BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 21576599)

  • 1. Cholesterol 25-hydroxylation activity of CYP3A.
    Honda A; Miyazaki T; Ikegami T; Iwamoto J; Maeda T; Hirayama T; Saito Y; Teramoto T; Matsuzaki Y
    J Lipid Res; 2011 Aug; 52(8):1509-16. PubMed ID: 21576599
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.
    Nitta SI; Hashimoto M; Kazuki Y; Takehara S; Suzuki H; Oshimura M; Akita H; Chiba K; Kobayashi K
    AAPS J; 2018 Apr; 20(3):61. PubMed ID: 29858698
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.
    Diczfalusy U; Björkhem I
    J Lipid Res; 2011 Aug; 52(8):1447-9. PubMed ID: 21652732
    [No Abstract]   [Full Text] [Related]  

  • 4. 7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase.
    Toll A; Wikvall K; Sudjana-Sugiaman E; Kondo KH; Björkhem I
    Eur J Biochem; 1994 Sep; 224(2):309-16. PubMed ID: 7925343
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol.
    Roumain M; Guillemot-Legris O; Ameraoui H; Alhouayek M; Muccioli GG
    J Steroid Biochem Mol Biol; 2023 Nov; 234():106376. PubMed ID: 37604319
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
    Morita K; Maeda Y; Masuda M; Kazusaka A; Imaoka S; Funae Y; Fujita S
    Biochem Pharmacol; 1998 May; 55(9):1405-11. PubMed ID: 10076532
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).
    Norlin M; Toll A; Björkhem I; Wikvall K
    J Lipid Res; 2000 Oct; 41(10):1629-39. PubMed ID: 11013305
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.
    Diczfalusy U; Miura J; Roh HK; Mirghani RA; Sayi J; Larsson H; Bodin KG; Allqvist A; Jande M; Kim JW; Aklillu E; Gustafsson LL; Bertilsson L
    Pharmacogenet Genomics; 2008 Mar; 18(3):201-8. PubMed ID: 18300941
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys.
    Li K; Zhao S; Zhang L; Wu X; Shu P; Wang Y; Feng H; Gu Z; Han Hsu H
    Drug Metab Dispos; 2014 May; 42(5):839-43. PubMed ID: 24595680
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes.
    Furster C; Wikvall K
    Biochim Biophys Acta; 1999 Jan; 1437(1):46-52. PubMed ID: 9931427
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.
    Honda A; Salen G; Matsuzaki Y; Batta AK; Xu G; Leitersdorf E; Tint GS; Erickson SK; Tanaka N; Shefer S
    J Biol Chem; 2001 Sep; 276(37):34579-85. PubMed ID: 11454857
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes.
    Martin KO; Budai K; Javitt NB
    J Lipid Res; 1993 Apr; 34(4):581-8. PubMed ID: 8496664
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.
    Björkhem I; Starck L; Andersson U; Lütjohann D; von Bahr S; Pikuleva I; Babiker A; Diczfalusy U
    J Lipid Res; 2001 Mar; 42(3):366-71. PubMed ID: 11254748
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.
    Bodin K; Bretillon L; Aden Y; Bertilsson L; Broomé U; Einarsson C; Diczfalusy U
    J Biol Chem; 2001 Oct; 276(42):38685-9. PubMed ID: 11514559
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians.
    Gebeyehu E; Engidawork E; Bijnsdorp A; Aminy A; Diczfalusy U; Aklillu E
    Pharmacogenomics J; 2011 Apr; 11(2):130-7. PubMed ID: 20231858
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.
    Josephson F; Bertilsson L; Böttiger Y; Flamholc L; Gisslén M; Ormaasen V; Sönnerborg A; Diczfalusy U
    Eur J Clin Pharmacol; 2008 Aug; 64(8):775-81. PubMed ID: 18458892
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).
    Norlin M; Andersson U; Björkhem I; Wikvall K
    J Biol Chem; 2000 Nov; 275(44):34046-53. PubMed ID: 10882719
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin.
    Yamazaki H; Shimada T
    Drug Metab Dispos; 1998 Nov; 26(11):1053-7. PubMed ID: 9806945
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.
    Wide K; Larsson H; Bertilsson L; Diczfalusy U
    Br J Clin Pharmacol; 2008 May; 65(5):708-15. PubMed ID: 18279471
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse.
    Meljon A; Wang Y; Griffiths WJ
    Biochem Biophys Res Commun; 2014 Apr; 446(3):768-74. PubMed ID: 24491562
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.