122 related articles for article (PubMed ID: 21589966)
1. Exo-cyclopamine--a stable and potent inhibitor of hedgehog-signaling.
Heretsch P; Büttner A; Tzagkaroulaki L; Zahn S; Kirchner B; Giannis A
Chem Commun (Camb); 2011 Jul; 47(26):7362-4. PubMed ID: 21589966
[TBL] [Abstract][Full Text] [Related]
2. Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.
Winkler JD; Isaacs A; Holderbaum L; Tatard V; Dahmane N
Org Lett; 2009 Jul; 11(13):2824-7. PubMed ID: 19552464
[TBL] [Abstract][Full Text] [Related]
3. Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
Tremblay MR; Nevalainen M; Nair SJ; Porter JR; Castro AC; Behnke ML; Yu LC; Hagel M; White K; Faia K; Grenier L; Campbell MJ; Cushing J; Woodward CN; Hoyt J; Foley MA; Read MA; Sydor JR; Tong JK; Palombella VJ; McGovern K; Adams J
J Med Chem; 2008 Nov; 51(21):6646-9. PubMed ID: 18842035
[TBL] [Abstract][Full Text] [Related]
4. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR; Lescarbeau A; Grogan MJ; Tan E; Lin G; Austad BC; Yu LC; Behnke ML; Nair SJ; Hagel M; White K; Conley J; Manna JD; Alvarez-Diez TM; Hoyt J; Woodward CN; Sydor JR; Pink M; MacDougall J; Campbell MJ; Cushing J; Ferguson J; Curtis MS; McGovern K; Read MA; Palombella VJ; Adams J; Castro AC
J Med Chem; 2009 Jul; 52(14):4400-18. PubMed ID: 19522463
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of cyclopamine using a biomimetic and diastereoselective approach.
Giannis A; Heretsch P; Sarli V; Stössel A
Angew Chem Int Ed Engl; 2009; 48(42):7911-4. PubMed ID: 19591183
[No Abstract] [Full Text] [Related]
6. Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives.
Heretsch P; Tzagkaroulaki L; Giannis A
Angew Chem Int Ed Engl; 2010 May; 49(20):3418-27. PubMed ID: 20429080
[TBL] [Abstract][Full Text] [Related]
7. Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine.
Zhang Z; Baubet V; Ventocilla C; Xiang C; Dahmane N; Winkler JD
Org Lett; 2011 Sep; 13(18):4786-9. PubMed ID: 21842835
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and anticancer activity studies of cyclopamine derivatives.
Zhang J; Garrossian M; Gardner D; Garrossian A; Chang YT; Kim YK; Chang CW
Bioorg Med Chem Lett; 2008 Feb; 18(4):1359-63. PubMed ID: 18221872
[TBL] [Abstract][Full Text] [Related]
9. Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified.
Wilson SR; Strand MF; Krapp A; Rise F; Petersen D; Krauss S
J Pharm Biomed Anal; 2010 Sep; 52(5):707-13. PubMed ID: 20236786
[TBL] [Abstract][Full Text] [Related]
10. One Hundred Faces of Cyclopamine.
Iovine V; Mori M; Calcaterra A; Berardozzi S; Botta B
Curr Pharm Des; 2016; 22(12):1658-81. PubMed ID: 26759083
[TBL] [Abstract][Full Text] [Related]
11. Modulators of the hedgehog signaling pathway.
Heretsch P; Tzagkaroulaki L; Giannis A
Bioorg Med Chem; 2010 Sep; 18(18):6613-24. PubMed ID: 20708941
[TBL] [Abstract][Full Text] [Related]
12. Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro.
Chen XL; Cheng QY; She MR; Wang Q; Huang XH; Cao LQ; Fu XH; Chen JS
Arch Med Res; 2010 Jul; 41(5):315-23. PubMed ID: 20851287
[TBL] [Abstract][Full Text] [Related]
13. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.
Incardona JP; Gaffield W; Lange Y; Cooney A; Pentchev PG; Liu S; Watson JA; Kapur RP; Roelink H
Dev Biol; 2000 Aug; 224(2):440-52. PubMed ID: 10926779
[TBL] [Abstract][Full Text] [Related]
14. Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album.
Wilson SR; Strand MF; Krapp A; Rise F; Herstad G; Malterud KE; Krauss S
J Pharm Biomed Anal; 2010 Nov; 53(3):497-502. PubMed ID: 20646889
[TBL] [Abstract][Full Text] [Related]
15. Biology-driven diversity: concept of focused diversity.
Kiselyov AS
Chem Biol Drug Des; 2006 Jul; 68(1):67-9. PubMed ID: 16923028
[No Abstract] [Full Text] [Related]
16. Cyclopamine bioactivity by extraction method from Veratrum californicum.
Turner MW; Cruz R; Mattos J; Baughman N; Elwell J; Fothergill J; Nielsen A; Brookhouse J; Bartlett A; Malek P; Pu X; King MD; McDougal OM
Bioorg Med Chem; 2016 Aug; 24(16):3752-7. PubMed ID: 27338657
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
Guerlet G; Spangenberg T; Mann A; Faure H; Ruat M
Bioorg Med Chem Lett; 2011 Jun; 21(12):3608-12. PubMed ID: 21592788
[TBL] [Abstract][Full Text] [Related]
18. Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.
McCarthy FR; Brown AJ
Biochem Biophys Res Commun; 2008 Aug; 373(1):109-12. PubMed ID: 18544338
[TBL] [Abstract][Full Text] [Related]
19. Role of hedgehog signaling in ovarian cancer.
Bhattacharya R; Kwon J; Ali B; Wang E; Patra S; Shridhar V; Mukherjee P
Clin Cancer Res; 2008 Dec; 14(23):7659-66. PubMed ID: 19047091
[TBL] [Abstract][Full Text] [Related]
20. Cyclopamine: from cyclops lambs to cancer treatment.
Lee ST; Welch KD; Panter KE; Gardner DR; Garrossian M; Chang CW
J Agric Food Chem; 2014 Jul; 62(30):7355-62. PubMed ID: 24754790
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
