Biol Chem; 2000 Jul; 275(27):20806-13. PubMed ID: 10764742
    [TBL] [Abstract][Full Text] [Related]  

  • 17. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.
    Byfield MP; Murray JT; Backer JM
    J Biol Chem; 2005 Sep; 280(38):33076-82. PubMed ID: 16049009
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
    Alessi DR; Kozlowski MT; Weng QP; Morrice N; Avruch J
    Curr Biol; 1998 Jan; 8(2):69-81. PubMed ID: 9427642
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.
    Phin S; Kupferwasser D; Lam J; Lee-Fruman KK
    Biochem J; 2003 Jul; 373(Pt 2):583-91. PubMed ID: 12713446
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
    Nakashima A; Otsubo Y; Yamashita A; Sato T; Yamamoto M; Tamanoi F
    J Cell Sci; 2012 Dec; 125(Pt 23):5840-9. PubMed ID: 22976295
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.