These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

414 related articles for article (PubMed ID: 21569548)

  • 1. Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.
    Chen G; Zhang X; Zhao M; Wang Y; Cheng X; Wang D; Xu Y; Du Z; Yu X
    BMC Cancer; 2011 May; 11():170. PubMed ID: 21569548
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
    Jiang QW; Cheng KJ; Mei XL; Qiu JG; Zhang WJ; Xue YQ; Qin WM; Yang Y; Zheng DW; Chen Y; Wei MN; Zhang X; Lv M; Chen MW; Wei X; Shi Z
    Oncotarget; 2015 Oct; 6(32):32790-804. PubMed ID: 26447544
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
    Fan XX; Li N; Wu JL; Zhou YL; He JX; Liu L; Leung EL
    Molecules; 2014 Mar; 19(3):3508-22. PubMed ID: 24662070
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.
    Han X; Sun S; Zhao M; Cheng X; Chen G; Lin S; Guan Y; Yu X
    PLoS One; 2014; 9(11):e112470. PubMed ID: 25383959
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells.
    Liu X; Zhao P; Wang X; Wang L; Zhu Y; Song Y; Gao W
    J Exp Clin Cancer Res; 2019 May; 38(1):184. PubMed ID: 31053160
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells.
    Zhang T; Hamza A; Cao X; Wang B; Yu S; Zhan CG; Sun D
    Mol Cancer Ther; 2008 Jan; 7(1):162-70. PubMed ID: 18202019
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study.
    Li HY; Zhang J; Sun LL; Li BH; Gao HL; Xie T; Zhang N; Ye ZM
    Cell Death Dis; 2015 Jan; 6(1):e1604. PubMed ID: 25611379
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hexavalent chromium targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent caspase-3 activation in L-02 hepatocytes.
    Xiao F; Li Y; Dai L; Deng Y; Zou Y; Li P; Yang Y; Zhong C
    Int J Mol Med; 2012 Sep; 30(3):629-35. PubMed ID: 22710416
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling.
    Lee JH; Won YS; Park KH; Lee MK; Tachibana H; Yamada K; Seo KI
    Apoptosis; 2012 Dec; 17(12):1275-86. PubMed ID: 23065091
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.
    Boridy S; Le PU; Petrecca K; Maysinger D
    Cell Death Dis; 2014 May; 5(5):e1216. PubMed ID: 24810052
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS-mediated mitochondrial dysfunction.
    Guo Y; Zhang W; Yan YY; Ma CG; Wang X; Wang C; Zhao JL
    J BUON; 2013; 18(2):477-85. PubMed ID: 23818365
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Triterpene acids from Rosa roxburghii Tratt fruits exert anti-hepatocellular carcinoma activity via ROS/JNK signaling pathway-mediated cell cycle arrest and mitochondrial apoptosis.
    Zhai BW; Zhao H; Zhu HL; Huang H; Zhang MY; Fu YJ
    Phytomedicine; 2023 Oct; 119():154960. PubMed ID: 37531905
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway.
    Xu C; Wang X; Gu C; Zhang H; Zhang R; Dong X; Liu C; Hu X; Ji X; Huang S; Chen L
    J Neurochem; 2017 Apr; 141(1):48-62. PubMed ID: 28129433
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.
    Yu X; Zhou X; Fu C; Wang Q; Nie T; Zou F; Guo R; Liu H; Zhang B; Dai M
    Oncol Rep; 2015 Sep; 34(3):1129-36. PubMed ID: 26165547
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation.
    Liu X; Gao RW; Li M; Si CF; He YP; Wang M; Yang Y; Zheng QY; Wang CY
    Apoptosis; 2016 Nov; 21(11):1315-1326. PubMed ID: 27658784
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells.
    Kwak AW; Lee MJ; Lee MH; Yoon G; Cho SS; Chae JI; Shim JH
    Phytomedicine; 2021 Jun; 86():153564. PubMed ID: 33895649
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
    Raja SM; Clubb RJ; Ortega-Cava C; Williams SH; Bailey TA; Duan L; Zhao X; Reddi AL; Nyong AM; Natarajan A; Band V; Band H
    Cancer Biol Ther; 2011 Jan; 11(2):263-76. PubMed ID: 21088503
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.
    Jiang F; Wang HJ; Bao QC; Wang L; Jin YH; Zhang Q; Jiang D; You QD; Xu XL
    Bioorg Med Chem; 2016 Nov; 24(21):5431-5439. PubMed ID: 27647369
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS-Ca(2+)-JNK mitochondrial pathways.
    Zhang Y; Han L; Qi W; Cheng D; Ma X; Hou L; Cao X; Wang C
    Biochem Biophys Res Commun; 2015 Jan; 456(4):926-32. PubMed ID: 25529445
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.
    Yang XH; Zheng X; Cao JG; Xiang HL; Liu F; Lv Y
    World J Gastroenterol; 2010 Jul; 16(27):3385-93. PubMed ID: 20632440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.